1999年12月
Supralinear Ca2+ signaling by cooperative and mobile Ca2+ buffering in Purkinje neurons
NEURON
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- ,
- ,
- ,
- 巻
- 24
- 号
- 4
- 開始ページ
- 989
- 終了ページ
- 1002
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0896-6273(00)81045-4
- 出版者・発行元
- CELL PRESS
Endogenous high-affinity Ca2+ buffering and its roles were investigated in mouse cerebellar Purkinje cells with the use of a low-affinity Ca2+ indicator and a high-affinity caged Ca2+ compound. Increases in the cytosolic Ca2+ concentration ([Ca2+](i)) were markedly facilitated during repetitive depolarization, resulting in the generation of steep micromolar Ca2+ gradients along dendrites. Such supralinear Ca2+ responses were attributed to the saturation of a large concentration (0.36 mM) of a mobile, high-affinity (dissociation constant, 0.37 mu M) Ca2+ buffer with cooperative Ca2+ binding sites, resembling calbindin-D-28K, and to an immobile, low-affinity Ca2+ buffer. These data suggest that the high-affinity Ca2+ buffer operates as the neuronal computational element that enables efficient coincidence detection of the Ca2+ signal and that facilitates spatiotemporal integration of the Ca2+ signal at submicromolar [Ca2+](i).
- リンク情報
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- DOI
- https://doi.org/10.1016/S0896-6273(00)81045-4
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000084495300026&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-0033257453&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0003-2327-9027
- ID情報
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- DOI : 10.1016/S0896-6273(00)81045-4
- ISSN : 0896-6273
- ORCIDのPut Code : 19717522
- SCOPUS ID : 0033257453
- Web of Science ID : WOS:000084495300026