haruo kasai Last updated: Sep 29, 2019 at 16:14
Name
haruo kasai Research funding number
60224375
Profile Neuronal circuits made by synapses in the brain enable learning, memory, perception, emotion, and their impairment results in various mental disorders. We perform research that extensively utilize microscopic methods to observe cellular and molecular events deep within the brain, and which allow labeling of potentiated synapses and optical manipulation of synapses and circuits. We have shown that cerebral spine synapses undergo rapid enlargement during potentiation in the hippocampus, neocortex and basal ganglia. Such dynamic synaptic motilities are the sites of endogenous neuromodulation, therapeutic agents and addictive drugs. Moreover, the dynamic nature of synapses has allowed us to construct new optical and molecular probes for a better understanding of learning and cognition and their impairments.
Academic & Professional Experience
Apr 1981
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Mar 1985
Graduate School of Medicine, The University of Tokyo
Dec 1987
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Jun 1990
Humboldt Fellow, Max-Planck Institute for Biopyhsical Chemistry
Awards & Honors
Apr 2018
Medal with Purple Ribbon
Published Papers
Noguchi, J., Nagaoka A.,,Hayama, T., Ucar H.,,Yagishita, S.,Takahashi, N., & Kasa, H.
Sci Rep. 9 13922 Sep 2019 [Refereed]
Humble, J., Hiratsuka, K., Kasai, H. & Toyoizumi, T.
Frontiers in Computational Neuroscience 13 A38 Jun 2019 [Refereed]
Park, I. Kim, H. J. Kim, Y. Hwang, H. S. Kasai, H. Kim, J. H. Park, J. W.
Proc Natl Acad Sci U S A 116(19) 9616-9621 Apr 2019 [Refereed]
Moda-Sava, R. N. Murdock, M. H. Parekh, P. K. Fetcho, R. N. Huang, B. S. Huynh, T. N. Witztum, J. Shaver, D. C. Rosenthal, D. L. Alway, E. J. Lopez, K. Meng, Y. Nellissen, L. Grosenick, L. Milner, T. A. Deisseroth, K. Bito, H. Kasai, H. Liston, C.
Science 364(6436) eaat8078 Apr 2019 [Refereed]
Tainaka, K., Murakami, T.C., Susaki, E.A., Shimizu, C., Saito, R., Takahashi, K., Hayashi-Takagi, A., Sekiya, H., Arima, Y., Nojima, S., Ikemura, M., Ushiku, T., Shimizu, Y., Murakami, M., Tanaka, K.F., Iino, M., Kasai, H., Sasaoka, T., Kobayashi, K., Miyazono, K., Morii, E., Isa, T., Fukayama, M., Kakita, A. & Ueda, H.R.
Cell Reports 24(8) 2196-2210 Aug 2018 [Refereed]
Okazaki,H., Hayashi-Takagi, A., Nagaoka, A., Negishi, M., Ucar, H., Yagishita, S., Ishii, K., Toyoizumi, T., Fox, K., & Kasai, H.
Neurosci Lett 671 99-102 Apr 2018 [Refereed]
Tse, A, Lee, A.K., Takahashi, N.,Gong, A., Kasai, H. & Tse, F.W.
J. Neurogenetics 32(3) 267-278 Dec 2018 [Refereed]
Dagliyan, O., Karginov, A., Yagishita, S., Gale, M., Wang, H., DerMardirossian, C., Wells, C., Dokholyan, N., Kasai, H. & Hahn, K.
ACS Synthetic Biology 6 1257-1262 Apr 2017 [Refereed]
Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura S.-I, Sato K, Harada R, Kim Y.-J, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.
Journal of Cell Biology 215(1) 121-138 Oct 2016 [Refereed]
Nagaoka, A., Takehara, H., Hayashi-Takagi, A., Shirai, F., Ishii, K., Noguchi, J., Ichiki, K. & Kasai, H.
Sci. Rep. 6 26651 May 2016 [Refereed]
Miyazaki J, Iida T, Tanaka S, Hayashi-Takagi A, Kasai H, Okabe S, Kobayashi T.
