論文

査読有り 国際誌
2014年6月

Effects of acute hypoxia on cerebrovascular responses to carbon dioxide.

Experimental physiology
  • Shigehiko Ogoh
  • ,
  • Hidehiro Nakahara
  • ,
  • Shinya Ueda
  • ,
  • Kazunobu Okazaki
  • ,
  • Manabu Shibasaki
  • ,
  • Andrew W Subudhi
  • ,
  • Tadayoshi Miyamoto

99
6
開始ページ
849
終了ページ
58
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1113/expphysiol.2013.076802

In normoxic conditions, a reduction in arterial carbon dioxide tension causes cerebral vasoconstriction, thereby reducing cerebral blood flow and modifying dynamic cerebral autoregulation (dCA). It is unclear to what extent these effects are altered by acute hypoxia and the associated hypoxic ventilatory response (respiratory chemoreflex). This study tested the hypothesis that acute hypoxia attenuates arterial CO2 tension-mediated regulation of cerebral blood flow to help maintain cerebral O2 homeostasis. Eight subjects performed three randomly assigned respiratory interventions following a resting baseline period, as follows: (1) normoxia (21% O2); (2) hypoxia (12% O2); and (3) hypoxia with wilful restraint of the respiratory chemoreflex. During each intervention, 0, 2.0, 3.5 or 5.0% CO2 was sequentially added (8 min stages) to inspired gas mixtures to assess changes in steady-state cerebrovascular CO2 reactivity and dCA. During normoxia, the addition of CO2 increased internal carotid artery blood flow and middle cerebral artery mean blood velocity (MCA Vmean), while reducing dCA (change in phase = -0.73 ± 0.22 rad, P = 0.005). During acute hypoxia, internal carotid artery blood flow and MCA Vmean remained unchanged, but cerebrovascular CO2 reactivity (internal carotid artery, P = 0.003; MCA Vmean, P = 0.031) and CO2-mediated effects on dCA (P = 0.008) were attenuated. The effects of hypoxia were not further altered when the respiratory chemoreflex was restrained. These findings support the hypothesis that arterial CO2 tension-mediated effects on the cerebral vasculature are reduced during acute hypoxia. These effects could limit the degree of hypocapnic vasoconstriction and may help to regulate cerebral blood flow and cerebral O2 homeostasis during acute periods of hypoxia.

リンク情報
DOI
https://doi.org/10.1113/expphysiol.2013.076802
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24632495
ID情報
  • DOI : 10.1113/expphysiol.2013.076802
  • PubMed ID : 24632495

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