2012年10月
Reproductive factors and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women
Cancer Science
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- 巻
- 103
- 号
- 10
- 開始ページ
- 1861
- 終了ページ
- 1870
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1349-7006.2012.02379.x
- 出版者・発行元
- WILEY
The associations between menstrual and reproductive factors and breast cancer risk in relation to estrogen/progesterone receptor (ER/PgR) status have been unclear in Japanese women. This case-control study evaluated these associations, overall and separately, by menopausal status. A total of 1092 breast cancer cases and 3160 controls were selected from among female patients aged 30 years and over admitted to a single hospital in Miyagi Prefecture between 1997 and 2009. The receptor status distribution among the cases (missing: 8.4%) was 571 ER+/PgR+, 133 ER+/PgR-, 24 ER-/PgR+ and 271 ER-/PgR- Menstrual and reproductive factors were assessed using a self-administered questionnaire. Polytomous logistic regression and tests for heterogeneity across ER+/PgR+ and ER-/PgR- were conducted. Later age at menarche was significantly associated with a decreased risk of both ER+/PgR+ and ER-/PgR- cancer among women overall (P = 0.0016 for ER+/PgR+; P = 0.015 for ER-/PgR-) and among postmenopausal women (P = 0.012 for ER+/PgR+; P = 0.0056 for ER-/PgR-). Nulliparity was associated with an increased risk of ER+/PgR+, but not ER-/PgR- cancer among women overall (P = 0.019) and among postmenopausal women (odds ratio for ER+/PgR+ = 2.56, 95% confidence interval = 1.61-4.07; P = 0.0095). A longer duration of breastfeeding tended to be associated with a decreased risk in all subtypes among women overall. Later age at menarche has a protective effect against both ER+/PgR+ and ER-/PgR- cancer. However, parity might impact differently on various subtypes of breast cancer. Further studies are needed to clarify the etiology of the rare ER+/PgR- and ER-/PgR+ cancer subtypes. © 2012 Japanese Cancer Association. trend trend trend trend heterogeneity heterogeneity
- リンク情報
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- DOI
- https://doi.org/10.1111/j.1349-7006.2012.02379.x
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201502803445414225
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22762156
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659174
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000309600400017&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867233342&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84867233342&origin=inward
- URL
- http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2012.02379.x/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+7+July+from+10%3A00-12%3A00+BST+%2805%3A00-07%3A00+EDT%29+for+essential+maintenance
- ID情報
-
- DOI : 10.1111/j.1349-7006.2012.02379.x
- ISSN : 1347-9032
- eISSN : 1349-7006
- J-Global ID : 201502803445414225
- PubMed ID : 22762156
- PubMed Central 記事ID : PMC7659174
- SCOPUS ID : 84867233342
- Web of Science ID : WOS:000309600400017