MASAYUKI HARAMURA

Profile Information

Affiliation: 教授, 理学部, 岡山理科大学

Researcher number: 90876939
J-GLOBAL ID: 202001000525067935
researchmap Member ID: R000011792

Research Interests

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development / Chemical Biology
Life sciences / Pharmaceuticals - chemistry and drug development / Peptide Chemistry
Life sciences / Pharmaceuticals - chemistry and drug development / Medicinal Chemistry

Research History

Apr, 2020 - Present

Faculty of Science, Okayama University of Science
Jan, 2016 - Mar, 2020

メディカルマネージャー, メディカルサイエンス部, 中外製薬株式会社
Jan, 2015 - Dec, 2015

グループマネージャー, 事業開発部, 中外製薬株式会社
Apr, 2006 - Dec, 2014

グループマネージャー, 鎌倉研究所, 中外製薬株式会社
Apr, 2011 - Mar, 2013

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Apr, 2010 - Mar, 2011

School of Bioscience and Biotechnology, Tokyo Institute of Technology
Mar, 2002 - Mar, 2006

リーダー研究員, 化学部門, 株式会社リバース・プロテオミクス研究所
Jan, 2000 - Feb, 2002

Scientist, Chemistry Department, Chugai Biopharmaceutical Inc.
Apr, 1988 - Dec, 1999

研究員, 富士御殿場研究所, 中外製薬株式会社

Education

Apr, 1986 - Mar, 1988

Graduate School of Science and Engineering, Waseda University
Apr, 1982 - Mar, 1986

School of Science and Engineering, Waseda University

Committee Memberships

Nov, 2013 - Dec, 2014

産学協力研究委員会「ゲノムテクノロジー第164委員会」, 独立行政法人日本学術振興会

Awards

Jul, 2012

研究開発功労賞（団体受賞代表）, 薬剤の作用機序解析および新規標的探索のためのプロテオミクス解析, 日本プロテオーム学会

中外製薬株式会社, プロテオミクス研究チーム

Papers

Patient-reported burden of symptoms in neuromyelitis optica: A secondary analysis on pain and quality of life.

Kazuo Fujihara, Satoshi Hattori, Ingo Kleiter, Michael Levy, Yuya Matsuda, Asako Mitsutake, Masayuki Haramura, Jacqueline Palace, Takashi Yamamura

Journal of the neurological sciences, 428 117546-117546, Jun 19, 2021
Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology

Kazuo Fujihara, Jeffrey L. Bennett, Jerome de Seze, Masayuki Haramura, Ingo Kleiter, Brian G. Weinshenker, Delene Kang, Tabasum Mughal, Takashi Yamamura

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 7(5), Sep, 2020 Peer-reviewed
Neuromyelitis optica spectrum disorder Patient experience and quality of life

Janine Beekman, Aysha Keisler, Omar Pedraza, Masayuki Haramura, Athos Gianella-Borradori, Eliezer Katz, John N. Ratchford, Gerard Barron, Lawrence J. Cook, Jacinta M. Behne, Terrence F. Blaschke, Terry J. Smith, Michael R. Yeaman

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 6(4) e580, Jul, 2019 Peer-reviewed
Identification and purification of target protein using affinity resin bearing a photo-labile linker

Miyuki Mabuchi, Tadashi Shimizu, Masayuki Haramura, Akito Tanaka

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16) 3373-3377, Aug, 2015 Peer-reviewed
Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing

Kohji Nagano, Takashi Shinkawa, Kuniyasu Kato, Noriyuki Inomata, Nami Yabuki, Masayuki Haramura

JOURNAL OF PROTEOMICS, 74(10) 1985-1993, Sep, 2011 Peer-reviewed
Integration of proteomic analyses to monitor the activity status of phosphorylation signaling

Kohji Nagano, Takashi Shinkawa, Nami Yabuki, Hironori Mutoh, Noriyuki Inomata, Yoshinori Watanabe, Motooki Ashihara, Shigehisa Nagahashi, Nobuya Ishii, Yuko Aoki, Masayuki Haramura

JOURNAL OF PROTEOMICS, 74(3) 319-326, Mar, 2011 Peer-reviewed
Selective elution of target protein from affinity resins by a simple reductant with a thiol group

Miyuki Mabuchi, Masayuki Haramura, Tadashi Shimizu, Tomoyuki Nishizaki, Akito Tanaka

