Hideyuki Mukai

Profile Information

Affiliation: 准教授, バイオシグナル総合研究センター, 神戸大学

Degree: M.D., Ph.D.

J-GLOBAL ID: 201101025633584280
researchmap Member ID: B000002038

External link: http://bioupdate.jp

Research Interests

Research Areas

Papers

Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice

Shunsuke Uehara, Hideyuki Mukai, Teruhito Yamashita, Masanori Koide, Kohei Murakami, Nobuyuki Udagawa, Yasuhiro Kobayashi

Journal of Bone and Mineral Metabolism, 40(2) 251-261, Jan 14, 2022
Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice.

Atsushi Kawase, Hideyuki Mukai, Shunsuke Tateishi, Shintaro Kuroda, Akira Kazaoka, Ryosuke Satoh, Hiroaki Shimada, Reiko Sugiura, Masahiro Iwaki

The Journal of pharmacology and experimental therapeutics, 379(1) 53-63, Jul 26, 2021
PKN2 is involved in aggregation and spheroid formation of fibroblasts in suspension culture by regulating cell motility and N-cadherin expression

Koji Kubouchi, Hideyuki Mukai

Biochemistry and Biophysics Reports, 25 100895-100895, Mar, 2021 Peer-reviewed
PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation

Hiroki Yasuda, Hikaru Yamamoto, Kenji Hanamura, Mona Mehruba, Toshio Kawamata, Hiromi Morisaki, Masaaki Miyamoto, Shinji Takada, Tomoaki Shirao, Yoshitaka Ono …

Communications Biology, 3(1), Dec, 2020 Peer-reviewedCorresponding author
プロテインキナーゼN3(Pkn3)阻害剤は、卵巣切除に伴う骨量減少を骨吸収抑制により軽減する

上原俊介, 山下照仁, 村上康平, 小出雅則, 宇田川信之, 小林泰浩, 向井秀幸

日本骨代謝学会学術集会プログラム抄録集, 38回 128-128, Oct, 2020
マウスにおけるシトクロムP450誘導過程におけるプロテインキナーゼNファミリーの役割

川瀬篤史, 向井秀幸, 立石駿介, 黒田真太郎, 松田尚也, 佐藤亮介, 島田紘明, 杉浦麗子, 岩城正宏

日本薬学会年会要旨集, 140年会 27X-pm02, Mar, 2020
PKN1 controls the aggregation, spheroid formation, and viability of mouse embryonic fibroblasts in suspension culture.

Mehruba M, Siddique SM, Mukai H

Biochemical and biophysical research communications, Dec, 2019 Peer-reviewed
PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes.

Salman Mahmud Siddique, Koji Kubouchi, Yuka Shinmichi, Nana Sawada, Reiko Sugiura, Yasushi Itoh, Shunsuke Uehara, Kanae Nishimura, Shunsuke Okamura, Hiroyuki Ohsaki …

Scientific reports, 9(1) 13977-13977, Sep 27, 2019 Peer-reviewed
Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.

Shunsuke Uehara, Nobuyuki Udagawa, Hideyuki Mukai, Akihiro Ishihara, Kazuhiro Maeda, Teruhito Yamashita, Kohei Murakami, Michiru Nishita, Takashi Nakamura, Shigeaki Kato …

Science signaling, 10(494), Aug 29, 2017 Peer-reviewed
Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1

Rana Mashud, Akira Nomachi, Akihide Hayakawa, Koji Kubouchi, Sally Danno, Takako Hirata, Kazuhiko Matsuo, Takashi Nakayama, Ryosuke Satoh, Reiko Sugiura …

SCIENTIFIC REPORTS, 7(1) 7663, Aug, 2017 Peer-reviewed
PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts

Sally Danno, Koji Kubouchi, Mona Mehruba, Manabu Abe, Rie Natsume, Kenji Sakimura, Satoshi Eguchi, Masahiro Oka, Masanori Hirashima, Hiroki Yasuda …

