Hirofumi Hanaoka

Profile Information

Affiliation: 研究所教授, 関西医科大学

Degree: 医学博士(群馬大学)

J-GLOBAL ID: 201801015820599760
researchmap Member ID: B000336301

Research Interests

Research Areas

Research History

Apr, 2022 - Present

Near InfraRed Photo-Immuno Research Institute at Kansai Medical University, Kansai Medical University
Jul, 2020 - Present

客員教授, 群馬大学大学院医学系研究科
Jul, 2020 - Mar, 2022

Kansai Medical University
Aug, 2014 - Jun, 2020

Graduate School of Medicine, Gunma University
Mar, 2011 - Jul, 2014

Graduate School of Pharmaceutical Sciences, Chiba University
Aug, 2003 - Feb, 2011

Graduate School of Medicine, Gunma University

Education

Apr, 2001 - Jul, 2003

Graduate School of Pharmaceutical Sciences, Kyoto University
Apr, 1999 - Mar, 2001

Graduate School of Pharmaceutical Sciences, Kyoto University
Apr, 1995 - Mar, 1999

Faculty of Pharmaceutical Sciences, Kyoto University

Awards

Nov, 2015

第12回日本核医学会研究奨励賞最優秀賞受賞, 日本核医学会

花岡宏史

Papers

115

Comparative evaluation of radionuclide therapy using 90Y and 177Lu.

Hirofumi Hanaoka, Kazuyuki Hashimoto, Satoshi Watanabe, Shojiro Matsumoto, Tetsuya Sakashita, Shigeki Watanabe, Noriko S Ishioka, Keigo Endo

Annals of nuclear medicine, 37(1) 52-59, Jan, 2023
Enhancing the accumulation level of 3-[18F]fluoro-L-α-methyltyrosine in tumors by preloading probenecid

Ayaka Kanai, Hirofumi Hanaoka, Aiko Yamaguchi, Isa Mahendra, Citra Palangka, Yasuhiro Ohshima, Tetsuya Higuchi, Yoshito Tsushima

Nuclear Medicine and Biology, 104-105 47-52, Jan, 2022
Reduced Fatty Acid Use from CD36 Deficiency Deteriorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice.

Yogi Umbarawan, Ryo Kawakami, Mas Rizky A A Syamsunarno, Hideru Obinata, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Noriyo Hayakawa, Norimichi Koitabashi, Hiroaki Sunaga …

Metabolites, 11(12), Dec 17, 2021
Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy.

Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi …

EJNMMI physics, 8(1) 80-80, Dec 11, 2021
The Role of Ferrous Ion in the Effect of the Gadolinium-Based Contrast Agents (GBCA) on the Purkinje Cells Arborization: An In Vitro Study.

Achmad Adhipatria Perayabangsa Kartamihardja, Winda Ariyani, Hirofumi Hanaoka, Ayako Taketomi-Takahashi, Noriyuki Koibuchi, Yoshito Tsushima

Diagnostics (Basel, Switzerland), 11(12), Dec 8, 2021
64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity.

Ankita Nachankar, Takahiro Oike, Hirofumi Hanaoka, Ayaka Kanai, Hiro Sato, Yukari Yoshida, Hideru Obinata, Makoto Sakai, Naoto Osu, Yuka Hirota …

Cancers, 13(24), Dec 7, 2021
Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.

Ryo Kawakami, Miki Matsui, Ayumu Konno, Ryosuke Kaneko, Shreya Shrestha, Suman Shrestha, Hiroaki Sunaga, Hirofumi Hanaoka, Sawako Goto, Michihiro Hosojima …

The Journal of pathology, 255(4) 362-373, Dec, 2021
Enhancing the Therapeutic Effect of 2-211At-astato-α-methyl-L-phenylalanine with Probenecid Loading.

Hirofumi Hanaoka, Yasuhiro Ohshima, Hiroyuki Suzuki, Ichiro Sasaki, Tadashi Watabe, Kazuhiro Ooe, Shigeki Watanabe, Noriko S Ishioka

Cancers, 13(21), Nov 3, 2021
Potential of three-step pretargeting radioimmunotherapy using biotinylated bevacizumab and succinylated streptavidin in triple-negative breast cancer xenograft.

