晴希生ハッサン (HASSAN Hakimi) - マイポータル

基本情報

所属: 帯広畜産大学原虫病研究センター特任研究員

J-GLOBAL ID: 201901011591348873
researchmap会員ID: B000380997

外部リンク: http://www.tm.nagasaki-u.ac.jp/protozoology/eng/

A parasitologist with research interest on finding and characterizing the genes responsible for the virulence of hemoparasites such as Babesia spp. with aiming to find novel drug and vaccine targets.

研究キーワード

研究分野

ライフサイエンス / 寄生虫学 / Molecular parasitology

経歴

2019年11月 - 現在

Institute of Trpical Medicine (NEKKKEN), Nagasaki University Assistant Professor
2018年4月 - 2019年10月

Institute of Tropical Medicine (NEKKEN), Nagasaki University Postdoc
2016年4月 - 2018年3月

Institute of Tropical Medicine (NEKKEN), Nagasaki University JSPS postdoc
2014年4月 - 2016年3月

Institute of Tropical Medicine (NEKKEN), Nagasaki University Postdoc
2013年10月 - 2014年3月

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine Researcher

学歴

2009年10月 - 2013年9月

United Graduate School of Veterinary Sciences, Gifu University Doctor of Veterinary Science
2008年4月 - 2009年9月

Obihiro University of Agriculture and Veterinary medicine Master of Animal and Food Hygiene
1999年10月 - 2005年9月

Faculty of Veterinary Medicine, Tehran University Doctor of Veterinary Medicine (DVM)

受賞

2018年8月

Travel Award to attend ICOPA 2018 Japanese Society of Parasitology

晴希生ハッサン
2014年1月

Award of Excelence National Research Center for Protozoan Diseases, Laboratory of Advanced Preventive Medicine

晴希生ハッサン
2012年12月

Best student presentation award Joint International Tropical Medicine Meeting 2012 (JITMM2012)

晴希生ハッサン
2007年4月

Postgraduate Scholarship Japanese government scholarship (Monbusho)

晴希生ハッサン
2005年9月

Honor graduate, Doctor of Veterinary Medicine Tehran University

晴希生ハッサン

論文

Advances in understanding red blood cell modifications by Babesia.

Hassan Hakimi, Junya Yamagishi, Shin-Ichiro Kawazu, Masahito Asada

PLoS pathogens 18(9) e1010770 2022年9月
Isolation of viable Babesia bovis merozoites to study parasite invasion

Hassan Hakimi, Masahito Asada, Takahiro Ishizaki, Shinichiro Kawazu

Scientific Reports 11(1) 2021年12月
Recent Advances in Molecular Genetic Tools for Babesia.

Hassan Hakimi, Masahito Asada, Shin-Ichiro Kawazu

Veterinary sciences 8(10) 2021年10月8日
Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Nattawat Chaiyawong, Takahiro Ishizaki, Hassan Hakimi, Masahito Asada, Kazuhide Yahata, Osamu Kaneko

Parasitology International 102479-102479 2021年10月
cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii

Takahiro Ishizaki, Masahito Asada, Hassan Hakimi, Nattawat Chaiyawong, Yuto Kegawa, Kazuhide Yahata, Osamu Kaneko

Parasitology International 102435-102435 2021年8月
Glycosphingolipid GM3 is localized in both exoplasmic and cytoplasmic leaflets of Plasmodium falciparum malaria parasite plasma membrane.

Shiomi Koudatsu, Tatsunori Masatani, Rikako Konishi, Masahito Asada, Hassan Hakimi, Yuna Kurokawa, Kanna Tomioku, Osamu Kaneko, Akikazu Fujita

Scientific reports 11(1) 14890-14890 2021年7月21日
Novel Babesia bovis exported proteins that modify properties of infected red blood cells

Hassan Hakimi, Thomas J. Templeton, Miako Sakaguchi, Junya Yamagishi, Shinya Miyazaki, Kazuhide Yahata, Takayuki Uchihashi, Shin-ichiro Kawazu, Osamu Kaneko, Masahito Asada

PLOS Pathogens 16(10) e1008917-e1008917 2020年10月5日
A novel Plasmodium yoelii pseudokinase, PypPK1, is involved in erythrocyte invasion and exflagellation center formation.

Takahiro Ishizaki, Nattawat Chaiyawong, Hassan Hakimi, Masahito Asada, Mayumi Tachibana, Tomoko Ishino, Kazuhide Yahata, Osamu Kaneko

Parasitology international 76 102056-102056 2020年6月査読有り
Transient transfection of Babesia ovis using heterologous promoters.