GENES TO CELLS, 22(2) 220-236, Feb, 2017 Peer-reviewed
S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease

Yuma Sonoda, Ikuo Tooyama, Hideyuki Mukai, Kiyoshi Maeda, Haruhiko Akiyama, Toshio Kawamata

NEUROPATHOLOGY, 36(4) 325-332, Aug, 2016 Peer-reviewed
PKN3 is the major regulator of angiogenesis and tumor metastasis in mice

Hideyuki Mukai, Aiko Muramatsu, Rana Mashud, Koji Kubouchi, Sho Tsujimoto, Tsunaki Hongu, Yasunori Kanaho, Masanobu Tsubaki, Shozo Nishida, Go Shioi …

SCIENTIFIC REPORTS, 6 18979, Jan, 2016 Peer-reviewed
PKN3ノックアウトマウスを用いた新たな血管新生とがん転移シグナルの制御機構

窪内康二, 辻本翔, 神田勇輝, 小野祐輝, 木戸友絵, 澤田奈々, 西田升三, 椿正寛, Rana Mashud, 向井秀幸 …

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2P1146]-[2P1146], Dec, 2015
Turning off of GluN2B subunits and turning on of CICR in hippocampal LTD induction after developmental GluN2 subunit switch

Hiroki Yasuda, Hideyuki Mukai

HIPPOCAMPUS, 25(11) 1274-1284, Nov, 2015 Peer-reviewed
Protein Kinase N1 Is a Novel Substrate of NFATc1-mediated Cyclin D1-CDK6 Activity and Modulates Vascular Smooth Muscle Cell Division and Migration Leading to Inward Blood Vessel Wall Remodeling

Nikhlesh K. Singh, Venkatesh Kundumani-Sridharan, Sanjay Kumar, Shailendra K. Verma, Sivareddy Kotla, Hideyuki Mukai, Mark R. Heckle, Gadiparthi N. Rao

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(43) 36291-36304, Oct, 2012 Peer-reviewed
Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes

Katsuya Kajimoto, Dan Shao, Hiromitsu Takagi, Gregorio Maceri, Daniela Zablocki, Hideyuki Mukai, Yoshitaka Ono, Junichi Sadoshima

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 300(1) H191-H200, Jan, 2011 Peer-reviewed
Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

Yuma Sonoda, Hideyuki Mukai, Kazuhiko Matsuo, Mikiko Takahashi, Yoshitaka Ono, Kiyoshi Maeda, Haruhiko Akiyama, Toshio Kawamata

NEUROSCIENCE LETTERS, 471(1) 20-24, Feb, 2010 Peer-reviewed
Development of an intracellularly acting inhibitory peptide selective for PKN

Kazuhiro Shiga, Kentaro Takayama, Shiroh Futaki, Jessica E. Hutti, Lewis C. Cantley, Katsuko Ueki, Yoshitaka Ono, Hideyuki Mukai

BIOCHEMICAL JOURNAL, 425(2) 445-453, Jan, 2010 Peer-reviewed
A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles

Hisato Sugata, Kazuhiko Matsuo, Taisuke Nakagawa, Mikiko Takahashi, Hideyuki Mukai, Yoshitaka Ono, Kiyoshi Maeda, Haruhiko Akiyama, Toshio Kawamata

NEUROSCIENCE LETTERS, 459(2) 96-99, Aug, 2009 Peer-reviewed

Misc.