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(24) 7361-7364, Dec, 2010 Peer-reviewed
Design and Synthesis of Peptidomimetic Factor VIIa Inhibitors

Takuya Shiraishi, Shojiro Kadono, Masayuki Haramura, Hirofumi Kodama, Yoshiyuki Ono, Hitoshi Iikura, Tohru Esaki, Takaki Koga, Kunihiro Hattori, Yoshiaki Watanabe, Akihisa Sakamoto, Kazutaka Yoshihashi, Takehisa Kitazawa, Keiko Esaki, Masateru Ohta, Haruhiko Sato, Toshiro Kozono

CHEMICAL & PHARMACEUTICAL BULLETIN, 58(1) 38-44, Jan, 2010 Peer-reviewed
A software program for more reliable precursor ion assignation from LC-MS analysis using LTQ ultra zoom scan

Takashi Shinkawa, Kohji Nagano, Noriyuki Inomata, Masayuki Haramura

JOURNAL OF PROTEOMICS, 73(2) 357-360, Dec, 2009 Peer-reviewed
Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment

Kohji Nagano, Takashi Shinkawa, Hironori Mutoh, Osamu Kondoh, Sayuri Morimoto, Noriyuki Inomata, Motooki Ashihara, Nobuya Ishii, Yuko Aoki, Masayuki Haramura

PROTEOMICS, 9(10) 2861-2874, May, 2009 Peer-reviewed
Structure-Based Drug Design of Peptide Mimetics Containing Large P3 Moieties as Inhibitors of Factor VIIa

Takuya Shiraishi, Shojiro Kadono, Masayuki Haramura, Hirofumi Kodama, Yoshiyuki Ono, Hitoshi Iikura, Tohru Esaki, Takaki Koga, Kunihiro Hattori, Yoshiaki Watanabe, Akihisa Sakamoto, Kazutaka Yoshihashi, Takehisa Kitazawa, Keiko Esaki, Masateru Ohta, Haruhiko Sato, Toshiro Kozono

LETTERS IN DRUG DESIGN & DISCOVERY, 6(2) 86-92, Mar, 2009 Peer-reviewed
Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination

Takuya Shiraishi, Shojiro Kadono, Masayuki Haramura, Hirofumi Kodama, Yoshiyuki Ono, Hitoshi Iikura, Tohru Esaki, Takaki Koga, Kunihiro Hattori, Yoshiaki Watanabe, Akihisa Sakamoto, Kazutaka Yoshihashi, Takehisa Kitazawa, Keiko Esaki, Masateru Ohta, Haruhiko Sato, Toshiro Kozono

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(16) 4533-4537, Aug, 2008 Peer-reviewed
Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors

David M. Wallace, Masayuki Haramura, Jie-Fei Cheng, Thomas Arrhenius, Alex M. Nadzan

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17(4) 1127-1130, Feb, 2007 Peer-reviewed
Application of chemical biology to proteomics in drug target discovery

Haramura Masayuki

Folia Pharmacologica Japonica, 129(2) 124-128, 2007
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors

Jie Fei Cheng, Mi Chen, David Wallace, Souvothy Tith, Masayuki Haramura, Bin Liu, Chi Ching Mak, Thomas Arrhenius, Sean Reily, Steven Brown, Vicki Thorn, Charles Harmon, Rick Barr, Jason R.B. Dyck, Gary D. Lopaschuk, Alex M. Nadzan

Journal of Medicinal Chemistry, 49(5) 1517-1525, Mar 5, 2006 Peer-reviewed
Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface

Minoru Furuya, Masayuki Haramura, Akito Tanaka

Bioorganic and Medicinal Chemistry, 14(2) 537-543, Jan 15, 2006 Peer-reviewed
Peptide mimetic factor VIIa inhibitor: Importance of hydrophilic pocket in S2 site to improve selectivity against thrombin

S. Kadono, A. Sakamoto, Y. Kikuchi, M. Oh-Eda, N. Yabuta, T. Koga, K. Hattori, T. Shiraishi, M. Haramura, H. Kodama, T. Esaki, H. Sato, Y. Watanabe, S. Itoh, M. Ohta, T. Kozono

Letters in Drug Design and Discovery, 2(3) 177-181, May, 2005 Peer-reviewed
Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor

