2017年12月
Identification of novel bone morphogenetic protein- responsive elements in a hepcidin promoter.
FEBS letters
- ,
- ,
- ,
- 巻
- 591
- 号
- 23
- 開始ページ
- 3895
- 終了ページ
- 3905
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/1873-3468.12900
Hepcidin plays a central role in systemic iron metabolism. The bone morphogenetic protein (BMP) pathway regulates expression of hepcidin through transcriptional activation via BMP-responsive elements (REs) 1 and 2 on the promoter. Previous studies also revealed that the BMP pathway stimulates transcription of its target genes via GC-rich sequences on the promoter. A search for GC-rich sequences on the hepcidin promoter indicated 13 regions across the distal (A to F), middle (G to I), and proximal (J to M) areas; among them, mutations of the GC-rich element found in regions B to D exhibited decreased responsiveness to ALK3(QD) expression in the presence of BMP-RE1 mutations, indicating necessity of the elements for full expression of hepcidin by the BMP pathway.
- ID情報
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- DOI : 10.1002/1873-3468.12900
- ISSN : 0014-5793
- PubMed ID : 29105755