PKN1はリンパ球の細胞運動・トラフィッキングを制御する

窪内康二, 團野紗莉, 野町昭, 平田多佳子, 松尾一彦, 中山隆志, 佐藤亮介, 杉浦麗子, 阿部学, 崎村建司 …

生命科学系学会合同年次大会, 2017年度 [1P-0369], Dec, 2017 Peer-reviewed
Wnt5a-Ror2シグナルによる骨吸収活性調節の病態モデルにおける役割

上原俊介, 山下照仁, 中村貴, 加藤茂明, 宇田川信之, 高橋直之, 小林泰浩, 西田満, 南康博, 向井秀幸 …

日本骨代謝学会学術集会プログラム抄録集, 35回 158-158, Jul, 2017
PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts (vol 22, pg 220, 2017)

Sally Danno, Koji Kubouchi, Mona Mehruba, Manabu Abe, Rie Natsume, Kenji Sakimura, Satoshi Eguchi, Masahiro Oka, Takeshi Fukumoto, Masanori Hirashima …

GENES TO CELLS, 22(3) 328-328, Mar, 2017
Synaptic maturation by PKN during development

Hiroki Yasuda, Yoshitaka Ono, Hideyuki Mukai

NEUROSCIENCE RESEARCH, 65 S82-S82, 2009
アルツハイマー病におけるPDK1活性化の検討

中川泰介, 菅田陽怜, 松尾和彦, 高橋美樹子, 向井秀幸, 小野功貴, 前田潔, 秋山治彦, 川又敏男

Dement Jpn, 22(2) 171, Aug 15, 2008
カオリン誘発水頭症ラットにおけるプロテインキナーゼN(PKN)の断片化

酒井規雄, 沖井則文, 天野託, 関貴弘, 向井秀幸, 小野功貴, 栗栖薫

日本薬理学雑誌, 130(3) 10P-10P, Sep, 2007
Roles of PKN and PKCS in Alzheimer's disease

T Taniguchi, T Kawamata, H Mukai, H Hasegawa, T Isagawa, M Nakai, Y Ono, C Tanaka

JOURNAL OF NEUROCHEMISTRY, 78 136-136, Sep, 2001
Phosphorylation of tau is regulated by PKN (vol 276, pg 10025, 2001)

T Taniguchi, T Kawamata, H Mukai, H Hasegawa, T Isagawa, M Yasuda, T Hashimoto, A Terashima, M Nakai, H Mori …

JOURNAL OF BIOLOGICAL CHEMISTRY, 276(25) 23212-23212, Jun, 2001
Association of immature hypo-phosphorylated PKC epsilon with an anchoring protein CG-NAP

M Takahashi, H Mukai, K Oishi, T Isagawa, Y Ono

FASEB JOURNAL, 15(5) A723-A723, Mar, 2001
Protein kinase C delta is a dominant kinase in porcine aorta for activation of CPI-17, a smooth muscle myosin phosphatase inhibitor.

M Eto, M Yazawa, T Kitazawa, H Mukai, Y Ono, DL Brautigan

BIOPHYSICAL JOURNAL, 80(1) 392A-392A, Jan, 2001
PKNによるタウ蛋白リン酸化状態の制御

谷口泰造, 川又敏男, 長谷川浩史, 向井秀幸, 砂河孝行, 小野功貴, 田中千賀子, 三好功峰

日本分子生物学会年会プログラム・講演要旨集, 23rd 681, Nov 25, 2000
アルツハイマー神経原線維変化には小胞関連蛋白 Rabaptin-5 が蓄積している

川又敏男, 向井秀幸, 小野功貴, 三好功峰, 田中千賀子

Neuropathology : official journal the Japanese Society of Neuropathology, 20 19-19, Jun 1, 2000
神経原線維変化と小胞体の関連について

川又敏男, 谷口泰造, 長谷川浩史, 向井秀幸, 小野功貴, 田中千賀子

Neuropathology : official journal the Japanese Society of Neuropathology, 19 224-224, Jun 3, 1999
The formation of actin stress fiber formation by microtubule disruption

ENOMOTO Taira, MUKAI Hideyuki, YOSHINAGA Chiho, SUGAI Motoyuki

21 526-526, Dec 1, 1998
Protein kinase PKN

MUKAI Hideyuki, ONO Yoshitaka

70(11) 1335-1339, Nov 25, 1998
アルツハイマー病患者脳内PKNの局在について

川又敏男, 谷口泰造, 北川道憲, 向井秀幸, 橋本健志, 前田潔, 小野功貴, 田中千賀子

Neuropathology : official journal the Japanese Society of Neuropathology, 18 190-190, May 28, 1998
Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN.