Shojiro Kadono, Akihisa Sakamoto, Yasufumi Kikuchi, Masayoshi Oh-eda, Naohiro Yabuta, Kazutaka Yoshihashi, Takehisa Kitazawa, Tsukasa Suzuki, Takaki Koga, Kunihiro Hattori, Takuya Shiraishi, Masayuki Haramura, Hirofumi Kodama, Yoshiyuki Ono, Toru Esaki, Haruhiko Sato, Yoshiaki Watanabe, Susumu Itoh, Masateru Ohta, Toshiro Kozono

Biochemical and Biophysical Research Communications, 327(2) 589-596, Feb 11, 2005 Peer-reviewed
Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor

Shojiro Kadono, Akihisa Sakamoto, Yasufumi Kikuchi, Masayoshi Oh-Eda, Naohiro Yabuta, Kazutaka Yoshihashi, Takehisa Kitazawa, Tsukasa Suzuki, Takaki Koga, Kunihiro Hattori, Takuya Shiraishi, Masayuki Haramura, Hirofumi Kodama, Yoshiyuki Ono, Toru Esaki, Haruhiko Sato, Yoshiaki Watanabe, Susumu Itoh, Masateru Ohta, Toshiro Kozono

Biochemical and Biophysical Research Communications, 326(4) 859-865, Jan 28, 2005 Peer-reviewed
Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: High selectivity against thrombin by introducing two charged groups in P2 and P4

Shojiro Kadono, Akihisa Sakamoto, Yasufumi Kikuchi, Masayoshi Oh-Eda, Naohiro Yabuta, Takaki Koga, Kunihiro Hattori, Takuya Shiraishi, Masayuki Haramura, Hirofumi Kodama, Yoshiyuki Ono, Toru Esaki, Haruhiko Sato, Yoshiaki Watanabe, Susumu Itoh, Masateru Ohta, Toshiro Kozono

Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 61(2) 169-173, 2005 Peer-reviewed

Misc.

Efficacy of Satralizumab (SA237) in Subgroups of Patients in SakuraSky: A Phase III Double-Blind, Placebo-Controlled, Add-On Study in Patients with Neuromyelitis Optica Spectrum Disorder (NMOSD)

Takashi Yamamura, Ingo Kleiter, Kazuo Fujihara, Jacqueline Palace, Benjamin Greenberg, Beata Zakrzewska-Pniewska, Francesco Patti, Ching-Piao Tsai, Albert Saiz, Masayuki Haramura, Yusuke Terada, Yuichi Kawata, Jerome De Seze

MULTIPLE SCLEROSIS JOURNAL, 26(9) NP39-NP39, Aug, 2020
MS/NMO1 Satralizumabの有効性と安全性 NMOSD患者に対する二重盲検プラセボ対照P3研究(MS/NMO 1 Efficacy and safety of satralizumab: double-blind placebo-controlled P3 studies in NMOSD patients)

荒木学, 藤原一男, 原村昌幸, 寺田悠介, 河田祐一, 山村隆, the SAkuraSky and SAkuraStar study authors and investigators

神経免疫学, 24(1) 105-105, Sep, 2019
Efficacy of satralizumab (SA237) in subgroups of patients in SAkuraSky: a Phase III double-blind, placebo-controlled, add-on study in patients with neuromyelitis optica spectrum disorder (NMOSD)

Takashi Yamamura, Ingo Kleiter, Kazuo Fujihara, Jacqueline Palace, Benjamin Greenberg, Beata Zakrzewska-Pniewska, Francesco Patti, Ching Piao Tsai, Albert Saiz, Masayuki Haramura, Yusuke Terada, Yuichi Kawata, Jerome De Seze

NEUROLOGY, 92(15), Apr, 2019
Proteomics for drug target discovery and mode-of-action analysis of drug candidates.

Haramura Masayuki, Ashihara Motooki, Inomata Noriyuki, Kato Kuniyasu, Shinkawa Takashi, Nagano Kohji, Yabuki Nami, Mutoh Hironori

Abstracts for Annual Meeting of Japanese Proteomics Society, 2012 39-39, 2012
尿タンパク質プロテオミクス解析のための各種前分画法の検討

矢吹奈美, 長野光司, 木野崎雅彦, 二瓶剛, 坪井良徳, 鈴木好幸, 新川高志, 加藤邦泰, 猪股則行, 原村昌幸

日本生化学会大会プログラム・講演要旨集, 84回 4P-0443, Sep, 2011
Proteomic analysis of urine from kidney-injured rat using various protein fractionation techniques and LC-MS analysis

