haruo kasai

J-GLOBAL         Last updated: Sep 29, 2019 at 16:14
 
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Name
haruo kasai
Research funding number
60224375

Profile

Neuronal circuits made by synapses in the brain enable learning, memory, perception, emotion, and their impairment results in various mental disorders. We perform research that extensively utilize microscopic methods to observe cellular and molecular events deep within the brain, and which allow labeling of potentiated synapses and optical manipulation of synapses and circuits. We have shown that cerebral spine synapses undergo rapid enlargement during potentiation in the hippocampus, neocortex and basal ganglia. Such dynamic synaptic motilities are the sites of endogenous neuromodulation, therapeutic agents and addictive drugs. Moreover, the dynamic nature of synapses has allowed us to construct new optical and molecular probes for a better understanding of learning and cognition and their impairments.

Research Interests

 
 

Academic & Professional Experience

 
Apr 1981
 - 
Mar 1985
Graduate School of Medicine, The University of Tokyo
 
Dec 1987
 - 
Jun 1990
Humboldt Fellow, Max-Planck Institute for Biopyhsical Chemistry
 

Awards & Honors

 
Apr 2018
Medal with Purple Ribbon
 

Published Papers

 
Noguchi, J., Nagaoka A.,,Hayama, T., Ucar H.,,Yagishita, S.,Takahashi, N., & Kasa, H.
Sci Rep.   9 13922   Sep 2019   [Refereed]
Humble, J., Hiratsuka, K., Kasai, H. & Toyoizumi, T.
Frontiers in Computational Neuroscience   13 A38   Jun 2019   [Refereed]
Park, I. Kim, H. J. Kim, Y. Hwang, H. S. Kasai, H. Kim, J. H. Park, J. W.
Proc Natl Acad Sci U S A   116(19) 9616-9621   Apr 2019   [Refereed]
Moda-Sava, R. N. Murdock, M. H. Parekh, P. K. Fetcho, R. N. Huang, B. S. Huynh, T. N. Witztum, J. Shaver, D. C. Rosenthal, D. L. Alway, E. J. Lopez, K. Meng, Y. Nellissen, L. Grosenick, L. Milner, T. A. Deisseroth, K. Bito, H. Kasai, H. Liston, C.
Science   364(6436) eaat8078   Apr 2019   [Refereed]
Tainaka, K., Murakami, T.C., Susaki, E.A., Shimizu, C., Saito, R., Takahashi, K., Hayashi-Takagi, A., Sekiya, H., Arima, Y., Nojima, S., Ikemura, M., Ushiku, T., Shimizu, Y., Murakami, M., Tanaka, K.F., Iino, M., Kasai, H., Sasaoka, T., Kobayashi, K., Miyazono, K., Morii, E., Isa, T., Fukayama, M., Kakita, A. & Ueda, H.R.
Cell Reports   24(8) 2196-2210   Aug 2018   [Refereed]
Okazaki,H., Hayashi-Takagi, A., Nagaoka, A., Negishi, M., Ucar, H., Yagishita, S., Ishii, K., Toyoizumi, T., Fox, K., & Kasai, H.
Neurosci Lett   671 99-102   Apr 2018   [Refereed]
Tse, A, Lee, A.K., Takahashi, N.,Gong, A., Kasai, H. & Tse, F.W.
J. Neurogenetics   32(3) 267-278   Dec 2018   [Refereed]
Dagliyan, O., Karginov, A., Yagishita, S., Gale, M., Wang, H., DerMardirossian, C., Wells, C., Dokholyan, N., Kasai, H. & Hahn, K.
ACS Synthetic Biology   6 1257-1262   Apr 2017   [Refereed]
Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura S.-I, Sato K, Harada R, Kim Y.-J, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.
