Hideki Nakamura

Profile Information

Affiliation: Graduate School of Medicine, Hokkaido University

Degree: 医学博士(Jun, 2011, 北海道大学)

J-GLOBAL ID: 201301040965957050
researchmap Member ID: B000226219

External link

Research Interests

Research Areas

Life sciences / Dermatology /

Papers

Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes.

Hideyuki Kosumi, Mika Watanabe, Satoru Shinkuma, Takuma Nohara, Yu Fujimura, Tadasuke Tsukiyama, Giacomo Donati, Hiroaki Iwata, Hideki Nakamura, Hideyuki Ujiie …

The Journal of investigative dermatology, 142(6) 1576-1586, Jun, 2022
Cas9-guided haplotyping of three truncation variants in autosomal recessive disease.

Ken Natsuga, Yoshikazu Furuta, Shota Takashima, Takuma Nohara, Hsin-Yu Huang, Satoru Shinkuma, Hideki Nakamura, Yousuke Katsuda, Hideaki Higashi, Chao-Kai Hsu …

Human mutation, 43(7) 877-881, Apr 21, 2022
成人栄養障害型表皮水疱症患者を対象としたMuse細胞製品CL2020の国内1/2相試験 52週までの安全性の検討

藤田靖幸, 野原拓馬, 高島翔太, 夏賀健, 中村秀樹, 清水宏, 足立太起, 吉田憲司, 石河晃, 新熊悟 …

日本皮膚科学会雑誌, 132(3) 510-510, Mar, 2022
Hair follicle stem cell progeny heal blisters while pausing skin development

Yu Fujimura, Mika Watanabe, Kota Ohno, Yasuaki Kobayashi, Shota Takashima, Hideki Nakamura, Hideyuki Kosumi, Yunan Wang, Yosuke Mai, Andrea Lauria …

EMBO reports, 22(7), Jul 5, 2021
Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers.

Keisuke Imafuku, Mayumi Kamaguchi, Ken Natsuga, Hideki Nakamura, Hiroshi Shimizu, Hiroaki Iwata

Cell and tissue research, 384(3) 691-702, Jun, 2021
Intravenous allogeneic multilineage-differentiating stress-enduring cells in adults with dystrophic epidermolysis bullosa: a phase 1/2 open-label study.

Y Fujita, T Nohara, S Takashima, K Natsuga, M Adachi, K Yoshida, S Shinkuma, T Takeichi, H Nakamura, O Wada …

Journal of the European Academy of Dermatology and Venereology : JEADV, Mar 3, 2021
Cultured Epidermal Autografts from Clinically Revertant Skin as a Potential Wound Treatment for Recessive Dystrophic Epidermolysis Bullosa.

Matsumura W, Fujita Y, Shinkuma S, Suzuki S, Yokoshiki S, Goto H, Hayashi H, Ono K, Inoie M, Takashima S …

The Journal of investigative dermatology, 139(10) 2115-2124.e11, Oct, 2019 Peer-reviewed
Electron Microscopic and Immunohistochemical Findings of the Epidermal Basement Membrane in Two Families with Nail-patella Syndrome.

Shinkuma S, Nakamura H, Maehara M, Takashima S, Nomura T, Fujita Y, Hasegawa S, Sato-Matsumura KC, Abe R, Shimizu H

Acta dermato-venereologica, 99(12) 1110-1115, Sep, 2019 Peer-reviewed
Case of autoimmune intraepidermal and subepidermal blistering disease in which autoantibodies to desmoglein 1 and BP230 coexist.

Sugai T, Ujiie H, Nakamura H, Kikuchi K, Iwata H, Shimizu H

The Journal of dermatology, 46(6) e215-e216, Jun, 2019 Peer-reviewed
Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa using CRISPR/Cas9.

