Haruka Wada

Profile Information

Degree: 博士（生命科学）

J-GLOBAL ID: 201201075824643290
researchmap Member ID: B000226142

External link: http://kaken.nii.ac.jp/d/r/70392181.ja.html

Research Interests

Research Areas

Committee Memberships

Apr, 2021 - Present

評議員, 日本がん免疫学会
Apr, 2020 - Present

プログラムオフィサー, AMED ゲノム・データ基盤事業部医療技術研究開発課移植医療技術開発研究事業
Jan, 2019 - Present

運営委員（シニア）, 日本免疫治療学会
Apr, 2020 - Mar, 2021

プログラム委員, 日本再生医療学会
Apr, 2018 - Mar, 2020

プログラムオフィサー, AMED 戦略推進部難病研究課免疫アレルギー疾患等実用化研究事業移植医療技術開発研究分野

Awards

Feb, 2020

江川賞, 日本免疫治療学会
Nov, 2018

一般研究賞, 日本白血病研究基金
2016

第1段審査（書面審査）委員優秀審査員表彰, 日本学術振興会
Oct, 2010

一般研究賞, 日本白血病研究基金
Dec, 2009

神奈川難病財団研究奨励賞
Sep, 2008

Young Investigators Award, APLAR
Mar, 2008

東京免疫フォーラム研究奨励賞

Papers

Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition.

Haruka Wada, Ryo Otsuka, Wilfred T V Germeraad, Tomoki Murata, Toru Kondo, Ken-Ichiro Seino

Journal for immunotherapy of cancer, 11(11), Nov, 2023 Peer-reviewedLead authorCorresponding author
Induced pluripotent stem cell-derived hematopoietic stem and progenitor cells induce mixed chimerism and donor-specific allograft tolerance.

Tomoki Murata, Naoki Hama, Tomoki Kamatani, Akihiro Mori, Ryo Otsuka, Haruka Wada, Ken-Ichiro Seino

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 23(9) 1331-1344, Sep, 2023
Augmented interferon regulatory factor 7 axis in whole tumor cell vaccines prevents tumor recurrence by inducing interferon gamma-secreting B cells

Nabeel Kajihara, Yoshino Tanaka, Riko Takeuchi, Takuto Kobayashi, Masafumi Tanji, Tsukasa Ataka, Shiho Nakano, Taisho Yamada, Akinori Takaoka, Yoshinori Hasegawa …

OncoImmunology, 12(1), May 22, 2023
Induction of allograft tolerance by adoptive transfer of donor B cells: an immune regulatory strategy for transplantation using MHC-matched iPS cells.

Tomoki Murata, Ryo Otsuka, Airi Sasaki, Tomoki Kamatani, Haruka Wada, Hisashi Yamakawa, Yoshinori Hasegawa, Ken-Ichiro Seino

International immunology, Apr 13, 2023
Interleukin-34 cancels anti-tumor immunity by PARP inhibitor.

Takayoshi Nakamura, Nabeel Kajihara, Naoki Hama, Takuto Kobayashi, Ryo Otsuka, Nanumi Han, Haruka Wada, Yoshinori Hasegawa, Nao Suzuki, Ken-Ichiro Seino

Journal of gynecologic oncology, Dec 21, 2022
Tumor-derived interleukin-34 creates an immunosuppressive and chemoresistant tumor microenvironment by modulating myeloid-derived suppressor cells in triple-negative breast cancer.

Nabeel Kajihara, Takuto Kobayashi, Ryo Otsuka, Junko Nio-Kobayashi, Tomohiro Oshino, Masato Takahashi, Seiichi Imanishi, Ari Hashimoto, Haruka Wada, Ken-Ichiro Seino

Cancer immunology, immunotherapy : CII, Sep 14, 2022
Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model.

Tomoki Kamatani, Ryo Otsuka, Tomoki Murata, Haruka Wada, Takeshi Takahashi, Akihiro Mori, Soichiro Murata, Hideki Taniguchi, Ken-Ichiro Seino

Inflammation and regeneration, 42(1) 4-4, Feb 2, 2022 Peer-reviewed
Macrophage-like iPS-derived Suppressor Cells Reduce Th1-mediated Immune Response to a Retinal Antigen.

