論文

査読有り 国際誌
2021年

Blackcurrant (Ribes nigrum l.) extract exerts potential vasculoprotective effects in ovariectomized rats, including prevention of elastin degradation and pathological vascular remodeling

Nutrients
  • Horie, K.
  • ,
  • Nanashima, N.
  • ,
  • Maeda, H.
  • ,
  • Tomisawa, T.
  • ,
  • Oey, I.

13
2
開始ページ
560
終了ページ
560
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/nu13020560
出版者・発行元
{MDPI} {AG}

Estrogen exerts cardioprotective effects in menopausal women. Phytoestrogens are plant-derived substances exhibiting estrogenic activity that could beneficially affect vascular health. We previously demonstrated that blackcurrant (Ribes nigrum L.) extract (BCE) treatment exerted beneficial effects on vascular health via phytoestrogenic activity in ovariectomized (OVX) rats, which are widely used as menopausal animal models. Here, we examined whether BCE treatment reduced elastin degradation and prevented pathological vascular remodeling in OVX rats fed a regular diet (OVX Control) or a 3% BCE-supplemented diet (OVX BCE), compared with sham surgery rats fed a regular diet (Sham) for 3 months. The results indicated a lower staining intensity of elastic fibers, greater elastin fragmentation, and higher α-smooth muscle actin protein expression in OVX Control rats than in OVX BCE and Sham rats. Pathological vascular remodeling was only observed in OVX Control rats. Additionally, we investigated matrix metalloproteinase (MMP)-12 mRNA expression levels to elucidate the mechanism underlying elastin degradation, revealing significantly upregulated MMP-12 mRNA expression in OVX Control rats compared with that in Sham and OVX BCE rats. Together, we identify BCE as exerting a vascular protective effect through reduced MMP-12 expression and vascular smooth muscle cell proliferation. To our knowledge, this is the first report indicating that BCE might protect against elastin degradation and pathological vascular remodeling during menopause.

リンク情報
DOI
https://doi.org/10.3390/nu13020560
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33567796
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915542
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85100526268&partnerID=MN8TOARS
ID情報
  • DOI : 10.3390/nu13020560
  • ISSN : 2072-6643
  • ORCIDのPut Code : 95211527
  • PubMed ID : 33567796
  • PubMed Central 記事ID : PMC7915542
  • SCOPUS ID : 85100526268

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