2015年4月
Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells
FEBS LETTERS
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- 巻
- 589
- 号
- 10
- 開始ページ
- 1112
- 終了ページ
- 1118
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.febslet.2015.03.022
- 出版者・発行元
- ELSEVIER SCIENCE BV
Hepatitis B virus (HBV) replication is controlled by liver-enriched transcriptional factors, including forkhead box protein A (FOXA) members. Here, we found that FOXA members are directly and indirectly involved in HBV replication in human hepatic cells. HBV replication was elevated in HuH-7 treated with individual FOXA members-specific siRNA. Reciprocally, the downregulation of HBV replication was observed in FOXA-induced HuH-7. However, the mechanism of downregulation is different among FOXA members at the level of HBV RNA transcription, such as precore/pg RNA and 2.1 kb RNA. In addition, FOXA1 and FOXA2 suppressed nuclear hormone receptors, such as HNF4 alpha, that are related to HBV replication. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.febslet.2015.03.022
- ISSN : 0014-5793
- eISSN : 1873-3468
- PubMed ID : 25836733
- Web of Science ID : WOS:000353197500009