Keitaro Hase, Kenichi Namba, Haruka Wada, Hyuma Tsuji, Aoi Maeda, Tomoki Murata, Ryo Otsuka, Daiju Iwata, Atsuhiro Kanda, Kousuke Noda …

Current eye research, 46(12) 1908-1916, Dec, 2021 Peer-reviewed
An optimized protocol for patient-derived xenograft in humanized mice to evaluate the role of IL-34 in immunotherapeutic resistance.

Nanumi Han, Hye Yoon Jang, Naoki Hama, Takuto Kobayashi, Ryo Otsuka, Haruka Wada, Ken-Ichiro Seino

STAR protocols, 2(2) 100460-100460, Jun 18, 2021 Peer-reviewed
Author Correction: Efficient generation of thymic epithelium from induced pluripotent stem cells that prolongs allograft survival.

Ryo Otsuka, Haruka Wada, Hyuma Tsuji, Airi Sasaki, Tomoki Murata, Mizuho Itoh, Muhammad Baghdadi, Ken-Ichiro Seino

Scientific reports, 11(1) 12857-12857, Jun 14, 2021 Peer-reviewed
IL-34, the rationale for its expression in physiological and pathological conditions

Ryo Otsuka, Haruka Wada, Ken-ichiro Seino

SEMINARS IN IMMUNOLOGY, 54 101517-101517, Apr, 2021 Peer-reviewed
Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after Transplantation of Human Liver Bud in Humanized Mouse Models.

Akihiro Mori, Soichiro Murata, Nao Tashiro, Tomomi Tadokoro, Satoshi Okamoto, Ryo Otsuka, Haruka Wada, Tomoki Murata, Takeshi Takahashi, Ken-Ichiro Seino …

Cells, 10(2), Feb 23, 2021 Peer-reviewed
Interleukin-34 contributes to poor prognosis in triple-negative breast cancer.

Nabeel Kajihara, Fumihito Kitagawa, Takuto Kobayashi, Haruka Wada, Ryo Otsuka, Ken-Ichiro Seino

Breast cancer (Tokyo, Japan), 27(6) 1198-1204, Nov, 2020 Peer-reviewed
Interleukin-34 Limits the Therapeutic Effects of Immune Checkpoint Blockade.

Naoki Hama, Takuto Kobayashi, Nanumi Han, Fumihito Kitagawa, Nabeel Kajihara, Ryo Otsuka, Haruka Wada, Hee-Kyung Lee, Hwanseok Rhee, Yoshinori Hasegawa …

iScience, 23(10) 101584-101584, Oct 23, 2020 Peer-reviewed
Establishment of an experimental model for MHC homo-to-hetero transplantation.

Tomoki Murata, Haruka Wada, Ryo Otsuka, Airi Sasaki, Hyuma Tsuji, Mizuho Itoh, Nanami Eguchi, Tatsuo Kawai, Ken-Ichiro Seino

Scientific reports, 10(1) 13560-13560, Aug 11, 2020 Peer-reviewed
Induction of macrophage-like immunosuppressive cells from common marmoset ES cells by stepwise differentiation with DZNep.

Hyuma Tsuji, Ryo Otsuka, Haruka Wada, Tomoki Murata, Airi Sasaki, Mizuho Itoh, Muhammad Baghdadi, Erika Sasaki, Ken-Ichiro Seino

Scientific reports, 10(1) 12625-12625, Jul 28, 2020 Peer-reviewed
Interleukin-34 expression in ovarian cancer: a possible correlation with disease progression.

Hiraku Endo, Naoki Hama, Muhammad Baghdadi, Kozo Ishikawa, Ryo Otsuka, Haruka Wada, Hiroshi Asano, Daisuke Endo, Yosuke Konno, Tatsuya Kato …

International immunology, 32(3) 175-186, Mar 7, 2020 Peer-reviewed
Efficient generation of thymic epithelium from induced pluripotent stem cells that prolongs allograft survival.

Ryo Otsuka, Haruka Wada, Hyuma Tsuji, Airi Sasaki, Tomoki Murata, Mizuho Itoh, Muhammad Baghdadi, Ken-Ichiro Seino

Scientific reports, 10(1) 224-224, Jan 14, 2020 Peer-reviewed
Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types.

Eric D Routh, Ashok K Pullikuth, Guangxu Jin, Julia Chifman, Jeff W Chou, Ralph B D'Agostino Jr, Ken-Ichiro Seino, Haruka Wada, Cristin G Print, Wei Zhang …

Frontiers in immunology, 11 57-57, 2020 Peer-reviewed
Immune reaction and regulation in transplantation based on pluripotent stem cell technology.