Takashima S, Shinkuma S, Fujita Y, Nomura T, Ujiie H, Natsuga K, Iwata H, Nakamura H, Vorobyev A, Abe R …

The Journal of investigative dermatology, 139(8) 1711-1721.e4, Mar, 2019 Peer-reviewed
Congenital nevi with hypomelanosis and fine scales.

Natsuga K, Oiso N, Kurokawa I, Tsubura A, Nakamura H, Maya Y, Nishie W, Kawada A, Shimizu H

European journal of dermatology : EJD, 29(1) 45-48, Feb, 2019 Peer-reviewed
Novel COL7A1 mutation in a family with bullous dermolysis of the newborn: Phenotypic variability associated with a COL7A1 mutation within the same family.

Shota Takashima, Satoru Shinkuma, Yasuyuki Fujita, Ken Natsuga, Toshifumi Nomura, Tokimasa Hida, Shuku Ishikawa, Hideki Nakamura, Riichiro Abe, Hiroshi Shimizu

The Journal of dermatology, 45(9) e260-e261-e261, Sep, 2018 Peer-reviewed
Ramucirumab-induced Multiple Haemangiomas of the Skin: Two Case Reports.

Kosumi H, Nishie W, Sugai T, Toyonaga E, Yoshimoto N, Nakamura H, Horibe R, Kitamura Y, Nakatsumi H, Shimizu H

Acta dermato-venereologica, 98(4) 454-455, Dec, 2017 Peer-reviewed
Superior Microvascular Perfusion of Infused Liposome-Encapsulated Hemoglobin Prior to Reductions in Infarctions after Transient Focal Cerebral Ischemia

Daisuke Shimbo, Takeo Abumiya, Kota Kurisu, Toshiya Osanai, Hideo Shichinohe, Naoki Nakayama, Ken Kazumata, Hideki Nakamura, Hiroshi Shimuzu, Kiyohiro Houkin

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 26(12) 2994-3003, Dec, 2017 Peer-reviewed
Loss of interaction between plectin and type XVII collagen results in epidermolysis bullosa simplex

Ken Natsuga, Wataru Nishie, Machiko Nishimura, Satoru Shinkuma, Mika Watanabe, Kentaro Izumi, Hideki Nakamura, Yoshiaki Hirako, Hiroshi Shimizu

HUMAN MUTATION, 38(12) 1666-1670, Dec, 2017 Peer-reviewed
A case of recessive dystrophic epidermolysis bullosa with a novel c.6885_6898de114 mutation in the COL7A1 gene

Satoru Shinkuma, Tae Masunaga, Saori Miyawaki, Shota Takashima, Ken Natsuga, Toshifumi Nomura, Yasuyuki Fujita, Hideki Nakamura, Hiroshi Shimizu

JOURNAL OF DERMATOLOGICAL SCIENCE, 88(1) 139-141, Oct, 2017 Peer-reviewed
Type XVII collagen coordinates proliferation in the interfollicular epidermis

Mika Watanabe, Ken Natsuga, Wataru Nishie, Yasuaki Kobayashi, Giacomo Donati, Shotaro Suzuki, Yu Fujimura, Tadasuke Tsukiyama, Hideyuki Ujiie, Satoru Shinkuma …

ELIFE, 6, Jul, 2017 Peer-reviewed
The first familial cases of epidermolysis bullosa simplex, generalized severe with p.Asn176Ser in KRT5 revealing the clinical chronology

T. Sugai, S. Shinkuma, K. Inafuku, S. Takashima, T. Nomura, Y. Fujita, H. Nakamura, H. Shimizu

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 31(5) e251-e253, May, 2017
Revertant Mosaicism in Ichthyosis with Confetti Caused by a Frameshift Mutation in KRT1

Shotaro Suzuki, Toshifumi Nomura, Toshinari Miyauchi, Masae Takeda, Hideki Nakamura, Satoru Shinkuma, Yasuyuki Fujita, Masashi Akiyama, Hiroshi Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(10) 2093-2095, Oct, 2016 Peer-reviewed
Transarterial Regional Brain Hypothermia Inhibits Acute Aquaporin-4 Surge and Sequential Microvascular Events in Ischemia/Reperfusion Injury

Kota Kurisu, Takeo Abumiya, Hideki Nakamura, Daisuke Shimbo, Hideo Shichinohe, Naoki Nakayama, Ken Kazumata, Hiroshi Shimizu, Kiyohiro Houkin

NEUROSURGERY, 79(1) 125-134, Jul, 2016 Peer-reviewed

Misc.

