haruo kasai
(河西 春郎)
Modified on: 02/01
Profile Information
- Affiliation
- WPI-IRCN, The University of Tokyo
- Degree
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医学博士
- Researcher number
- 60224375
- J-GLOBAL ID
- 200901061634321923
- researchmap Member ID
- 1000255221
- External link
Neuronal circuits made by synapses in the brain enable learning, memory, perception, emotion, and their impairment results in various mental disorders. We perform research that extensively utilize microscopic methods to observe cellular and molecular events deep within the brain, and which allow labeling of potentiated synapses and optical manipulation of synapses and circuits. We have shown that cerebral spine synapses undergo rapid enlargement during potentiation in the hippocampus, neocortex and basal ganglia. Such dynamic synaptic motilities are the sites of endogenous neuromodulation, therapeutic agents and addictive drugs. Moreover, the dynamic nature of synapses has allowed us to construct new optical and molecular probes for a better understanding of learning and cognition and their impairments.
Research Interests
20Research Areas
2Research History
7-
Apr, 2023 - Present
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Oct, 2005 - Mar, 2022
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Dec, 1999 - Sep, 2005
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Nov, 1993 - Nov, 1998
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Jun, 1990 - Oct, 1993
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Dec, 1987 - Jun, 1990
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Apr, 1981 - Mar, 1985
Awards
5-
Apr, 2018
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Nov, 2016
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Dec, 2010
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Oct, 2002
Major Papers
169-
Proceedings of the Japan Academy, Series B, 99(8) 254-305, Oct 11, 2023 Peer-reviewedInvitedLead authorCorresponding author
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Current Opinion in Neurobiology, 80 102706-102706, Jun, 2023 Peer-reviewedInvitedLead authorCorresponding author
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Nature, 600(7890) 686-689, Dec 23, 2021 Peer-reviewedCorresponding author
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Nature Reviews Neuroscience, 22(7) 407-422, Jul, 2021 Peer-reviewedInvitedLead authorCorresponding author
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Nature, 579(7800) 555-560, Mar, 2020 Peer-reviewedCorresponding author
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Scientific reports, 9(1) 13922-13922, Sep 26, 2019 Peer-reviewedLast authorCorresponding author
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Frontiers in Computational Neuroscience, 13 A38, Jun, 2019 Peer-reviewed
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Science, 364(6436) eaat8078, Apr, 2019 Peer-reviewed
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eNeuro, 5(5) e0282-18.2018, Oct, 2018 Peer-reviewedLast authorCorresponding author
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ENEURO, 18(0282), Oct, 2018 Peer-reviewedLast authorCorresponding author
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Neuroscience Letters, 671 99-102, Apr 3, 2018 Peer-reviewedLast authorCorresponding author
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SCIENTIFIC REPORTS, 6, Sep, 2016 Peer-reviewedLast authorCorresponding author
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SCIENTIFIC REPORTS, 6 26651, May, 2016 Peer-reviewedLast authorCorresponding author
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NATURE COMMUNICATIONS, 6, Oct, 2015 Peer-reviewedLast authorCorresponding author
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NATURE, 525(7569) 333-+, Sep, 2015 Peer-reviewedLast authorCorresponding author
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SCIENCE, 345(6204) 1616-1620, Sep, 2014 Peer-reviewedLast authorCorresponding author
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NATURE NEUROSCIENCE, 16(10) 1409-+, Oct, 2013 Peer-reviewedLast authorCorresponding author
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PHYSIOLOGICAL REVIEWS, 92(4) 1915-1964, Oct, 2012 Peer-reviewedLast authorCorresponding author
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The Journal of Physiology, 589(10) 2447-2457, May 15, 2011
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CELL METABOLISM, 12(1) 19-29, Jul, 2010 Peer-reviewedLast authorCorresponding author
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EUROPEAN JOURNAL OF NEUROSCIENCE, 32(2) 241-249, Jul, 2010 Peer-reviewedInvitedLast authorCorresponding author
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NATURE CHEMICAL BIOLOGY, 6(4) 255-257, Apr, 2010 Peer-reviewed
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TRENDS IN NEUROSCIENCES, 33(3) 121-129, Mar, 2010 Peer-reviewedLast authorCorresponding author