Kaori Matsuzawa, Hidetaka Kosako, Naoyuki Inagaki, Hideki Shibata, Hideyuki Mukai, Yoshitaka Ono, Mutsuki Amano, Kozo Kaibuchi, Yoshiharu Matsuura, Ichiro Azuma …

Collected papers from the Institute of Immunological Science Hokkaido University, 20 192-196, 1997
PKNのRhoA結合領域の決定とGTPase活性に対する効果

柴田秀樹, 向井秀幸, 稲垣好昌, 本間好, 木村一志, 貝淵弘三, 成宮周, 小野功貴

日本分子生物学会年会プログラム・講演要旨集, 19 320-320, Aug 1, 1996
PNKはニューロフィラメントのヘッド-ロッド領域に結合し燐酸化する

敏森将直, 向井秀幸, 柴田秀樹, 北川道憲, 嶋川真木, 宮原昌子, 高永博実, 砂川博子, 小野功貴

日本分子生物学会年会プログラム・講演要旨集, 19 613-613, Aug 1, 1996
PKNの分子内相互作用とそのアミノ末端側領域に存在する偽基質領域の解析

北川道憲, 柴田秀樹, 敏森将直, 向井秀幸, 小野功貴

日本分子生物学会年会プログラム・講演要旨集, 19 613-613, Aug 1, 1996

Books and Other Publications

Neuromethods:Protein kinase technologies

Hideyuki Mukai (Role: Contributor, Electorphysiological technique for the analysis of the synaptic function of PKN1 in the hippocampus.)

2012
Protein kinase Technologies

Hideyuki Mukai (Role: Editor)

Springer-Verlag, 2012
Welcome to ゲノムワールドゲノム創薬科学最前線

向井秀幸 (Role: Contributor, マウスにおける遺伝子ノックアウトとその応用)

京都廣川書店, 2010
Methods in Enzymology:Regulators and Effectors of Small GTPases: Rho Family

Hideyuki Mukai (Role: Contributor, Purification and Kinase Assay of PKN)

Elsevier, 2006
Protein kinase C Protocols

Hideyuki Mukai (Role: Contributor, Expression and Purification of Protein Kinase C from Insect Cells)

Humana Press, 2003
Encyclopedia of Molecular Medicine

Hideyuki Mukai (Role: Contributor, PKN protein kinase)

John Wiley & Sons, Inc., 2002
ニューロサイエンス講座「神経の情報伝達」 - 理論と実際 - 第2巻「新しい神経伝達研究法・II」

向井秀幸 (Role: Contributor, 大腸菌でのタンパク質の発現)

広川書店, 2000
Molecular Medicine Vol. 36 臨時増刊号「細胞のシグナリング」

向井秀幸 (Role: Contributor, プロテインキナ－ゼC関連酵素：PKNとPKB/Akt)

中山書店, 1999
タンパク質化学第9巻「脳・神経タンパク質、接着タンパク質」

向井秀幸 (Role: Contributor, カルシニューリンＡ、Ｂ)

広川書店, 1995
生体における情報伝達

向井秀幸 (Role: Contributor, グアニレートシクラーゼ系 - cGMP)

南江堂, 1993
医学・生理学系のためのＡＴ互換機活用法

向井秀幸 (Role: Contributor, プレゼンテーションと画像データの取り扱い)

秀潤社, 1993
症例による内科学（藤田拓男編）

向井秀幸 (Role: Contributor, 輸血後ＧＶＨＤ)

ファーマメディカ社, 1992
MEFINFO 86

Hideyuki Mukai (Role: Joint author, Study on glucose tolerance using a mathematical model with a derivative insulin secretory mechanism-A kinetic analysis of glucose and insulin curves during intravenous glucose tolerance tests)