Rosa C, Asada M, Hakimi H, Domingos A, Pimentel M, Antunes S

Ticks and tick-borne diseases 10(6) 101279 2019年10月査読有り
Initiated Babesia ovata Sexual Stages under In Vitro Conditions Were Recognized by Anti-CCp2 Antibodies, Showing Changes in the DNA Content by Imaging Flow Cytometry.

Thu-Thuy Nguyen, Minh-Anh Dang-Trinh, Luna Higuchi, Juan Mosqueda, Hassan Hakimi, Masahito Asada, Junya Yamagishi, Rika Umemiya-Shirafuji, Shin-Ichiro Kawazu

Pathogens (Basel, Switzerland) 8(3) 2019年7月17日
82

Epidemiology, risk factors, and co-infection of vector-borne pathogens in goats from Sistan and Baluchestan province, Iran

晴希生ハッサン

PLoS ONE 14(6)(e0218609) 2019年査読有り
133

Genome editing of Babesia bovis using CRISPR/Cas9 system

晴希生ハッサン

mSphere 4(3)(e00109-19) 2019年査読有り
The application of the HyPer fluorescent sensor in the real-time detection of H2O2 in Babesia bovis merozoites in vitro

Masahito Asada, Hassan Hakimi, Shin-ichiro Kawazu

Veterinary Parasitology 255 78-82 2018年5月15日査読有り
Author Correction: Genetic homogeneity of goat malaria parasites in Asia and Africa suggests their expansion with domestic goat host.

Morakot Kaewthamasorn, Mika Takeda, Tawee Saiwichai, Jesse N Gitaka, Sonthaya Tiawsirisup, Yuhei Imasato, Ehab Mossaad, Ali Sarani, Winai Kaewlamun, Manun Channumsin, Suchart Chaiworakul, Wichit Katepongpun, Surapong Teeveerapunya, Jarus Panthong, Dominic K Mureithi, Saw Bawm, Lat Lat Htun, Mar Mar Win, Ahmed Ali Ismail, Abdalla Mohamed Ibrahim, Keisuke Suganuma, Hassan Hakimi, Ryo Nakao, Ken Katakura, Masahito Asada, Osamu Kaneko

Scientific reports 8(1) 7641-7641 2018年5月11日査読有り
Establishment of a stable transfection system for genetic manipulation of Babesia gibsoni

Mingming Liu, Paul Franck Adjou Moumouni, Masahito Asada, Hassan Hakimi, Tatsunori Masatani, Patrick Vudriko, Seung-Hun Lee, Shin-Ichiro Kawazu, Junya Yamagishi, Xuenan Xuan

Parasites and Vectors 11(1) 2018年4月23日査読有り
Genetic homogeneity of goat malaria parasites in Asia and Africa suggests their expansion with domestic goat host

Kaewthamasorn Morakot, Takeda Mika, Saiwichai Tawee, Gitaka Jesse N, Tiawsirisup Sonthaya, Imasato Yuhei, Mossaad Ehab, Sarani Ali, Kaewlamun Winai, Channumsin Manun, Chaiworakul Suchart, Katepongpun Wichit, Teeveerapunya Surapong, Panthong Jarus, Mureithi Dominic K, Bawm Saw, Htun Lat Lat, Win Mar Mar, Ismail Ahmed Ali, Ibrahim Abdalla Mohamed, Suganuma Keisuke, Hakimi Hassan, Nakao Ryo, Katakura Ken, Asada Masahito, Kaneko Osamu

SCIENTIFIC REPORTS 8(1) 5827-5827 2018年4月11日査読有り
Identification and characterization of interchangeable cross-species functional promoters between Babesia gibsoni and Babesia bovis.

Liu M, Adjou Moumouni PF, Cao S, Asada M, Wang G, Gao Y, Guo H, Li J, Vudriko P, Efstratiou A, Ringo AE, Lee SH, Hakimi H, Masatani T, Sunaga F, Kawazu SI, Yamagishi J, Jia L, Inoue N, Xuan X

Ticks and tick-borne diseases 2017年11月査読有り
Whole-genome assembly of Babesia ovata and comparative genomics between closely related pathogens

Junya Yamagishi, Masahito Asada, Hassan Hakimi, Takeshi Q. Tanaka, Chihiro Sugimoto, Shin-ichiro Kawazu

BMC GENOMICS 18(1) 832 2017年10月査読有り
Transient transfection of intraerythrocytic Babesia gibsoni using elongation factor-1 alpha promoter

Mingming Liu, Masahito Asada, Shinuo Cao, Paul Franck Adjou Moumouni, Patrick Vudriko, Artemis Efstratiou, Hassan Hakimi, Tatsunori Masatani, Fujiko Sunaga, Shin-ichiro Kawazu, Junya Yamagishi, Xuenan Xuan

