論文

査読有り 国際誌
2018年3月14日

Prognostic impacts of Rho-kinase activity in circulating leucocytes in patients with vasospastic angina.

European heart journal
  • Taro Nihei
  • ,
  • Jun Takahashi
  • ,
  • Kiyotaka Hao
  • ,
  • Yoku Kikuchi
  • ,
  • Yuji Odaka
  • ,
  • Ryuji Tsuburaya
  • ,
  • Kensuke Nishimiya
  • ,
  • Yasuharu Matsumoto
  • ,
  • Kenta Ito
  • ,
  • Satoshi Miyata
  • ,
  • Yasuhiko Sakata
  • ,
  • Hiroaki Shimokawa

39
11
開始ページ
952
終了ページ
959
記述言語
英語
掲載種別
DOI
10.1093/eurheartj/ehx657

Aims: Rho-kinase activity in circulating leucocytes is a useful biomarker for diagnosis and disease activity assessment of vasospastic angina (VSA). The present study aimed to examine the long-term prognostic impact of Rho-kinase activity in circulating leucocytes in VSA patients. Methods and results: We prospectively enrolled 174 consecutive patients with VSA and 50 non-VSA patients, in whom we measured Rho-kinase activity in circulating leucocytes, and they were followed for a median of 16 months. The primary endpoint was cardiac events including cardiac death, non-fatal myocardial infarction, and hospitalization for unstable angina. During the follow-up period, cardiac events occurred in 10 VSA patients (5.7%) but in none of the non-VSA patients. When we divided VSA patients into two groups by a median value of their Rho-kinase activity, the Kaplan-Meier survival analysis showed a significantly worse prognosis in VSA patients with high Rho-kinase activity compared with those with low activity or non-VSA patients (log-rank; P < 0.05, respectively). Receiver-operating characteristic curve analysis showed that Rho-kinase activity value of 1.24 was the best cut-off level to predict cardiac events in VSA patients, and multivariable analysis showed that a value above the cut-off point had the largest hazard ratio to predict poor outcome in VSA patients [hazard ratio (95% confidence interval) 11.19 (1.41-88.95); P = 0.022]. Importantly, combination of the Japanese Coronary Spasm Association risk score and Rho-kinase activity significantly improved the prognostic impact in VSA patients as compared with either alone. Conclusion: Rho-kinase activity in circulating leucocytes is useful for prognostic stratification of VSA patients.

リンク情報
DOI
https://doi.org/10.1093/eurheartj/ehx657
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29165549
ID情報
  • DOI : 10.1093/eurheartj/ehx657
  • ISSN : 0195-668X
  • PubMed ID : 29165549

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