Hirakawa Hidehiko

J-GLOBAL         Last updated: Nov 7, 2019 at 03:03
Hirakawa Hidehiko
University of Tsukuba
Faculty of Life and Environmental Sciences
Job title
Associate Professor

Research Areas


Academic & Professional Experience

Nov 2010
Feb 2018
Assistant Professor, Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
Apr 2010
Nov 2010
Project Assistant Professor, Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
Jan 2009
Mar 2010
Project Assistant Professor, School of Engineering, The University of Tokyo
Mar 2008
Jan 2009
Project postdoctoral fellow, School of Engineering, The University of Tokyo
Apr 2007
Mar 2008
Project postdoctoral fellow, Center for NanoBio Integration, The University of Tokyo


Apr 2000
Mar 2005
Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
Apr 1998
Mar 2000
Department of Chemistry and Biotechnology, Faculty of Engineering, The University of Tokyo
Apr 1996
Mar 1998
Natural Sciences I, College of Arts and Sciences: Junior Division, The University of Tokyo

Committee Memberships

May 2015
Scientific Reports (Nature Publishing Group)  Editorial Board Member

Awards & Honors

Jun 2011
Artificial self-sufficient P450: Noncovalent complex with electron transfer components, FEBS Journal Klaus Ruckpaul poster award
Winner: Hidehiko Hirakawa
May 2011
Noncovalent Complex Formation of a Bacterial Cytochrome P450 and its Electron transfer Proteins by Fusion to PCNA, The outstanding award for Young Scientist and Student of oral presentation, Asian Congress on Biotechnology 2011

Research Grants & Projects

Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2018 - Mar 2021    Investigator(s): Hidehiko Hirakawa
Grant-in-Aid for Challenging Exploratory Research
Project Year: Apr 2014 - Mar 2016    Investigator(s): Hidehiko Hirakawa
Complete Self-sufficient P450 with Cofactor Regeneration Domain
Project Year: Jan 2011 - Dec 2011    Investigator(s): Hidehiko Hirakawa
JSPS: Grant-in-Aid for Young Scientists (B)
Project Year: Apr 2009 - Mar 2011    Investigator(s): Hidehiko Hirakawa

Published Papers

平川, 秀彦
バイオサイエンスとインダストリー   77(1) 32-36   Jan 2019
Haga, Tomoaki; Hirakawa, Hidehiko; Nagamune, Teruyuki
Biotechnology journal   13(12) 1800088   Dec 2018   [Refereed]
Most bacterial cytochrome P450 monooxygenases (P450s) do not work alone because their active species is generated by two electrons supplied through two separate auxiliary proteins. Artificial "self-sufficient" P450s, in which one molecule each of ...
平川, 秀彦;長棟, 輝行
化学と生物   51(8) 521-523   Aug 2013
Iwata, Fumiya; Hirakawa, Hidehiko; Nagamune, Teruyuki
Biotechnology journal   13(11) 1700662   Nov 2018   [Refereed]
Bacterial cytochrome P450 monooxygenases (P450s) are promising biocatalysts for chemical syntheses because they catalyze a variety of oxidations on non-activated hydrocarbons using O . However, the requirement of two auxiliary proteins, an electro...
Yoo, Si-Youl;Min, Junhong;Haga, Tomoaki;Hirakawa, Hidehiko;Nagamune, Teruyuki;Jeong-Woo, Choi
Journal of Nanoscience and Nanotechnology   17(8) 5189-5192   Aug 2017   [Refereed]

Conference Activities & Talks

Protein engineering for practical enzymatic protein/peptide ligation
第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会   24 Jun 2019   
平川, 秀彦
第31回生物無機化学夏季セミナー   13 Sep 2018   
What is happening in an artificial self-sufficient cytochrome P450?
Hirakawa, Hidehiko
The 15th Japan-China-Korea Joint Symposium on Enzyme Engineering   30 Jun 2018   
人為的な酵素の集合化に関する研究 [Invited]
酵素工学研究会第78回講演会   6 Oct 2017   
芳賀, 智亮;平川, 秀彦;長棟, 輝行
化学工学会第49回秋季大会   21 Sep 2017   
岩田, 史也;平川, 秀彦;長棟, 輝行
第69回日本生物工学会大会   12 Sep 2017   
Benefits from artificial assembly with redox partners [Invited]
20th International Conference on Cytochrome P450: Biochemistry, Biophysics and Biotechnology   27 Aug 2017   
畠山, 洋平;平川, 秀彦;長棟, 輝行
化学工学会第82年会   7 Mar 2017   
Competitive detection of interaction between cytochrome P450 and electron transfer protein
Kondo, Masayoshi;Hirakawa, Hidehiko;Nagamune, Teruyuki
The Fifth International Conference on Cofactors and Active Enzyme Molecule 2016   7 Sep 2016   
畠山, 美沙樹;平川, 秀彦;長棟, 輝行
化学工学会群馬大会2015   27 Nov 2015   

Books etc

Immobilization of Cells and Biomolecules for Functional Fabrication
平川, 秀彦 (Part:Contributor, ヘテロ三量体タンパク質を利用したシトクロムP450モノオキシゲナーゼの効果的固定化)
シーエムシー出版   Apr 2018   ISBN:9784781313
Enzyme Engineering
Hirakawa, Hidehiko;Nagamune, Teruyuki (Part:Contributor, Use of sulfolobus solfataricus PCNA subunit proteins to direct the assembly of multimeric enzyme complexes)
Jan 2013   
Nanoscale Biocatalysis
Hirakawa, Hidehiko;Nagamune, Teruyuki (Part:Contributor, Nanoscale-engineered cytochrome p450 system with a branch structure)
Jan 2011   
Development of enzymatic catalysts working in nonaqueous media
Mar 2005   

Teaching Experience