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NATURE METHODS, 7(2) 123-U51, Feb, 2010 Peer-reviewedCorresponding author
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JOURNAL OF NEUROSCIENCE, 28(50) 13592-13608, Dec, 2008 Peer-reviewedLast authorCorresponding author
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SCIENCE, 319(5870) 1683-1687, Mar, 2008 Peer-reviewedLast authorCorresponding author
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The subspine organization of actin fibers regulates the structure and plasticity of dendritic spinesNEURON, 57(5) 719-729, Mar, 2008 Peer-reviewedLast authorCorresponding author
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JOURNAL OF PHYSIOLOGY-LONDON, 582(3) 1087-1098, Aug, 2007 Peer-reviewedLast authorCorresponding author
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EMBO JOURNAL, 25(4) 673-682, Feb, 2006 Peer-reviewedLast authorCorresponding author
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JOURNAL OF PHYSIOLOGY-LONDON, 570(2) 271-282, Jan, 2006 Peer-reviewedCorresponding author
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JOURNAL OF PHYSIOLOGY-LONDON, 568(3) 917-929, Nov, 2005 Peer-reviewedLast authorCorresponding author
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JOURNAL OF PHYSIOLOGY-LONDON, 568(3) 905-915, Nov, 2005 Peer-reviewedLast authorCorresponding author
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JOURNAL OF PHYSIOLOGY-LONDON, 568(3) 891-903, Nov, 2005 Peer-reviewedLead authorCorresponding author
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NEURON, 46(4) 609-622, May, 2005 Peer-reviewedLast authorCorresponding author
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CELL CALCIUM, 37(4) 359-370, Apr, 2005 Peer-reviewedLast authorCorresponding author
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JOURNAL OF NEUROSCIENCE, 25(4) 799-807, Jan, 2005 Peer-reviewed
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JOURNAL OF BIOLOGICAL CHEMISTRY, 279(36) 37544-37550, Sep, 2004 Peer-reviewedLast authorCorresponding author
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NATURE, 429(6993) 761-766, Jun, 2004 Peer-reviewedLast authorCorresponding author
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JOURNAL OF CELL BIOLOGY, 165(2) 255-262, Apr, 2004 Peer-reviewed
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TRENDS IN NEUROSCIENCES, 26(7) 360-368, Jul, 2003 Peer-reviewed
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Science, 297(5585) 1349-1352, Aug 23, 2002 Peer-reviewedCorresponding author
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NATURE NEUROSCIENCE, 4(11) 1086-1092, Nov, 2001 Peer-reviewedLast authorCorresponding author
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JOURNAL OF PHYSIOLOGY-LONDON, 533(3) 627-637, Jun, 2001 Peer-reviewedLast authorCorresponding author
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NATURE CELL BIOLOGY, 3(3) 253-258, Mar, 2001 Peer-reviewedLast authorCorresponding author
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NEURON, 24(4) 989-1002, Dec, 1999 Peer-reviewedLast authorCorresponding author
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JOURNAL OF CELL BIOLOGY, 146(2) 405-413, Jul, 1999 Peer-reviewedLast authorCorresponding author
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(3) 945-949, Feb, 1999 Peer-reviewedLast authorCorresponding author
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TRENDS IN NEUROSCIENCES, 22(2) 88-93, Feb, 1999 Peer-reviewedLead authorLast authorCorresponding author
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(2) 760-765, Jan, 1999 Peer-reviewedLast authorCorresponding author
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JOURNAL OF CELL BIOLOGY, 138(1) 55-64, Jul, 1997 Peer-reviewedLast authorCorresponding author
Presentations
22-
Keynote Lecture, Optogenetics Gordon Research Seminar, Lucca Italy., Jul 20, 2024 Invited
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Special lecture, 101th Annual Meeting of Physiological Society of Japan (Fukuoka, Japan)., Mar 28, 2024 Invited
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The Augustine Symposium (NTU, Singapore)., Dec 1, 2023 Invited
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Excitatory Synapses and Brain Function Gordon Research Conference (Les Diablerets, Switzerland)., Jun 6, 2023 Invited
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The Laboratory of Molecular Biology seminar series, Cambridge University (Cambridge, UK)., Jun 2, 2023 Invited
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IRCN- iPlasticity International Symposium, 2023.1.10-11 (Tokyo)., Jan 10, 2023 Invited
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“Neural Pathways Underlying Brain Function and Pathologies” Nature Virtual Conference (Zoom)., Jul 28, 2022 Invited
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JST-CREST "Opt Bio" / IIIS Joint Symposium (Sendai, Zoom)., Mar 14, 2022 Invited