Biomedical Optics Express 7(5) 1702-1710 2016 [Refereed]
Takehara H, Nagaoka A, Noguchi J, Akagi T, Kasai H, Ichiki T.
Journal of Photopolymer Science and Technology 29(4) 513-518 2016 [Refereed]
Noguchi J, Hayama T, Watanabe S, Ucar H, Yagishita S, Takahashi N, Kasai H.
Scientific Reports 6 2016 [Refereed]
Jakkampudi, S., Abe, M.*, Komori, N., Takagi, R., Furukawa, K., Katan, C., Sawada, W., Takahashi, N. & Kasai, H.
ACS Omega 1(2) 193-201 2016 [Refereed]
Komori N, Jakkampudi S, Motoishi R, Abe M, Kamada K, Furukawa K, Katan C, Sawada W, Takahashi N, Kasai H, Xue B, Kobayashi T.
Chemical Communications 52(2) 331-334 2015 [Refereed]
Kasai H, Hatakeyama H, Ohno M, Takahashi N.
Islets of Langerhans, Second Edition 475-510 2015 [Refereed]
Hayashi-Takagi A, Yagishita S, Nakamura M, Shirai F, Wu Y.I, Loshbaugh A.L, Kuhlman B, Hahn K.M, Kasai H.
Nature 525(7569) 333-338 2015 [Refereed]
Takahashi N, Sawada W, Noguchi J, Watanabe S, Ucar H, Hayashi-Takagi A, Yagishita S, Ohno M, Tokumaru H, Kasai H.
Nature Communications 6 2015 [Refereed]
Yagishita S, Hayashi-Takagi A, Ellis-Davies G.C.R, Urakubo H, Ishii S, Kasai H.
Science 345(6204) 1616-1620 2014 [Refereed]
Boinapally S, Huang B, Abe M, Katan C, Noguchi J, Watanabe S, Kasai H, Xue B, Kobayashi T.
Journal of Organic Chemistry 79(17) 7822-7830 2014 [Refereed]
Takehara H, Nagaoka A, Noguchi J, Akagi T, Kasai H, Ichiki T.
Scientific Reports 4 2014 [Refereed]
Hayashi-Takagi A, Araki Y, Nakamura M, Vollrath B, Duron S.G, Yan Z, Kasai H, Huganir R.L, Campbell D.A, Sawa A.
Proceedings of the National Academy of Sciences of the United States of America 111(17) 6461-6466 2014 [Refereed]
Miyazaki J, Tsurui H, Hayashi-Takagi A, Kasai H, Kobayashi T.
Optics Express 22(8) 9024-9032 2014 [Refereed]
Nuriya M, Momotake A, Kimura Y, Yasui M, Kasai H, Arai T.
Bulletin of the Chemical Society of Japan 86(10) 1190-1192 2013 [Refereed]
Hayama T, Noguchi J, Watanabe S, Takahashi N, Hayashi-Takagi A, Ellis-Davies G.C.R, Matsuzaki M, Kasai H.
Nature Neuroscience 16(10) 1409-1416 2013 [Refereed]
Takehara H, Nagaoka A, Noguchi J, Akagi T, Sakai T, Chung U, Kasai H, Ichiki T.
Biomicrofluidics 7(5) 2013 [Refereed]
Hira R, Ohkubo F, Tanaka Y.R, Masamizu Y, Augustine G.J, Kasai H, Matsuzaki M.
Frontiers in Neural Circuits (MAR) 2013 [Refereed]
Lam P.P.L, Ohno M, Dolai S, He Y, Qin T, Liang T, Zhu D, Kang Y, Liu Y, Kauppi M, Xie L, Wan W.C.Y, Bin N.-R, Sugita S, Olkkonen V.M, Takahashi N, Kasai H, Gaisano H.Y.
Diabetes 62(7) 2416-2428 2013 [Refereed]
Asrican B, Augustine G.J, Berglund K, Chen S, Chow N, Deisseroth K, Feng G, Gloss B, Hira R, Hoffmann C, Kasai H, Katarya M, Kim J, Kudolo J, Lee L.M, Lo S.Q, Mancuso J, Matsuzaki M, Nakajima R, Qiu L, Tan G, Tang Y, Ting J.T, Tsuda S, Wen L, Zhang X, Zhao S.
