論文

査読有り 国際誌
2021年3月30日

Antibacterial Chitosan Nanofiber Thin Films with Bacitracin Zinc Salt.

Polymers
  • Kazutaka Kumamoto
  • ,
  • Toshinari Maeda
  • ,
  • Satoshi Hayakawa
  • ,
  • Nurul Asyifah Binti Mustapha
  • ,
  • Meng-Jiy Wang
  • ,
  • Yuki Shirosaki

13
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/polym13071104

Chitosan nanofiber has a highly uniform structure of 20-50 nm in diameter and shows high dispersibility in water due to its submicron size and high surface-to-volume ratio. The stacked nanofibers film is useful for breathability because it has a gap with a size of several tens of nm or more. However, the chemical bonds between the nanofibers cannot be broken during use. In this study, the thin films were obtained by filtration of chitosan nanofibers and 3-glycidoxypropyltrimethoxysilane (GPTMS) mixture. The addition of GPTMS changed the wettability, mechanical property and stability in water of the thin films. Bacitracin zinc salt (BZ) has been used for the localized dermatological medicines and loaded in the films. BZ interacted electrostatically with the thin films matrix and the release of BZ was controlled by the amount of GPTMS. A higher released amount of BZ showed higher antibacterial effects toward S. aureus. The film was also tested their toxicity by L929 fibroblasts. The release of less than 11.9 μg of BZ showed antibacterial effects, but were not toxic for fibroblast cells.

リンク情報
DOI
https://doi.org/10.3390/polym13071104
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33808445
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036362
ID情報
  • DOI : 10.3390/polym13071104
  • PubMed ID : 33808445
  • PubMed Central 記事ID : PMC8036362

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