Two families of nail-patella syndrome with novel splice site mutations in the LMX1B gene

S. Shinkuma, H. Nakamura, S. Takashima, T. Nomura, Y. Fujita, S. Hasegawa, K. Matsumura, H. Shimizu, R. Abe

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(10) S231-S231, Oct, 2017
皮膚基底膜構築における17型コラーゲン細胞外領域切断の生理機能の解析

西村真智子, 西江渉, 新熊悟, 夏賀健, 中村秀樹, 清水宏, 白藤宜紀, 岩月啓氏, 澤村大輔

日本皮膚科学会雑誌, 127(9) 2111-2111, Aug, 2017
A case of recessive dystrophic epidermolysis bullosa with a novel c.6885_6898del14 mutation

S. Shinkukma, T. Masunaga, S. Miyawaki, S. Takashima, T. Nomura, Y. Fujita, H. Nakamura, H. Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(5) S87-S87, May, 2017
新規ケラチン1遺伝子変異によるichthyosis with confettiの1家系

鈴木翔多朗, 乃村俊史, 宮内俊成, 竹田真依, 中村秀樹, 新熊悟, 藤田靖幸, 清水宏, 秋山真志

角化症研究会記録集, 31 12-17, Mar, 2017
重症汎発型単純型表皮水疱症の家族例

須貝達朗, 新熊悟, 高島翔太, 乃村俊史, 藤田靖幸, 中村秀樹, 清水宏, 稲福和宏

日本皮膚科学会雑誌, 127(2) 221-221, Feb, 2017
Defective binding of plectin and collagen XVII leads to epidermolysis bullosa simplex

K. Natsuga, W. Nishie, M. Nishimura, S. Shinkuma, M. Watanabe, K. Izumi, H. Nakamura, Y. Hirako, H. Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(9) S186-S186, Sep, 2016
Keratinocyte death in severe cutaneous adverse drug reactions is mediated by necroptosis pathway of annexin A1/FPR1 interaction

N. Saito, T. Yanagi, S. Shinkuma, A. Suto, Y. Fujita, S. Suzuki, T. Nomura, H. Nakamura, H. Shimizu, R. Abe

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134 S3-S3, May, 2014
Loss of ELOVL1 enzyme causes lethal skin barrier disruption in mice

S. Suzuki, T. Nomura, T. Sassa, Y. Ohno, H. Nakamura, M. Akiyama, A. Kihara, H. Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134(4) 1177-1177, Apr, 2014
A CASE OF RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA WITH LONG-TERM FOLLOW-UP OF CULTURED EPIDERMAL AUTOGRAFT

Y. Fujita, S. Shinkuma, D. Sawamura, H. Kawasaki, H. Nakamura, M. Inoie, W. Nishie, H. Shimizu

WOUND REPAIR AND REGENERATION, 22(1) A18-A18, Jan, 2014
The mitochondrial fusion proteins Mfn1 and Mfn2 are involved in keratinization

A. Suto, R. Abe, N. Saito, S. Suzuki, Y. Fujita, T. Nomura, H. Nakamura, H. Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 S109-S109, May, 2013
A novel necroptosis pathway of annexin A1/FPR1 interaction in severe cutaneous adverse drug reactions