Wenchao Gu, Ryan Yudistiro, Hirofumi Hanaoka, Natsumi Katsumata, Yoshito Tsushima

Annals of nuclear medicine, 35(4) 514-522, Apr, 2021
Absorbed dose simulation of meta-211At-astato-benzylguanidine using pharmacokinetics of 131I-MIBG and a novel dose conversion method, RAP.

Tetsuya Sakashita, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi, Yoshito Tsushima …

Annals of nuclear medicine, 35(1) 121-131, Jan, 2021
Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy.

Yogi Umbarawan, Ryo Kawakami, Mas Rizky A A Syamsunarno, Norimichi Koitabashi, Hideru Obinata, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Noriyo Hayakawa, Hiroaki Sunaga …

Scientific reports, 10(1) 20809-20809, Nov 30, 2020
Renal Handling of 99mTc-Labeled Antibody Fab Fragments with a Linkage Cleavable by Enzymes on Brush Border Membrane.

Tomoya Uehara, Naoki Kanazawa, Chie Suzuki, Yuki Mizuno, Hiroyuki Suzuki, Hirofumi Hanaoka, Yasushi Arano

Bioconjugate chemistry, 31(11) 2618-2627, Oct 21, 2020
DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism.

Nozomi Furukawa, Norimichi Koitabashi, Hiroki Matsui, Hiroaki Sunaga, Yogi Umbarawan, Mas Rizky A A Syamsunarno, Aiko Yamaguchi, Masaru Obokata, Hirofumi Hanaoka, Tomoyuki Yokoyama …

Heart and vessels, 36(1) 136-146, Oct 18, 2020
Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model.

Yasuhiro Ohshima, Hiroyuki Suzuki, Hirofumi Hanaoka, Ichiro Sasaki, Shigeki Watanabe, Hiromitsu Haba, Yasushi Arano, Yoshito Tsushima, Noriko S Ishioka

Nuclear medicine and biology, 90-91 15-22, Aug 26, 2020
Selective synthesis of L-2-[18 F]fluoro-alpha-methylphenylalanine via copper-mediated 18 F-fluorination of (mesityl)(aryl)iodonium salt.

Aiko Yamaguchi, Hirofumi Hanaoka, Tetsuya Higuchi, Yoshito Tsushima

Journal of labelled compounds & radiopharmaceuticals, 63(8) 368-375, Jun 30, 2020
Diagnosis of bladder cancer using 18F-labeled α-methyl-phenylalanine tracers in a mouse model.

Isa Mahendra, Hirofumi Hanaoka, Aiko Yamaguchi, Tumenjargal Amartuvshin, Yoshito Tsushima

Annals of nuclear medicine, 34(5) 329-336, May, 2020
64Cu-ATSM and 99mTc(CO)3-DCM20 potential in the early detection of rheumatoid arthritis.

Trang Thuy Dam, Hirofumi Hanaoka, Takahito Nakajima, Aiko Yamaguchi, Koichi Okamura, Hirotaka Chikuda, Yoshito Tsushima

Modern rheumatology, 31(2) 1-7, Apr 23, 2020
Immuno-PET imaging for non-invasive assessment of cetuximab accumulation in non-small cell lung cancer.

Aiko Yamaguchi, Arifudin Achmad, Hirofumi Hanaoka, Yusri Dwi Heryanto, Anu Bhattarai, Ratianto, Erdene Khongorzul, Rini Shintawati, A Adhipatria P Kartamihardja, Ayaka Kanai …

BMC cancer, 19(1) 1000-1000, Oct 24, 2019 Peer-reviewed
Al¹⁸F-labeled alpha-melanocyte-stimulating hormone (α-MSH) peptide derivative for the early detection of melanoma.

Palangka CRAP, Hanaoka H, Yamaguchi A, Murakami T, Tsushima Y

Annals of nuclear medicine, 33(10) 733-739, Oct, 2019 Peer-reviewed
Novel ¹⁸F-Labeled α-Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging.

Hanaoka H, Ohshima Y, Yamaguchi A, Suzuki H, Ishioka NS, Higuchi T, Arano Y, Tsushima Y

Molecular pharmaceutics, 16(8) 3609-3616, Aug, 2019 Peer-reviewed

Misc.

