2005年5月
Spine-neck geometry determines NMDA receptor-dependent Ca2+ signaling in dendrites
NEURON
- ,
- ,
- ,
- 巻
- 46
- 号
- 4
- 開始ページ
- 609
- 終了ページ
- 622
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2005.03.015
- 出版者・発行元
- CELL PRESS
Increases in cytosolic Ca2+ concentration ([Ca2+](i)) mediated by NMDA-sensitive glutamate receptors (NMDARs) are important for synaptic plasticity. We studied a wide variety of dendritic spines on rat CA1 pyramidal neurons in acute hippocampal slices. Two-photon uncaging and Ca2+ imaging revealed that NMDAR-mediated currents increased with spine-head volume and that even the smallest spines contained a significant number of NMDARs. The fate of Ca2+ that entered spine heads through NMDARs was governed by the shape (length and radius) of the spine neck. Larger spines had necks that permitted greater efflux of Ca2+ into the dendritic shaft, whereas smaller spines manifested a larger increase in [Ca2+](i) within the spine compartment as a result of a smaller Ca2+ flux through the neck. Spine-neck geometry is thus an important determinant of spine Ca2+ signaling, allowing small spines to be the preferential sites for isolated induction of long-term potentiation.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.neuron.2005.03.015
- CiNii Articles
- http://ci.nii.ac.jp/naid/30010680678
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15944129
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000229294300012&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-20444369248&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0003-2327-9027
- ID情報
-
- DOI : 10.1016/j.neuron.2005.03.015
- ISSN : 0896-6273
- CiNii Articles ID : 30010680678
- ORCIDのPut Code : 19717500
- PubMed ID : 15944129
- SCOPUS ID : 20444369248
- Web of Science ID : WOS:000229294300012