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The International Symposium on Development and Plasticity of Neural Systems, WPI-ASHBi (Kyoto, Zoom)., Mar 14, 2022 Invited
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Science Salon of IRCN (Tokyo, Zoom)., Jan 6, 2021 Invited
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Ruth K. Broad Foundation Seminar, Duke University (Durham, USA), Feb 11, 2020 Invited
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Workshop on the dynamic brain(Jerusalem), Nov 28, 2019 Invited
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Japan UK Neuroscience Symposium (AMED), Feb 11, 2019 Invited
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Japanese Society of Neuroscience, Jul 29, 2018 Invited
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World Congress of Pharmacological Sciences, Jul 6, 2018 Invited
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Special Lecture, Japanese Society of Neuroscience, Jul 22, 2017 Invited
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Gordon Research Conference, Jun 1, 2017 Invited
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The Brain Conferences, Apr 24, 2017 Invited
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Special Lecture, Society for Neuroscience, Nov 13, 2016 Invited
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Cold Spring Harbor Asia Conference, May 19, 2016 Invited
Research Projects
28-
戦略的な研究開発の推進 戦略的創造研究推進事業 CREST, 科学技術振興機構, 2021 - 2026
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Aug, 2020 - Mar, 2024
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2021
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科学研究費補助金(基盤研究S), 文部科学省, May, 2014 - Mar, 2019
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2012 - Mar, 2017
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Specially Promoted Research, Japan Society for the Promotion of Science, 2009 - 2014
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科学研究費補助金(特別推進研究), 文部科学省, 2009 - 2013
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科学研究費助成事業, 基盤研究(A), 日本学術振興会, 2009 - 2009
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Specially Promoted Research, Japan Society for the Promotion of Science, 2004 - 2008
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科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2003 - 2004
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科学研究費補助金(基盤研究(S)), 基盤研究(S), 文部科学省, 2003 - 2004
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2000 - 2004
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科学研究費助成事業, 特定領域研究, 日本学術振興会, 2003 - 2003
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科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2002 - 2002
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2000 - 2002
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科学研究費補助金(特定領域研究(C)), 特定領域研究(C), 文部科学省, 2000 - 2000
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 1995 - 1999
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科学研究費補助金(基盤研究(C)), 基盤研究(C), 文部科学省, 1998 - 1998
Misc.
85-
Annual Review神経, 2016 7-13, 2016
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実験医学, 34 587-590, 2016
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分子精神医学, 15(1) 30-37, Jan, 2015
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65(1) 7-11, Jan, 2014
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Brain and Nerve, 66(8) 987-993, 2014
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応用物理学会春季学術講演会講演予稿集(CD-ROM), 60th ROMBUNNO.27P-G17-4, Mar 11, 2013
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2013 Peer-reviewedInvited
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日本解剖学会総会・全国学術集会講演プログラム・抄録集, 118th 178, 2013
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70 99-103, May, 2012
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Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 189-191, Jan 1, 2012
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15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 1 449-451, Dec 1, 2011
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66(10) 2336-2341, Oct, 2011
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電気学会研究会資料. BMS, バイオ・マイクロシステム研究会 = The papers of Technical Meeting on Bio Micro Systems, IEE Japan, 2011(1) 29-34, Mar 22, 2011
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NEUROSCIENCE RESEARCH, 71 E412-E412, 2011
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NEUROSCIENCE RESEARCH, 71 E206-E206, 2011
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NEUROSCIENCE RESEARCH, 71 E312-E312, 2011
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14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, 3 2111-2113, Dec 1, 2010
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61(3) 222-226, May, 2010
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科学, 80(3) 232-241, Mar, 2010
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NEUROSCIENCE RESEARCH, 68 E340-E340, 2010