講演・口頭発表等

2020年

老化促進モデルマウスSAMP8の行動異常に対するアントシアニン高含有カシス抽出物の効果

日本薬理学会年会要旨集
  • 島田 美理
  • ,
  • 前多 隼人
  • ,
  • 七島 直樹
  • ,
  • 山田 清文
  • ,
  • 中島 晶

開催年月日
2020年 - 2020年
記述言語
日本語
会議種別
主催者
公益社団法人 日本薬理学会

<p>Anthocyanins possess high antioxidant activity and are the major group of polyphenols in blackcurrant, a regional specialty in Aomori prefecture. In this study, we investigated the effect of black currant extracts on cognitive and emotional abnormalities in the senescence-accelerated mouse prone 8 (SAMP8). Four month-old SAMP8 mice were fed a basal diet supplemented with 3% blackcurrant extracts for 2 months, and then behavioral experiments were conducted. In the novel object recognition test, treatment with blackcurrant extracts improved the memory impairment in SAMP8 mice. In addition, reduced anxiety-like behavior in SAMP8 mice was reversed by the extracts in the elevated plus maze test. These results suggest that supplementation of blackcurrant extracts has the potential to improve cognitive and emotional abnormalities in aging as well as age-related neurodegenerative diseases such as Alzheimer's disease.</p>

リンク情報
DOI
https://doi.org/10.1254/jpssuppl.93.0_1-SS-21