MOLECULAR AND BIOCHEMICAL PARASITOLOGY 216 56-59 2017年9月査読有り
Identification and functional analysis of a novel mitochondria-localized 2-Cys peroxiredoxin, BbTPx-2, from Babesia bovis

Tatsunori Masatani, Masahito Asada, Hassan Hakimi, Kei Hayashi, Junya Yamagishi, Shin-ichiro Kawazu, Xuenan Xuan

PARASITOLOGY RESEARCH 115(8) 3139-3145 2016年8月査読有り

もっとみる

MISC

2種類のインビトロ培養条件下における大型ピロプラズマ原虫Babesia ovataの比較トランスクリプトーム解析

田中健, 山岸潤也, HASSAN Hakimi, 麻田正仁, 河津信一郎

日本獣医学会学術集会講演要旨集 158th 304-304 2015年8月30日
Babesia ovataの短時間かつ安定的な遺伝子導入系の確立(Establishment of transient and stable transfection system for Babesia ovata)

Hakimi Hassan, 山岸潤也, 外川裕人, 田中健, 金子修, 河津信一郎, 麻田正仁

日本獣医学会学術集会講演要旨集 158回 304-304 2015年8月
Water buffalo as sentinel animals for schistosomiasis surveillance

Jose Ma M. Angeles, Lydia R. Leonardo, Yasuyuki Goto, Masashi Kirinoki, Elena A. Villacorte, Hassan Hakimi, Kharleezelle J. Moendeg, Seungyeon Lee, Pilarita T. Rivera, Noboru Inoue, Yuichi Chigusa, Shin-ichiro Kawazu

BULLETIN OF THE WORLD HEALTH ORGANIZATION 93(7) 511-512 2015年7月
WR99210選択システム及びブラスチシジンS選択システムの併用によるBabesia bovis遺伝子改変技術の確立及びノックアウト遺伝子相補実験への応用

麻田正仁, 矢幡一英, HAKIMI Hassan, 横山直明, 五十嵐郁男, 金子修, SUAREZ Carlos, 河津信一郎

日本寄生虫学会大会プログラム・抄録集 84th 72 2015年2月
Babesia bovisにおけるダブルトランスフェクション法の確立

麻田正仁, CARLOS Suarez, HASSAN Hakimi, 横山直明, 五十嵐郁男, 矢幡一英, 金子修, 河津信一郎

日本獣医学会学術集会講演要旨集 157th 361 2014年8月11日
人畜共通住血吸虫症サーベイランスの監視動物としての水牛(Water buffaloes as sentinel animal population for zoonotic schistosomiasis surveillance)

Angeles Jose Ma, Leonardo Lydia, 後藤康之, 桐木雅史, Villacorte Elena, Hakimi Hassan, Moendeg Kharleezelle, Lee Seungyeon, Rivera Pilarita, 井上昇, 千草雄一, 河津信一郎

日本獣医学会学術集会講演要旨集 157回 366-366 2014年8月
熱帯熱マラリア原虫 1-Cysペルオキシレドキシンに対するモノクローナル抗体の作製とマラリア診断における応用可能性(Development of monoclonal antibodies against Plasmodium falciparum 1-Cys peroxiredoxin and its possible application for malaria diagnosis)

Hakimi Hassan, Nguyen Thu-Thuy, 菅沼啓輔, 増田裕乃, Angeles Jose Ma. M, 井上昇, 河津信一郎

日本獣医学会学術集会講演要旨集 155回 216-216 2013年3月

講演・口頭発表等

A novel Babesia bovis secreted protein responsible for binding of infected erythrocyte to endothelial cells

晴希生ハッサン

The 30th Annual Molecular Parasitology Meeting. 2019年9月15日
Proteomics approach leads to the identification of novel Babesia bovis proteins expressed on the surface of infected erythrocytes

晴希生ハッサン

The 88th Annual Meeting of the Japanese Society of Parasitology 2019年3月15日
Proteomics approach leads to the identification of novel Babesia bovis proteins expressed on the surface of infected erythrocytes

晴希生ハッサン

The 14th International Congress of Parasitology (ICOPA 2018) 2018年8月19日

所属学協会

共同研究・競争的資金等の研究課題

Functional characterization of Babesia bovis proteins expressed on the surface of infected erythrocytes- Toward identification of novel vaccine and therapeutic candidates

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) 2019年4月 - 2021年3月

晴希生ハッサン
脳性バベシア症における原虫感染赤血球接着機構の解明

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) 2015年4月 - 2016年3月

晴希生ハッサン
Evaluation of the biological functions of 1-Cys peroxiredoxin by disruption of the gene in Plasmodium falciparum

United Graduate School of Veterinary Science (UGSVS) Gifu University Grant-in-Aid (Graduate Students Activation Expense) 2012年4月 - 2013年3月

晴希生ハッサン