Elsevier Science Publishers B.V., 1986

Presentations

PKN Interacting Proteins

Hideyuki Mukai

International Conference on Molecular Biology Transcription/Replication Factors and Signal Transduction, 1999

Research Projects

不安を緩衝する腹側海馬神経回路の探索

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

安田浩樹, 惣谷和広, 向井秀幸, 吉田史章
ストレス誘発性不安緩衝における海馬歯状回抑制性細胞の重要性

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2023

安田浩樹, 向井秀幸, 惣谷和広
Analysis on the suppression of cancer metastasis by PKN3 inhibition

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Mukai Hideyuki
Involvement of glutamate transporters in central stress response

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Hiroki Yasuda, MUKAI Hideyuki, OHNISHI Hiroshi
タウ蛋白とリン酸化酵素複合体の相互作用を介した認知症脳神経細胞死の病態解析

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2011 - Mar, 2015

川又敏男, 小野功貴, 向井秀幸, 高橋美樹子, 前田潔
PKN1 regulates metaplasticity in hippocampus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

YASUDA Hiroki, MUKAI Hideyuki, KOJIMA Nobuhiko
タウ蛋白リン酸化シグナル巨大複合体を介する変性認知症の神経細胞死に関する病態解析

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2014 - 2015

川又敏男, 向井秀幸, 高橋美樹子, 秋山治彦, 前田潔
Functional analysis of separase and its novel substrate in the licensing of centrosome duplication

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

TAKAHASHI Mikiko, TADA Shusuke, MUKAI Hideyuki, MATSUO Kazuhiko
Pharmacogenomic study on the drug-sensitive genes using model organisms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

KUNO Takayoshi, MA Yan, MUKAI Hideyuki
Pathological study for a protein anchoring tau kinases and tau phosphatases in Alzheimer brain tissues

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

KAWAMATA Toshio, ONO Yoshitaka, MUKAI Hideyuki, TAKAHASHI Mikiko, MAEDA Kiyoshi
Regulation of the maturation of cerebellar synapses by PKN

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

YASUDA Hiroki, MUKAI Hideyuki
Research of signal transduction to neuronal degeneration mediated by tau-kinases complex in dementia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

KAWAMATA Toshio, MAEDA Kiyoshi, ONO Yoshitaka, MUKAI Hideyuki, TAKAHASHI Mikiko
An analysis of the role of protein kinase PKN3 in the progress of cancer and a development of new anticancer agent

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

MUKAI Hideyuki
蛋白質リン酸化酵素PKN1ノックアウトマウスを用いた記憶・学習機構の解析

科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2006 - 2007

向井秀幸
Functional regulation of centrosome and Golgi apparatus by signal-anchoring proteins.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2007

ONO Yoshitaka, MOKAI Hideyuki, TAKAHASHI Mikiko
Research of signal transduction to neuronal degeneration mediated by tau phorphorylation in dementia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

KAWAMATA Toshio, MAEDA Kiyoshi, ONO Yoshitaka, MUKAI Hideyuki, TAKAHASHI Mikiko
Role of β isoform of protein kinase C in hepatocyte growth factor-induced signal transduction in pigment cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

OKA Masahiro, MUKAI Hideyuki
To clarify the mechanism of activation of PKN and the interaction with target molecules in vivo

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

MUKAI Hideyuki
Study of signal transduction to neuronal death through tau phosphorylation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2003

KAWAMATA Toshio, MUKAI Hideyuki, ONO Yoshitaka, MAEDA Kiyoshi
Study of the role of protein kinase C-phosphoipase D signaling pathway in pigment cells.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

OKA Masahiro, MUKAI Hideyuki

Industrial Property Rights

特願2005-57600 PKN1ノックアウト動物、および向精神薬開発法

向井秀幸, 小野功貴

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Misc.

Books and Other Publications

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Research Projects

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