2006年
Disruptions of the fornix fiber in parkinsonian patients with excessive daytime sleepiness
PARKINSONISM & RELATED DISORDERS
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- 巻
- 12
- 号
- 5
- 開始ページ
- 319
- 終了ページ
- 322
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.parkreldis.2006.01.007
- 出版者・発行元
- ELSEVIER SCI LTD
Background: Although excessive daytime sleepiness (EDS) in Parkinson's disease (PD) has received a great deal of attention, the underlying pathological mechanism of its development and the relative contributions of brain function to this process are poorly understood.
Objective: To compare the fractional anisotropy (FA) values of PD patients with EDS and those without EDS, and to investigate the mechanism of EDS in this disease.
Methods: Eleven patients with PD with EDS, 26 patients with PD without EDS and 10 controls participated in this study. Patients with an ESS (Epworth Sleepiness Scale) score >= 10 were defined as having EDS. The FA values of 5 regions of interest (ROI) including the fornix were compared between the three groups.
Results: There were significant reductions in FA values of the fornix fiber in patients with EDS. ESS scores had significant correlation with FA values of the fornix.
Conclusions: Our study is the first to find the fornix fiber degeneration in PD patients with EDS. These results indicate that fornix dysfunction may have some correlations with EDS in PD. (c) 2006 Elsevier Ltd. All rights reserved.
Objective: To compare the fractional anisotropy (FA) values of PD patients with EDS and those without EDS, and to investigate the mechanism of EDS in this disease.
Methods: Eleven patients with PD with EDS, 26 patients with PD without EDS and 10 controls participated in this study. Patients with an ESS (Epworth Sleepiness Scale) score >= 10 were defined as having EDS. The FA values of 5 regions of interest (ROI) including the fornix were compared between the three groups.
Results: There were significant reductions in FA values of the fornix fiber in patients with EDS. ESS scores had significant correlation with FA values of the fornix.
Conclusions: Our study is the first to find the fornix fiber degeneration in PD patients with EDS. These results indicate that fornix dysfunction may have some correlations with EDS in PD. (c) 2006 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.parkreldis.2006.01.007
- ISSN : 1353-8020
- PubMed ID : 16621664
- Web of Science ID : WOS:000238603000010