Ryo Otsuka, Haruka Wada, Tomoki Murata, Ken-Ichiro Seino

Inflammation and regeneration, 40(1) 12-12, 2020 Peer-reviewed

Misc.

細胞・臓器の移植に伴う免疫反応とその制御-最新の研究- MHC型一致他家iPS細胞由来組織移植に有効な免疫抑制剤併用プロトコールの構築

鎌谷智紀, 大塚亮, 村田智己, 和田はるか, 高橋武司, 森淳祐, 村田聡一郎, 谷口英樹, 清野研一郎

Organ Biology, 28(3) 75-75, Oct, 2021
死にゆくがん細胞ががん細胞ワクチン効果を発揮する

和田はるか, 梶原ナビール, 清野研一郎

日本癌学会総会記事, 80回 [P12-4], Sep, 2021
IL-34が大腸がんに与える影響の解析

小林拓斗, 韓ナヌミ, 和田はるか, 宮城洋平, 醍醐弥太郎, 醍醐弥太郎, 醍醐弥太郎, 清野研一郎

日本インターフェロン・サイトカイン学会学術集会抄録集, 85th (CD-ROM), 2021
腫瘍開始細胞は炎症環境を形成し免疫細胞を老化させて抗腫瘍応答の低下を導くことで免疫健常個体における腫瘍発生を許容させる

和田はるか, 近藤亨, 清野研一郎

日本癌学会総会記事, 79回 OJ12-8, Oct, 2020
腫瘍由来Interleukin-34を標的とした新規がん治療法の確立

羽馬直希, 小林拓斗, 韓ナヌミ, 北川郁人, 梶原ナビール, 大塚亮, 和田はるか, Lee Hee-kyung, Rhee Hwanseok, 長谷川嘉則 …

日本がん免疫学会総会プログラム・抄録集, 24回 102-102, Sep, 2020
奏効するがん細胞ワクチンの接種局所における微小環境動態の解析

和田はるか

日本がん免疫学会総会プログラム・抄録集, 24回 156-156, Sep, 2020
がん幹細胞はそれ自身が原炎症性細胞であり微小環境に免疫老化及び免疫抑制をもたらすことで健常動物における造腫瘍能を担保する(Tumor-initiating cell induce immuno-hyporesponsiveness following cellular senescence to Mφs guarantee its tumorigenesis)

和田はるか, バグダーディー・ムハンマド, 近藤亨, 清野研一郎

日本癌学会総会記事, 78回 J-1042, Sep, 2019
がん幹細胞はそれ自身が原炎症性細胞であり微小環境に免疫老化及び免疫抑制をもたらすことで健常動物における造腫瘍能を担保する

和田はるか, 村田智己, 大塚亮, 森口徹夫, バグダーディー・ムハンマド, 近藤亨, 清野研一郎

日本がん免疫学会総会プログラム・抄録集, 23回 131-131, Jul, 2019
IL-34は免疫チェックポイント阻害剤の治療効果を抑制する(IL-34 limits the therapeutic effects of immune checkpoints blockade)

バグダーディー・ムハンマド, 小林拓斗, 羽馬直希, 韓ナヌミ, 和田はるか, 八木田秀雄, 清野研一郎

日本がん免疫学会総会プログラム・抄録集, 23回 132-132, Jul, 2019
人工多能性幹細胞由来マクロファージ様免疫抑制細胞を用いたぶどう膜炎モデルの軽症化

長谷敬太郎, 南場研一, 北市伸義, 岩田大樹, 辻飛雄馬, 和田はるか, 清野研一郎, 石田晋

日本眼科学会雑誌, 123(臨増) 226-226, Mar, 2019
A potential role for Interleukin-34 in metastasis of ovarian cancers

羽馬直希, バグダーディムハンマド, 小林拓斗, 梅山悠伊, 韓ナヌミ, 和田はるか, 清野研一郎

日本免疫治療学会学術集会プログラム・抄録集, 16th, 2019
iPS細胞由来組織移植に想定される拒絶反応の精査と制御法の検討

村田智己, 和田はるか, 大塚亮, 辻飛雄馬, 佐々木愛里, 柴田悠平, 安宅司, 小林拓斗, ムハンマド・バグダーディー, 清野研一郎

移植, 53(総会臨時) 485-485, Sep, 2018
免疫健常個体において造腫瘍能を発揮する腫瘍開始細胞の免疫学的因子の同定(Tumor initiating cell in immunocompetent animal defined by immunological features)