Journal of Cell Biology   215(1) 121-138   Oct 2016   [Refereed]
Nagaoka, A., Takehara, H., Hayashi-Takagi, A., Shirai, F., Ishii, K., Noguchi, J., Ichiki, K. & Kasai, H.
Sci. Rep.   6 26651   May 2016   [Refereed]
Miyazaki J, Iida T, Tanaka S, Hayashi-Takagi A, Kasai H, Okabe S, Kobayashi T.
Biomedical Optics Express   7(5) 1702-1710   2016   [Refereed]
Takehara H, Nagaoka A, Noguchi J, Akagi T, Kasai H, Ichiki T.
Journal of Photopolymer Science and Technology   29(4) 513-518   2016   [Refereed]
Noguchi J, Hayama T, Watanabe S, Ucar H, Yagishita S, Takahashi N, Kasai H.
Scientific Reports   6    2016   [Refereed]
Jakkampudi, S., Abe, M.*, Komori, N., Takagi, R., Furukawa, K., Katan, C., Sawada, W., Takahashi, N. & Kasai, H.
ACS Omega   1(2) 193-201   2016   [Refereed]
Komori N, Jakkampudi S, Motoishi R, Abe M, Kamada K, Furukawa K, Katan C, Sawada W, Takahashi N, Kasai H, Xue B, Kobayashi T.
Chemical Communications   52(2) 331-334   2015   [Refereed]
Kasai H, Hatakeyama H, Ohno M, Takahashi N.
Islets of Langerhans, Second Edition   475-510   2015   [Refereed]
Hayashi-Takagi A, Yagishita S, Nakamura M, Shirai F, Wu Y.I, Loshbaugh A.L, Kuhlman B, Hahn K.M, Kasai H.
Nature   525(7569) 333-338   2015   [Refereed]
Takahashi N, Sawada W, Noguchi J, Watanabe S, Ucar H, Hayashi-Takagi A, Yagishita S, Ohno M, Tokumaru H, Kasai H.
Nature Communications   6    2015   [Refereed]
Yagishita S, Hayashi-Takagi A, Ellis-Davies G.C.R, Urakubo H, Ishii S, Kasai H.
Science   345(6204) 1616-1620   2014   [Refereed]
Boinapally S, Huang B, Abe M, Katan C, Noguchi J, Watanabe S, Kasai H, Xue B, Kobayashi T.
Journal of Organic Chemistry   79(17) 7822-7830   2014   [Refereed]
Takehara H, Nagaoka A, Noguchi J, Akagi T, Kasai H, Ichiki T.
Scientific Reports   4    2014   [Refereed]
Hayashi-Takagi A, Araki Y, Nakamura M, Vollrath B, Duron S.G, Yan Z, Kasai H, Huganir R.L, Campbell D.A, Sawa A.
Proceedings of the National Academy of Sciences of the United States of America   111(17) 6461-6466   2014   [Refereed]
Miyazaki J, Tsurui H, Hayashi-Takagi A, Kasai H, Kobayashi T.
Optics Express   22(8) 9024-9032   2014   [Refereed]
Nuriya M, Momotake A, Kimura Y, Yasui M, Kasai H, Arai T.
Bulletin of the Chemical Society of Japan   86(10) 1190-1192   2013   [Refereed]
Hayama T, Noguchi J, Watanabe S, Takahashi N, Hayashi-Takagi A, Ellis-Davies G.C.R, Matsuzaki M, Kasai H.
Nature Neuroscience   16(10) 1409-1416   2013   [Refereed]
Takehara H, Nagaoka A, Noguchi J, Akagi T, Sakai T, Chung U, Kasai H, Ichiki T.
Biomicrofluidics   7(5)    2013   [Refereed]
Hira R, Ohkubo F, Tanaka Y.R, Masamizu Y, Augustine G.J, Kasai H, Matsuzaki M.
Frontiers in Neural Circuits   (MAR)    2013   [Refereed]
Lam P.P.L, Ohno M, Dolai S, He Y, Qin T, Liang T, Zhu D, Kang Y, Liu Y, Kauppi M, Xie L, Wan W.C.Y, Bin N.-R, Sugita S, Olkkonen V.M, Takahashi N, Kasai H, Gaisano H.Y.
Diabetes   62(7) 2416-2428   2013   [Refereed]
