論文

国際誌
2020年12月15日

Baroreflex Sensitivity in Patients With Atrial Fibrillation.

Journal of the American Heart Association
  • Miho Miyoshi
  • ,
  • Hidekazu Kondo
  • ,
  • Yumi Ishii
  • ,
  • Tetsuji Shinohara
  • ,
  • Keisuke Yonezu
  • ,
  • Taisuke Harada
  • ,
  • Hiroki Sato
  • ,
  • Yudai Yano
  • ,
  • Seiichiro Yoshimura
  • ,
  • Ichitaro Abe
  • ,
  • Takashi Shuto
  • ,
  • Hidefumi Akioka
  • ,
  • Yasushi Teshima
  • ,
  • Tomoyuki Wada
  • ,
  • Kunio Yufu
  • ,
  • Mikiko Nakagawa
  • ,
  • Hirofumi Anai
  • ,
  • Shinji Miyamoto
  • ,
  • Naohiko Takahashi

9
24
開始ページ
e018019
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1161/JAHA.120.018019

Background It has been reported that atrial fibrillation (AF) may contribute to impairment of baroreflex sensitivity (BRS). However, the difference of BRS between patients with persistent AF (PeAF) and those with paroxysmal AF (PAF) is unknown. We tested the hypothesis that patients with PeAF have a more impaired BRS compared with those with PAF. Methods and Results From October 2015 onwards, a total of 67 patients (14 women [20.9%]; mean age 65.2±10.1 years) with PAF (n=46, 68.7%) and PeAF (n=21, 31.3%), who underwent catheter ablation, were prospectively enrolled. The baseline BRS was evaluated during sinus rhythm. The baseline BRS in patients with PeAF was significantly lower than those with PAF (2.97 [0.52-6.62] ms/mm Hg versus 4.70 [2.36-8.37] ms/mm Hg, P=0.047). The BRS was significantly depressed after catheter ablation in all the patients (4.66 [1.80-7.37] ms/mm Hg versus 0.55 [-0.15 to 1.22] ms/mm Hg, P<0.001). However, the depression of BRS because of catheter ablation appeared attenuated in patients with PeAF when compared with those with PAF. The number of patients who did not show depression of BRS was significantly greater, that is, patients with PeAF (3/12, 25%) than those with PAF (0/46, 0%, P<0.01). Conclusions Our findings demonstrated that the baseline BRS was more depressed in patients with PeAF compared with PAF. Catheter ablation depressed BRS irrespective of the type of AF, with a greater effect in patients with PAF than PeAF.

リンク情報
DOI
https://doi.org/10.1161/JAHA.120.018019
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33263265
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955376
ID情報
  • DOI : 10.1161/JAHA.120.018019
  • PubMed ID : 33263265
  • PubMed Central 記事ID : PMC7955376

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