東元 祐一郎

Claudin-2 extracellular loop 1-mimetic peptides functionally inhibit combined hepatocellular-cholangiocarcinoma cells. 

Scientific reports 2026年7月1日  査読有り

Sulforaphane inhibits cardiac fibrosis induced by advanced glycation end product-receptor axis through its anti-oxidative property. 

Acta diabetologica 2025年8月11日  査読有り

Heme Regulatory Motif of Heme Oxygenase-2 Is Involved in the Interaction with NADPH–Cytochrome P450 Reductase and Regulates Enzymatic Activity 

International Journal of Molecular Sciences 26(5) 2025年3月  査読有り

Involvement of Mineralocorticoid Receptor Activation by High Mobility Group Box 1 and Receptor for Advanced Glycation End Products in the Development of Acute Kidney Injury. 

Kidney360 6(2) 208-218 2025年2月1日  査読有り

Serum Levels of the C-terminal Fragment of Fibroblast Growth Factor 23 (C-FGF23) and Hepcidin in Patients with Hemodialysis Undergoing Treatment with a Proline Hydroxylase Domain (PHD) Inhibitor 

Journal of Clinical Nephrology 8(3) 132-137 2024年10月14日  最終著者責任著者

DNA Aptamer Raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing Receptors for Advanced Glycation End Product-Induced Oxidative Stress and Inflammation in the Testes of Diabetic Mice 

International Journal of Molecular Sciences 25(11) 5947-5947 2024年5月29日  査読有り

Clinical Usefulness of the serum-Soluble Transferrin Receptor in Iron Dysregulation Associated with long-Term Hemodialysis 

International Journal of Clinical Case Reports and Reviews 17(02) 01-07 2024年4月30日  査読有り最終著者責任著者

Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice 

Biomedicines 11(12) 3112-3112 2023年11月22日  査読有り

Circulating Levels of Fibroblast Growth Factor 23 Selective for C-Terminal (FGF23-CT) in Hemodialysis Patients 

Journal of Clinical Nephrology 7(3) 085-091 2023年10月13日  査読有り

SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis 

International Journal of Molecular Sciences 24(7) 6505-6505 2023年3月30日  査読有り

Heparin and β2-microglobulin amyloidogenesis 

GSC Biological and Pharmaceutical Sciences 22(2) 070-078 2023年2月28日  査読有り筆頭著者責任著者

Serum Intact and Total Fibroblast Growth Factor 23 Levels and Iron-related Parameters in Hemodialysis Patients 

Journal of Clinical and Medical Research 4(5) 1-18 2022年10月29日  査読有り

The Therapeutic Potential of DNA Aptamer for Dialysis-Related Amyloidosis 

International Journal of Clinical Nephrology 4(2) 1-5 2022年9月29日  査読有り筆頭著者責任著者

DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice 

Oxidative Medicine and Cellular Longevity 2021 1-20 2021年8月7日  査読有り

Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1 

Biochemistry 60(29) 2300-2308 2021年7月27日  査読有り

Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats 

Journal of Cardiology 78(1) 12-16 2021年7月  査読有り

DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice 

Diabetes and Vascular Disease Research 18(1) 147916412199053-147916412199053 2021年1月  査読有り

Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease 

Scientific Reports 10(1) 17647-17659 2020年12月  査読有り

Erythropoiesis stimulating agents are associated with serum fibroblast growth factor 23 metabolism in patients on hemodialysis 

Clinical Kidney Journal 14(3) 1-7 2020年6月23日  査読有り最終著者責任著者

Heparin and Amyloid β2-Microglobulin 

International Journal of Clinical Case Reports and Reviews 2(2) 01-04 2020年5月5日  査読有り最終著者責任著者

Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction 

International Journal of Molecular Sciences 2020年4月  査読有り

Fructose causes endothelial cell damage via activation of advanced glycation end products-receptor system. 

Diabetes & vascular disease research 16(6) 556-561 2019年11月  査読有り

Long-Term Local Injection of RAGE-Aptamer Suppresses the Growth of Malignant Melanoma in Nude Mice. 

Journal of oncology 2019 7387601-7387601 2019年  査読有り

RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice 

Scientific Reports 8(1) 2686 2018年12月1日  査読有り

Advanced glycation end products evoke inflammatory reactions in proximal tubular cells via autocrine production of dipeptidyl peptidase-4. 