N. Saito, H. Qiao, T. Yanagi, S. Shinkuma, A. Suto, Y. Fujita, S. Suzuki, T. Nomura, H. Nakamura, H. Shimizu …

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 S28-S28, May, 2013
Bullous pemphigoid autoantibodies induce skin fragility in neonatal mice in a complement independent manner

T. Sasaoka, H. Ujiie, W. Nishie, A. Shibaki, H. Nakamura, H. Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 S29-S29, May, 2013
31-year follow-up of Kindler syndrome with severe intestinal involvement

S. Shimizu, W. Nishie, K. Tsuchiya, D. Inokuma, H. Koguchi, K. Kikuchi, S. Motoya, H. Nakamura, H. Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 S129-S129, May, 2013
Essential role of collagen XVII in basement membrane formation and keratinocyte migration

M. Nishimura, W. Nishie, Y. Shirafuji, S. Shinkuma, K. Natsuga, H. Nakamura, D. Sawamura, K. Iwatsuki, H. Shimizu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 S151-S151, May, 2013
アトピー性皮膚炎および先天性表皮水疱症として経過観察されていたKindler症候群の2例

神谷浩二, 白藤宜紀, 青山裕美, 岩月啓氏, 新熊悟, 夏賀健, 中村秀樹, 西江渉, 清水宏

日本皮膚科学会雑誌, 123(4) 456-456, Apr, 2013
ケラチン5のコイル1A領域N末端部にミスセンス変異を生じた単純型表皮水疱症

新熊悟, 西江渉, 夏賀健, 氏家英之, 中村秀樹, 清水宏, Jacyk Witold, 秋山真志

日本皮膚科学会雑誌, 123(4) 461-461, Apr, 2013
劣性栄養障害型表皮水疱症患者における遺伝子型-表現型の相互関係の解析

新熊悟, 西江渉, 夏賀健, 伊藤圭, 中村秀樹, 清水宏

日本皮膚科学会雑誌, 122(2) 381-381, Feb, 2012
【橋本公二コネクション-薬疹・水疱症・そして皮膚科医人生-】 (Part2)水疱症関連 (case 07)非Herlitz型接合部型表皮水疱症

松本圭子, 橋本公二, 薬師寺直喜, 西江渉, 夏賀健, 中村秀樹, 清水宏

Visual Dermatology, 11(2) 165-167, Jan, 2012
プレクチンの発現様式の違いによって2種類の表皮水疱症の臨床型が決定される

夏賀健, 西江渉, 秋山志, 新熊悟, 中村秀樹, 長崎暁理, 澤村大輔, 清水宏, Has Cristina, Bruckner-Tuderman Leena …

日本皮膚科学会雑誌, 122(1) 57-57, Jan, 2012
Distinctive anchoring fibril structures produced by different COL7A1 mutations

S. Shinkuma, W. Nishie, K. Natsuga, H. Nakamura, K. Ito, M. Akiyama, H. Shimizu

EXPERIMENTAL DERMATOLOGY, 19(11) 1032-1032, Nov, 2010

Research Projects

Development of a novel therapeutic strategy for angiosarcoma through drug screening

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
Genome-wide screening of the key molecules for metastasizing collagen VII-deficient squamous cell carcinoma.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Nakamura Hideki
Establishment of cicatricial alopecia animal models

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Nakamura Hideki
Elucidating roles of plasmin in blister formation of bullous pemphigoid

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Nakamura Hideki, NISHIE Wataru, NATSUGA Ken, SHIMIZU Hiroshi
Investigation of hematopoietic stem cell transplantation for epidermolysis bullosa

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SHIMIZU Hiroshi, ABE Riichiro, NISHIE Wataru, FUJITA Yasuyuki, AKIYAMA Masashi, KOJIMA Seiji, NAKAMURA Hideki
Objective Evaluation Method of Genetic Treatment for Epidermolysis bullosa

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

NAKAMURA Hideki, SHIMIZU Hiroshi, NISHIE Wataru

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