RAP線量変換法の%ID/gの1回測定に関する基礎的検討

坂下哲哉, 松本翔二郎, 渡辺茂樹, 花岡宏史, 大島康宏, 生駒洋子, 右近直之, 東達也, 樋口徹也, 対馬義人 …

核医学(Web), 58(Supplement), 2021
Basic study of the RAP method as a patient-friendly dose evaluation for targeted alpha-nuclide therapy

坂下哲哉, 渡辺茂樹, 花岡宏史, 大島康宏, 生駒洋子, 右近直之, 佐々木一郎, 東達也, 樋口徹也, 対馬義人 …

アイソトープ・放射線研究発表会(Web), 58th, 2021
¹³¹I-MIBGの体内動態に着目した²¹¹At-MABGの線量評価シミュレーション

坂下哲哉, 渡辺茂樹, 花岡宏史, 大島康宏, 生駒洋子, 右近直之, 佐々木一郎, 東達也, 樋口徹也, 対馬義人 …

核医学(Web), 57(Supplement), 2020
Imaging Modalities for Evaluating Acute Therapeutic Effects after Photoimmunotherapy in Vivo

ZHANG Xieyi, YAMAGUCHI Aiko, NAKAJIMA Takahito, KARTAMIHARDJA Adhipatria, NGUYEN Thuhuong, OYUNBOLD Lamedocher, HANAOKA Hirofumi, TAKAHASHI Ayako, TSUSHIMA Yoshito

日本医学放射線学会総会抄録集, 76th, 2017
Development of therapeutic radiopharmaceuticals labeled with novel beta-emitting radionuclide

41(4) 197-202, Jul, 2016
MMP2を標的とした分子イメージングのための放射性代謝捕捉型プローブの開発に関する基礎的検討

米澤晶, 天滿敬, 近藤直哉, 佐野紘平, 花岡宏史, 小野正博, 佐治英郎

第63回日本薬学会近畿支部総会・大会, Sep, 2013
SPECT devices for small animals

Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System, 28(3) 236-238, Jul, 2013
Synthesis of radiohalogen-labeled peptides with high affinity to HER2/neu receptor

Ichiro Sasaki, Keiichi Yamada, Shigeki Watanabe, Hirofumi hanaoka, Yumi Sugo, Hiroyuki Oku, Noriko S. Ishioka

Peptide Science 2012, 2012 157-160, 2013
放射能量・放射線量の数値をどのようにみるか?

花岡宏史, 上原知也, 荒野泰

ぶんせき, (438) 310-314, Jun 5, 2011
生理活性ペプチドのイメージングを目指した芳香族アミノ酸誘導体の標識合成

津久井匠隆, 津久井匠隆, 渡辺茂樹, 山田圭一, 花岡宏史, 奥浩之, 松尾一郎, 遠藤啓吾, 石岡典子

アイソトープ・放射線研究発表会要旨集, 47th, 2010
核医学による分子イメージングの進歩 (特集分子イメージングの進歩)

花岡宏史, 織内昇

PET journal, (11) 16-18, 2010
Synthesis and evaluation of (76)BrDG for tumor diagnosis using microPET in mice

Y. Iida, N. Ishioka, S. Watanabe, H. Yoshioka, H. Hanaoka, S. Watanabe, T. Higuchi, N. Oriuchi, K. Endo

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 36 S353-S353, Sep, 2009
Nano- and Microsphere Encapsulation and Antigenic Properties of a Synthetic Peptide from Plasmodium falciparum

奥浩之, 矢野和彦, 花岡宏史, 長谷川伸, 山田圭一, 片貝良一, 飯田靖彦, 遠藤啓吾, 前川康成, 狩野繁之 …

日本化学会講演予稿集, 89th(2), 2009
Nano-particle materials prepared from a synthetic antigenic sequence of Plasmodium falciparum enolase.

H. Oku, K. Yamada, K. Kobayashi, R. Katakai, M. Ashfaq, H. Hanaoka, Y. Iida, K. Endo, S. Hasegawa, Y. Maekawa …

Peptide Science 2008, 2008 pp439-442., 2009
熱帯熱マラリア原虫由来の人工抗原を内包したナノ・マイクロ微粒子に関する研究

俵義宣, 奥浩之, 山田圭一, 花岡宏史, 遠藤啓吾, 狩野繁之, 鈴木守, 片貝良一

日本化学会講演予稿集, 88th(2), 2008
Synthesis and Properties of Novel Amphiphilic Block Copolymers Consisting of Metal Ion Coordinating Depsipeptides and Poly(ethylene glycol)