Microvascular research 120 90-93 2018年7月  査読有り

Selection of DNA Aptamer That Blocks the Fibrillogenesis of a Proteolytic Amyloidogenic Fragment of β₂ m. 

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 22(1) 61-66 2018年2月1日  査読有り責任著者

Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension. 

PloS one 13(9) e0203046 2018年  査読有り

Methylglyoxal-derived hydroimidazolone-1 evokes inflammatory reactions in endothelial cells via an interaction with receptor for advanced glycation end products 

DIABETES & VASCULAR DISEASE RESEARCH 14(5) 450-453 2017年9月  査読有り

Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor 

JOURNAL OF BIOCHEMISTRY 162(2) 113-122 2017年8月  査読有り

RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy 

DIABETES 66(6) 1683-1695 2017年6月  査読有り

N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties 

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 17(1) 137 2017年3月  査読有り

Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System 

CURRENT PHARMACEUTICAL DESIGN 23(8) 1135-1141 2017年  査読有り最終著者

RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice 

MOLECULAR MEDICINE 23 295-306 2017年  査読有り

Influence of heparin molecular size on the induction of C- terminal unfolding in β2-microglobulin. 

Molecular biology research communications 5(4) 225-232 2016年12月  査読有り責任著者

Protective Role of PEDF-Derived Synthetic Peptide Against Experimental Diabetic Nephropathy 

HORMONE AND METABOLIC RESEARCH 48(9) 613-619 2016年9月  

Peptide Deformylase Processable Triazole-containing Formyl Peptide Mimetics 

2016年3月  査読有り

AGE aptamer inhibits neointimal hyperplasia in balloon-injured rat carotid arteries 

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S246 2016年3月  査読有り筆頭著者責任著者

Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples 

ANALYTICAL BIOCHEMISTRY 489 50-52 2015年11月  査読有り

Development of a monoclonal antibody-based ELISA system for glyceraldehyde-derived advanced glycation end products 

IMMUNOLOGY LETTERS 167(2) 141-146 2015年10月  査読有り

Pigment epithelium-derived factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate cancer cells 

ONCOLOGY LETTERS 10(4) 2644-2648 2015年10月  査読有り

DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice 

JOURNAL OF PHARMACOLOGICAL SCIENCES 128(3) S218 2015年7月  査読有り筆頭著者責任著者

RAGE-DNA APTAMER IMPROVES ALDOSTERON-INDUCED RENAL INJURY POSSIBLY VIA INHIBITION OF RAC1-MR AXIS IN MICE WITH HYPERTENSIVE NEPHROPATHY 

NEPHROLOGY DIALYSIS TRANSPLANTATION 30 2015年5月  査読有り

DNA Aptamer Raised Against Advanced Glycation End Products (AGEs) Improves Glycemic Control and Decreases Adipocyte Size in Fructose-Fed Rats by Suppressing AGE-RAGE Axis 

HORMONE AND METABOLIC RESEARCH 47(4) 253-258 2015年4月  

C-terminal unfolding of an amyloidogenic β2-microglobulin fragment: ΔN6β2-microglobulin. 

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 22(1) 54-60 2015年3月  査読有り

Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE 

CARDIOVASCULAR DIABETOLOGY 14 1 2015年1月  査読有り

DNA Aptamer Raised against Advanced Glycation End Products Prevents Abnormalities in Electroretinograms of Experimental Diabetic Retinopathy 

OPHTHALMIC RESEARCH 54(4) 175-180 2015年  査読有り

Evaluation of in vitro properties of predicted kinases that phosphorylate serine residues within nuclear localization signal 1 of high mobility group box 1. 

Journal of peptide science : an official publication of the European Peptide Society 20(8) 613-617 2014年8月  査読有り最終著者

Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor 

Journal of Biochemistry 155(6) 353-360 2014年6月  査読有り最終著者

DNA-APTAMER RAISED AGAINST RAGE BLOCKS THE PROGRESSION OF EXPERIMENTAL DIABETIC NEPHROPATHY 

NEPHROLOGY 19 89-89 2014年5月  査読有り

DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice 

LABORATORY INVESTIGATION 94(4) 422-429 2014年4月  査読有り