論文

査読有り 国際誌
2020年9月

Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
  • Kazuo Fujihara
  • ,
  • Jeffrey L. Bennett
  • ,
  • Jerome de Seze
  • ,
  • Masayuki Haramura
  • ,
  • Ingo Kleiter
  • ,
  • Brian G. Weinshenker
  • ,
  • Delene Kang
  • ,
  • Tabasum Mughal
  • ,
  • Takashi Yamamura

7
5
記述言語
英語
掲載種別
DOI
10.1212/NXI.0000000000000841
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disorder that preferentially affects the spinal cord and optic nerve. Most patients with NMOSD experience severe relapses that lead to permanent neurologic disability; therefore, limiting frequency and severity of these attacks is the primary goal of disease management. Currently, patients are treated with immunosuppressants. Interleukin-6 (IL-6) is a pleiotropic cytokine that is significantly elevated in the serum and the CSF of patients with NMOSD. IL-6 may have multiple roles in NMOSD pathophysiology by promoting plasmablast survival, stimulating the production of antibodies against aquaporin-4, disrupting blood-brain barrier integrity and functionality, and enhancing proinflammatory T-lymphocyte differentiation and activation. Case series have shown decreased relapse rates following IL-6 receptor (IL-6R) blockade in patients with NMOSD, and 2 recent phase 3 randomized controlled trials confirmed that IL-6R inhibition reduces the risk of relapses in NMOSD. As such, inhibition of IL-6 activity represents a promising emerging therapy for the management of NMOSD manifestations. In this review, we summarize the role of IL-6 in the context of NMOSD.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1212/NXI.0000000000000841
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32820020
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455314
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000571198600025&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089769887&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85089769887&origin=inward

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