Ken-ichi Arai, Hiroyuki Oku, Keiichi Yamada, Hirofumi Hanaoka, Yasuhiro Iida, Keigo Endo, Kazuhiro Kohama, Ryoichi Katakai

Peptide Scienece 2007, 437-440, 2008
マトリックスメタロプロテアーゼ‐2を標的とするペプチド放射性薬剤の体内動態に関する検討

花岡宏史, 向高弘, 浅野大悟, 飯田靖彦, 遠藤啓吾, 佐治英郎

核医学, 44(3) 292-293, Oct 30, 2007
Development of Chemical Probes for the Chemokine Receptor CXCR4 Involving Radiolabeled T140 Analogs

TAMAMURA Hirokazu, HANAOKA Hirofumi, TSUTSUMI Hiroshi, OHASHI Nami, TANAKA Tomohiro, MORI Tomohiko, MUKAI Takahiro, DOI Ryuichiro, SAJI Hideo, FUJII Nobutaka

2006 254-254, Mar 1, 2007
3-ピリジルアラニンを配位子に持つ水溶性ペプチド錯体の合成的研究

奥浩之, 山田圭一, 花岡宏史

錯体化学討論会講演要旨集, 57th, 2007
Synthesis and Metal Ion Coordinating Properties of Amphiphilic Poly(peptide-block-ethyleneglycol).

Hiroyuki Oku, Keiichi Yamada, Ryoichi Katakai, Hirofumi Hanaoka, Yasuhiko Iida, Keigo Endo

Yakugaku Zasshi（薬学雑誌）, 127(Supplement Issue 2) pp. 79, 2007

Research Projects

光免疫療法を基盤とする革新的内視鏡治療の創出

戦略的な研究開発の推進創発的研究支援事業, 2021 - 2027

花岡宏史
Development of photoimmunotherapy that not require external light irradiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2024
At－211標識アミノ酸を用いた治療効果の高いα線治療法の創出

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

花岡宏史, 渡辺茂樹, 金井彩香, 渡部直史
64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Ohno Tatsuya
Development of an targeted radionuclide therapy of triple-negative breast cancer for clinical application

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Katsumata Natsumi
Development of self-assembling and tumor-specific ultrasound contrast agents using carbon nanotubes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Tsushima Yoshito
体内動態を制御したAt－211標識アミノ酸による汎用的α線治療法の創出

科研費基盤研究（B), Apr, 2018 - Mar, 2021

花岡宏史
Evaluation of Cu-64, Cu-67 Ions for Cancer Imaging and Therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

SUGO Yumi
Development of a radioimmunotherapy (RIT) agent for triple-negative breast cancer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Katsumata Natsumi
理論的な薬剤設計に基づくがん特異的Gd造影剤の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2016 - Mar, 2018

島田健裕, 花岡宏史
Development of a novel tumor-targeting ultrasound contrast agent and its application as a carrier for the drug delivery system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Tsushima Yoshito
Studies on PET Imaging of Cancer Using Cu-64 Ions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

SUGO Yumi, YAMAGUCHI Aiko, HANAOKA Hirofumi
A new approach using radioisotopes for peptide drug discovery

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

ISHIOKA NORIKO, HANAOKA Hirofumi, SASAKI Ichiro
新規薬剤設計に基づく高感度アポトーシスイメージング剤の開発

科研費基盤研究（C), Apr, 2014 - Mar, 2017

花岡宏史
Engineering radiolabeled antibody fragments for enhanced tumor to kidney ratio

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Uehara Tomoya, HANAOKA Hirofumi
Quantitative measurement of a new small animal SPECT/CT scanner with a semiconductor detector

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

KOBAYASHI Masato, KAWAI Keiichi, HANAOKA Hirofumi
がん診断用ＰＥＴ薬剤Ｂｒ－７６標識アミノ酸の開発と臨床への展開

科研費若手研究（A), Apr, 2010 - Mar, 2014

花岡宏史
RI標識後に抗体へ導入可能な新規キレート剤の開発と汎用的な標識抗体作製法の構築

科研費挑戦的萌芽研究, Apr, 2011 - Mar, 2013

花岡宏史
Basic investigation on radionuclide therapy with auger electron by using Br-77 labeled MBBG

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

WATANABE Shigeki, HANAOKA Hirofumi
99mTc-labeled probes imitating antibodies

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

ARANO Yasushi, UEHARA Tomoya, HANAOKA Hirofumi

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