Asrican B, Augustine G.J, Berglund K, Chen S, Chow N, Deisseroth K, Feng G, Gloss B, Hira R, Hoffmann C, Kasai H, Katarya M, Kim J, Kudolo J, Lee L.M, Lo S.Q, Mancuso J, Matsuzaki M, Nakajima R, Qiu L, Tan G, Tang Y, Ting J.T, Tsuda S, Wen L, Zhang X, Zhao S.
Frontiers in Neural Circuits   7(NOV)    2013   [Refereed]
Hira R, Ohkubo F, Ozawa K, Isomura Y, Kitamura K, Kano M, Kasai H, Matsuzaki M.
Journal of Neuroscience   33(4) 1377-1390   2013   [Refereed]
Ogata S, Miki T, Seino S, Tamai S, Kasai H, Nemoto T.
PLoS ONE   7(5)    2012   [Refereed]
Kasai H, Takahashi N, Tokumaru H.
Physiological Reviews   92(4) 1915-1964   2012   [Refereed]
Kimura Y, Momotake A, Takahashi N, Kasai H, Arai T.
Chemistry Letters   41(5) 528-530   2012   [Refereed]
Cai T, Hirai H, Zhang G, Zhang M, Takahashi N, Kasai H, Satin L.S, Leapman R.D, Notkins A.L.
Diabetologia   54(9) 2347-2357   2011   [Refereed]
Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M. & Kasai H.
J.Physiol.   589(10) 2320-2329   2011   [Refereed]
Ako R, Wakimoto M, Ebisu H, Tanno K, Hira R, Kasai H, Matsuzaki M, Kawasaki H.
Molecular and Cellular Neuroscience   48(3) 246-257   2011   [Refereed]
Kanemoto Y, Matsuzaki M, Morita S, Hayama T, Noguchi J, Senda N, Momotake A, Arai T, Kasai H.
PLoS ONE   6(7)    2011   [Refereed]
Matsuzaki M, Kasai H.
Cold Spring Harbor Protocols   6(5)    2011   [Refereed]
Kasai H, Hayama T, Ishikawa M, Watanabe S, Yagishita S, Noguchi J.
European Journal of Neuroscience   32(2) 241-249.   Jul 2010   [Refereed][Invited]
Takahashi N, Hatakeyama H, Okado H, Noguchi J, Ohno M, Kasai H.
Cell Metabolism   12(1) 19-29   Jul 2010   [Refereed]
Matsuzaki M, Hayama T, Kasai H, Ellis-Davies GC
Nature chemical biology   6(4) 255-257   Apr 2010   [Refereed]
Kasai H, Fukuda M, Watanabe S, Hayashi-Takagi A, Noguchi J
Trends in neurosciences   33(3) 121-129   Mar 2010   [Refereed]
Kantevari S, Matsuzaki M, Kanemoto Y, Kasai H, Ellis-Davies GC
Nature methods   7(2) 123-125   Feb 2010   [Refereed]
Obi N, Momotake A, Kanemoto Y, Matsuzaki M, Kasai H, Arai T.
Tetrahedron Letters   51(13) 1642-1647   2010   [Refereed]
Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni R.N, Kahn C.R, Kasai H, Cantley L.C, Kadowaki T.
Cell Metabolism   12(6) 619-632   2010   [Refereed]
Kasai H, Hatakeyama H, Ohno M, Takahashi N
Advances in experimental medicine and biology   654 305-338   2010   [Refereed]
Hira R, Honkura N, Noguchi J, Maruyama Y, Augustine GJ, Kasai H, Matsuzaki M
Journal of neuroscience methods   179(2) 258-263   May 2009   [Refereed]
Morita S, Yasumatsu N, Noguchi J, Kasai H.
Communicative and Integrative Biology   2(6) 526-529   2009   [Refereed]
Yasumatsu N, Matsuzaki M, Miyazaki T, Noguchi J, Kasai H
The Journal of neuroscience : the official journal of the Society for Neuroscience   28(50) 13592-13608   Dec 2008   [Refereed]
Tanaka J, Horiike Y, Matsuzaki M, Miyazaki T, Ellis-Davies GC, Kasai H
Science (New York, N.Y.)   319(5870) 1683-1687   Mar 2008   [Refereed]