論文

査読有り 国際誌
2020年8月19日

Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with chronic obstructive pulmonary disease.

Clinical nutrition (Edinburgh, Scotland)
  • Kuniaki Hirai
  • ,
  • Akihiko Tanaka
  • ,
  • Tetsuya Homma
  • ,
  • Yuiko Goto
  • ,
  • Kaho Akimoto
  • ,
  • Tomoki Uno
  • ,
  • Uchida Yoshitaka
  • ,
  • Yoshito Miyata
  • ,
  • Hideki Inoue
  • ,
  • Shin Ohta
  • ,
  • Shintaro Suzuki
  • ,
  • Hironori Sagara

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.clnu.2020.08.010

BACKGROUND & AIMS: Sarcopenia is common in patients with chronic obstructive pulmonary disease (COPD). Serum creatinine/cystatin C (Cr/CysC) ratio has attracted attention as a surrogate marker for sarcopenia but has not been adequately studied in patients with COPD. Thus, the purpose of this study was to investigate the validity of serum Cr/CysC ratio as a predictor of sarcopenia, evaluate a statistical cut-off value, and assess the relationship between Cr/CysC ratio and clinical factors. METHODS: In this prospective observational study, we enrolled 234 male outpatients with COPD. We determined the relevance of serum Cr/CysC ratio as a surrogate maker for sarcopenia by comparing it with various biomarkers and prospectively investigated the relationship of Cr/CysC ratio with the annual exacerbation rate. RESULTS: Serum Cr/CysC was significantly correlated with handgrip strength (r = 0.53, P < 0.01) and muscle mass (r = 0.44, P < 0.01). The area under the curve for sarcopenia was significantly larger for serum Cr/CysC ratio than for other biomarkers (Cr/CysC: 0.87, CysC: 0.63, Cr: 0.61, albumin: 0.57). Multivariate analysis showed no significant difference in the frequency of acute exacerbations between patients in the low- and high-Cr/CysC group, defined by the cutoff value 0.71; however, the frequency of severe acute exacerbations was significantly higher in the low-Cr/CysC group. CONCLUSION: Serum Cr/CysC ratio can be used accurately, inexpensively, and easily to evaluate sarcopenia in male patients with COPD. Our study shows that patients with Cr/CysC below 0.71 have poor physical clinical factors and are at high risk of severe acute COPD exacerbations.

リンク情報
DOI
https://doi.org/10.1016/j.clnu.2020.08.010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32863062

エクスポート
BibTeX RIS