Frontiers in Neural Circuits 7(NOV) 2013 [Refereed]
Hira R, Ohkubo F, Ozawa K, Isomura Y, Kitamura K, Kano M, Kasai H, Matsuzaki M.
Journal of Neuroscience 33(4) 1377-1390 2013 [Refereed]
Ogata S, Miki T, Seino S, Tamai S, Kasai H, Nemoto T.
PLoS ONE 7(5) 2012 [Refereed]
Kasai H, Takahashi N, Tokumaru H.
Physiological Reviews 92(4) 1915-1964 2012 [Refereed]
Kimura Y, Momotake A, Takahashi N, Kasai H, Arai T.
Chemistry Letters 41(5) 528-530 2012 [Refereed]
Cai T, Hirai H, Zhang G, Zhang M, Takahashi N, Kasai H, Satin L.S, Leapman R.D, Notkins A.L.
Diabetologia 54(9) 2347-2357 2011 [Refereed]
Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M. & Kasai H.
J.Physiol. 589(10) 2320-2329 2011 [Refereed]
Ako R, Wakimoto M, Ebisu H, Tanno K, Hira R, Kasai H, Matsuzaki M, Kawasaki H.
Molecular and Cellular Neuroscience 48(3) 246-257 2011 [Refereed]
Kanemoto Y, Matsuzaki M, Morita S, Hayama T, Noguchi J, Senda N, Momotake A, Arai T, Kasai H.
PLoS ONE 6(7) 2011 [Refereed]
Matsuzaki M, Kasai H.
Cold Spring Harbor Protocols 6(5) 2011 [Refereed]
Kasai H, Hayama T, Ishikawa M, Watanabe S, Yagishita S, Noguchi J.
European Journal of Neuroscience 32(2) 241-249. Jul 2010 [Refereed][Invited]
Takahashi N, Hatakeyama H, Okado H, Noguchi J, Ohno M, Kasai H.
Cell Metabolism 12(1) 19-29 Jul 2010 [Refereed]
Matsuzaki M, Hayama T, Kasai H, Ellis-Davies GC
Nature chemical biology 6(4) 255-257 Apr 2010 [Refereed]
Kasai H, Fukuda M, Watanabe S, Hayashi-Takagi A, Noguchi J
Trends in neurosciences 33(3) 121-129 Mar 2010 [Refereed]
Kantevari S, Matsuzaki M, Kanemoto Y, Kasai H, Ellis-Davies GC
Nature methods 7(2) 123-125 Feb 2010 [Refereed]
Obi N, Momotake A, Kanemoto Y, Matsuzaki M, Kasai H, Arai T.
Tetrahedron Letters 51(13) 1642-1647 2010 [Refereed]
Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni R.N, Kahn C.R, Kasai H, Cantley L.C, Kadowaki T.
Cell Metabolism 12(6) 619-632 2010 [Refereed]
Kasai H, Hatakeyama H, Ohno M, Takahashi N
Advances in experimental medicine and biology 654 305-338 2010 [Refereed]
Hira R, Honkura N, Noguchi J, Maruyama Y, Augustine GJ, Kasai H, Matsuzaki M
Journal of neuroscience methods 179(2) 258-263 May 2009 [Refereed]
Morita S, Yasumatsu N, Noguchi J, Kasai H.
Communicative and Integrative Biology 2(6) 526-529 2009 [Refereed]
Yasumatsu N, Matsuzaki M, Miyazaki T, Noguchi J, Kasai H
The Journal of neuroscience : the official journal of the Society for Neuroscience 28(50) 13592-13608 Dec 2008 [Refereed]
Tanaka J, Horiike Y, Matsuzaki M, Miyazaki T, Ellis-Davies GC, Kasai H
Science (New York, N.Y.) 319(5870) 1683-1687 Mar 2008 [Refereed]