Yabuki Nami, Haramura Masayuki, Nagano Kohji, Kinosaki Masahiko, Nihei Takeshi, Tsuboi Yoshinori, Suzuki Yoshiyuki, Shinkawa Takashi, Kato Kuniyasu, Inomata Noriyuki

Abstracts for Annual Meeting of Japanese Proteomics Society, 2011 159-159, 2011
New Approach to Correct SILAC Data

Inomata Noriyuki, Mutoh Hironori, Yabuki Nami, Nagano Kohji, Shinkawa Takashi, Haramura Masayuki

Abstracts for Annual Meeting of Japanese Proteomics Society, 2011 120-120, 2011
ビオチンラベル法と糖蛋白質捕捉法による細胞表面蛋白質のプロファイリング

長野光司, 新川高志, 加藤邦泰, 矢吹奈美, 猪股則行, 原村昌幸

日本臨床プロテオーム研究会要旨集, 2010 73-73, 2010
統合プロテオミクスによるシグナル伝達解析(Integrated phosphoproteomic analysis uncovers the activity state of the intracellular signaling)

長野光司, 新川高志, 矢吹奈美, 猪股則行, 渡辺祥規, 長橋茂久, 石井暢也, 青木裕子, 原村昌幸

日本生化学会大会プログラム・講演要旨集, 82回 4T15a-6, Sep, 2009
Combinatorial proteomic analysis uncovers the activity state of the intracellular signaling

Nagano Kohji, Shinkawa Takashi, Yabuki Nami, Inomata Noriyuki, Watanabe Yoshinori, Nagahashi Shigehisa, Ishii Nobuya, Aoki Yuko, Haramura Masayuki

Abstracts for Annual Meeting of Japanese Proteomics Society, 2009 45-45, 2009
Phosphoproteomic analysis of 3 distinct tumor cell lines arrested at M-phase

Nagano Kohji, Shinkawa Takashi, Kondoh Osamu, Morimoto Sayuri, Inomata Noriyuki, Ishii Nobuya, Aoki Yuko, Haramura Masayuki

Abstracts for Annual Meeting of Japanese Proteomics Society, 2008 66-66, 2008
創薬シリーズ標的探索プロテオミクスから創薬へケミカルバイオロジーの応用と展開

原村昌幸

日本薬理学雑誌, 129(2) 124-128, Feb, 2007
Optimization of Conditions for Identification of Proteins from SDS-PAGE Analysis Using LC-MS/MS

HIGASHIYAMA Kimihiko, TSUCHIYA Kouichi, HARAMURA Masayuki, TANAKA Akito

Journal of the Mass Spectrometry Society of Japan, 54(3) 109-115, Jun 1, 2006
Structure of fipexide hydrochloride monohydrate

Rumiko Tanaka, Masayuki Haramura, Akito Tanaka, Noriaki Hirayama

Analytical Sciences: X-ray Structure Analysis Online, 22(3), 2006
ゲノム工学--プロテオーム編(5)古くて新しいテーマ:アフィニティ樹脂による網羅的ターゲット探索--非特異的蛋白質の抑制

原村昌幸, 田中明人

ゲノム医学, 5(2) 191-195, Apr, 2005
Structure of etophylline

Rumiko Tanaka, Masayuki Haramura, Akito Tanaka, Noriaki Hirayama

Analytical Sciences: X-ray Structure Analysis Online, 21(10), 2005
Structure of trimetazidine

Rumiko Tanaka, Masayuki Haramura, Akito Tanaka, Noriaki Hirayama

Analytical Sciences: X-ray Structure Analysis Online, 21(1), Jan, 2005
Structure of nadolol

Rumiko Tanaka, Masayuki Haramura, Akito Tanaka, Noriaki Hirayama

Analytical Sciences: X-ray Structure Analysis Online, 21(10), 2005
Structure of guanethidine monosulfate

Rumiko Tanaka, Masayuki Haramura, Akito Tanaka, Noriaki Hirayama

Analytical Sciences: X-ray Structure Analysis Online, 21(7), 2005
Structure of pimethixene maleate

Rumiko Tanaka, Masayuki Haramura, Akito Tanaka, Noriaki Hirayama

Analytical Sciences: X-ray Structure Analysis Online, 21(10), 2005