論文

査読有り 国際誌
2013年3月

Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries.

Experimental physiology
  • Shigehiko Ogoh
  • ,
  • Kohei Sato
  • ,
  • Hidehiro Nakahara
  • ,
  • Kazunobu Okazaki
  • ,
  • Andrew W Subudhi
  • ,
  • Tadayoshi Miyamoto

98
3
開始ページ
692
終了ページ
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1113/expphysiol.2012.068015

Hypoxia changes the regional distribution of cerebral blood flow and stimulates the ventilatory chemoreflex, thereby reducing CO2 tension. We examined the effects of both hypoxia and isocapnic hypoxia on acute changes in internal carotid (ICA) and vertebral artery (VA) blood flow. Ten healthy male subjects underwent the following two randomly assigned respiratory interventions after a resting baseline period with room air: (i) hypoxia; and (ii) isocapnic hypoxia with a controlled gas mixture (12% O2; inspiratory mmHg). In the isocapnic hypoxia intervention, subjects were instructed to maintain the rate and depth of breathing to maintain the level of end-tidal partial pressure of CO2 ( ) during the resting baseline period. The ICA and VA blood flow (velocity × cross-sectional area) were measured using Doppler ultrasonography. The was decreased (-6.3 ± 0.9%, P < 0.001) during hypoxia by hyperventilation (minute ventilation +12.9 ± 2.2%, P < 0.001), while was unchanged during isocapnic hypoxia. The ICA blood flow was unchanged (P = 0.429), while VA blood flow increased (+10.3 ± 3.1%, P = 0.010) during hypoxia. In contrast, isocapnic hypoxia increased both ICA (+14.5 ± 1.4%, P < 0.001) and VA blood flows (+10.9 ± 2.4%, P < 0.001). Thus, hypoxic vasodilatation outweighed hypocapnic vasoconstriction in the VA, but not in the ICA. These findings suggest that acute hypoxia elicits an increase in posterior cerebral blood flow, possibly to maintain essential homeostatic functions of the brainstem.

リンク情報
DOI
https://doi.org/10.1113/expphysiol.2012.068015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23143991
ID情報
  • DOI : 10.1113/expphysiol.2012.068015
  • PubMed ID : 23143991

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