Nov 15, 2017
Ceftriaxone-induced Neurotoxicity in a Patient after Pancreas-Kidney Transplantation.
Internal medicine (Tokyo, Japan)
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- Volume
- 56
- Number
- 22
- First page
- 3103
- Last page
- 3107
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.2169/internalmedicine.8774-16
Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and a broad antimicrobial spectrum. We herein report a case of ceftriaxone-induced neurotoxicity in a 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus and sporadic phonation. The symptoms clearly disappeared shortly after withdrawal of the drug. Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways. Physicians should note that antibiotic-associated encephalopathy may develop in patients administered ceftriaxone, especially in those complicated with renal dysfunction.
- Link information
- ID information
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- DOI : 10.2169/internalmedicine.8774-16
- ISSN : 0918-2918
- Pubmed ID : 28943562
- Pubmed Central ID : PMC5725869