論文

査読有り 国際誌
2019年3月4日

Acquisition of Quasi-Monochromatic Dual-Energy in a Microfocus X-ray Generator and Development of Applied Technology.

Diagnostics
  • Hiroaki Hasegawa
  • ,
  • Masanori Sato

担当区分
筆頭著者
9
1
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/diagnostics9010027

In regenerative medicine, evaluation of bone mineral density using a microfocus X-ray generator could eventually be used to determine the degree of bone tissue regeneration. To evaluate bone mineral density against regenerated bone material, two low-energy X-rays are necessary. Herein, the acquisition of quasi-monochromatic, dual-energy soft X-ray and the subsequent medical application were examined using the K-absorption edges of two types of metal filters (i.e., zirconium and tin) in a microfocus X-ray generator. Investigation of the optimal tube voltage and filter thickness to form a quasi-monochromatic energy spectrum with a single filter revealed that a filter thickness of 0.3 mm results in an optimal monochromatization state. When a dual filter was used, the required filter thickness was 0.3 mm for tin and 0.2 mm for zirconium at a tube voltage of 35 kV. For the medical application, we measured quasi-monochromatic, dual-energy X-rays to evaluate the measurement accuracy of bone mineral density. Using aluminum as a simulated bone sample, a relative error of ≤5% was consistent within the aluminum thickness range of 1⁻3 mm. These data suggest that a bone mineral density indicator of recycled bone material can be easily obtained with the quasi-monochromatic X-ray technique using a microfocus X-ray generator.

リンク情報
DOI
https://doi.org/10.3390/diagnostics9010027
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30836635
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468472

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