和田はるか, Baghdadi Muhammad, 森口徹生, 近藤亨, 清野研一郎

日本癌学会総会記事, 77回 2327-2327, Sep, 2018
肺癌におけるIL-34と治療耐性、疾患進行、予後不良との関連(IL-34 correlates with therapeutic resistance, disease progression, and poor prognosis in lung cancers)

バグダーディー・ムハンマド, 和田はるか, 清野研一郎

日本がん免疫学会総会プログラム・抄録集, 22回 111-111, Jul, 2018
がん細胞ワクチンの効果発揮には死細胞でなく「死にゆく」細胞が重要である

和田はるか, 安宅司, 田中睦乃, バグダーディー・ムハンマド, 清野研一郎

日本がん免疫学会総会プログラム・抄録集, 22回 151-151, Jul, 2018
マウスiPS細胞から誘導した制御性マクロファージ様細胞によるアログラフト生着延長の検討

佐々木元, 和田はるか, 森田研, 清野研一郎, 篠原信雄

泌尿器外科, 30(6) 1067-1067, Jun, 2017
化学療法誘発性のIL-34はオートクラインの機序により化学療法耐性腫瘍細胞の生存を促進する(Chemotherapy-induced IL-34 promotes survival of chemoresistant cancer cells via autocrine mechanism)

Putra Wira Eka, Baghdadi Muhammad, 和田はるか, 清野研一郎

日本がん免疫学会総会プログラム・抄録集, 21回 115-115, Jun, 2017
腫瘍始原細胞の免疫学的な特徴(Immunological features of tumor initiating cells)

和田はるか, Baghdadi Muhammad, 清野研一郎

日本がん免疫学会総会プログラム・抄録集, 21回 121-121, Jun, 2017
多発性骨髄腫においてIL-34は破骨細胞の形成を促進し骨疾患を増悪化させる(IL-34 promotes ostelcclast formation and enhances bone disease in multiple myeloma)

Baghdadi Muhammad, 石川浩三, 和田はるか, 清野研一郎

日本がん免疫学会総会プログラム・抄録集, 21回 145-145, Jun, 2017
肺がんにおいてIL-34とM-CSFの共発現が予後に及ぼす影響(Prognostic significance of IL-34 and M-CSF co-expression in lung cancers)

遠藤拓, Baghdadi Muhammad, 石川浩三, 和田はるか, 清野研一郎, 鈴木直, 宮城洋平, 横瀬智之, 高野淳, 醍醐弥太郎

日本がん免疫学会総会プログラム・抄録集, 21回 120-120, Jun, 2017

Research Projects

T前駆細胞由来樹状細胞は制御性T細胞の生成を介し自己免疫寛容の構築に寄与するか

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

和田はるか
iPS細胞由来造血幹・前駆細胞（iHSPC）を用いた免疫制御法の開発

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

清野研一郎, 和田はるか
Fundamental research on effecitive whole-tumor-cell vaccine

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

WADA Haruka
A study for immune-regulation overcoming allogeneic spacio-temporal barrier using iPS cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Seino Ken-ichiro
Verification of a new hypothesis that cancer stem cells induce immune cell senescence-related immunosuppression and exert tumorigenicity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

WADA HARUKA
Induction of thyme epithelial cells from iPS cells and application to allogenic transplantation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Seino Ken-ichiro
A molecular mechanism of cancer vaccine enhancement

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Seino Ken-ichiro, WADA Haruka
What is the authentic tumor initiating cells in healthy mice?

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Wada Haruka
多能性幹細胞を用いた新時代移植医療における新しい免疫寛容誘導法の開発

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

和田はるか
A novel cancer vaccine produced with cell reprogramming

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

SEINO kenichiro, WADA Haruka
A new strategy for tumor immunotherapy using cell reprogramming technology

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

WADA Haruka, SEINO Ken-ichiro
Novel analysis method of hematopoiesis applying to embryonic lethal mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

WADA Haruka
A novel immune regulation mechanism by Ca-independent PLA2 and its contribution to neurodegenerative diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

SEINO Ken-Ichiro, WADA Haruka, KOJO Satoshi

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