2012年4月
Effect of Prenatal Valproic Acid Exposure on Cortical Morphology in Female Mice
JOURNAL OF PHARMACOLOGICAL SCIENCES
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- 巻
- 118
- 号
- 4
- 開始ページ
- 543
- 終了ページ
- 546
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1254/jphs.12025SC
- 出版者・発行元
- JAPANESE PHARMACOLOGICAL SOC
We have recently shown that prenatal valproic acid (VPA) exposure causes autism spectrum disorders-like behavioral abnormalities and Nissl-positive cell loss in both prefrontal and somatosensory cortices in male mice. We have also found that VPA-induced social interaction deficits are observed in male but not female offspring. This study demonstrated that the exposure to VPA at embryonic day 12.5 significantly decreased Nissl-positive cell numbers in the prefrontal cortex, but not in the somatosensory cortex, in female offspring. These findings suggest that VPA-induced morphological abnormalities in the somatosensory cortex may be involved in the sex-dependent social interaction deficits.
- リンク情報
- ID情報
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- DOI : 10.1254/jphs.12025SC
- ISSN : 1347-8613
- PubMed ID : 22447305
- Web of Science ID : WOS:000303298900017