論文

査読有り 国際誌
2020年6月24日

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.

Nature communications
  • Yingsong Lin
  • Masahiro Nakatochi
  • Yasuyuki Hosono
  • Hidemi Ito
  • Yoichiro Kamatani
  • Akihito Inoko
  • Hiromi Sakamoto
  • Fumie Kinoshita
  • Yumiko Kobayashi
  • Hiroshi Ishii
  • Masato Ozaka
  • Takashi Sasaki
  • Masato Matsuyama
  • Naoki Sasahira
  • Manabu Morimoto
  • Satoshi Kobayashi
  • Taito Fukushima
  • Makoto Ueno
  • Shinichi Ohkawa
  • Naoto Egawa
  • Sawako Kuruma
  • Mitsuru Mori
  • Haruhisa Nakao
  • Yasushi Adachi
  • Masumi Okuda
  • Takako Osaki
  • Shigeru Kamiya
  • Chaochen Wang
  • Kazuo Hara
  • Yasuhiro Shimizu
  • Tatsuo Miyamoto
  • Yuko Hayashi
  • Hiromichi Ebi
  • Tomohiro Kohmoto
  • Issei Imoto
  • Yumiko Kasugai
  • Yoshinori Murakami
  • Masato Akiyama
  • Kazuyoshi Ishigaki
  • Koichi Matsuda
  • Makoto Hirata
  • Kazuaki Shimada
  • Takuji Okusaka
  • Takahisa Kawaguchi
  • Meiko Takahashi
  • Yoshiyuki Watanabe
  • Kiyonori Kuriki
  • Aya Kadota
  • Rieko Okada
  • Haruo Mikami
  • Toshiro Takezaki
  • Sadao Suzuki
  • Taiki Yamaji
  • Motoki Iwasaki
  • Norie Sawada
  • Atsushi Goto
  • Kengo Kinoshita
  • Nobuo Fuse
  • Fumiki Katsuoka
  • Atsushi Shimizu
  • Satoshi S Nishizuka
  • Kozo Tanno
  • Ken Suzuki
  • Yukinori Okada
  • Momoko Horikoshi
  • Toshimasa Yamauchi
  • Takashi Kadowaki
  • Herbert Yu
  • Jun Zhong
  • Laufey T Amundadottir
  • Yuichiro Doki
  • Hideshi Ishii
  • Hidetoshi Eguchi
  • David Bogumil
  • Christopher A Haiman
  • Loic Le Marchand
  • Masaki Mori
  • Harvey Risch
  • Veronica W Setiawan
  • Shoichiro Tsugane
  • Kenji Wakai
  • Teruhiko Yoshida
  • Fumihiko Matsuda
  • Michiaki Kubo
  • Shogo Kikuchi
  • Keitaro Matsuo
  • 全て表示

11
1
開始ページ
3175
終了ページ
3175
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-020-16711-w

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) genome-wide significant loci (P < 5.0 × 10-8), of which 16p12.3 has not been reported in the Western population. The lead single nucleotide polymorphism (SNP) at 16p12.3 is rs78193826 (odds ratio = 1.46, 95% confidence interval = 1.29-1.66, P = 4.28 × 10-9), an Asian-specific, nonsynonymous glycoprotein 2 (GP2) gene variant. Associations between selected GP2 gene variants and pancreatic cancer are replicated in 10,822 additional cases and controls of East Asian origin. Functional analyses using cell lines provide supporting evidence of the effect of rs78193826 on KRAS activity. These findings suggest that GP2 gene variants are probably associated with pancreatic cancer susceptibility in populations of East Asian ancestry.

リンク情報
DOI
https://doi.org/10.1038/s41467-020-16711-w
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32581250
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314803
ID情報
  • DOI : 10.1038/s41467-020-16711-w
  • PubMed ID : 32581250
  • PubMed Central 記事ID : PMC7314803

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