論文

2022年10月26日

Antimicrobials in the Hospital are Unevenly Discontinued on Weekdays.

Internal medicine (Tokyo, Japan)
  • Hideharu Hagiya
  • ,
  • Mika Uno
  • ,
  • Tsukasa Higashionna
  • ,
  • Hiroyuki Honda
  • ,
  • Fumio Otsuka

62
12
開始ページ
1739
終了ページ
1742
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.0707-22

Objective Amid the global spread of antimicrobial resistance, antimicrobial stewardship should be further promoted in the clinical setting. Our previous study suggested an intra-week disproportion of discontinuation of broad-spectrum antibiotics. We therefore explored the generalization of this prescription trend by investigating the use of all intravenous antibiotics. Methods A retrospective, observational study. Patients Between January 1, 2018, and December 31, 2020, we collected data on the initiation and discontinuation of intravenous antimicrobials on each day of the week and on days after holidays at Okayama University Hospital, Japan. We compared the monthly antimicrobial prescription initiation and discontinuation using the Kruskal-Wallis test and Mann-Whitney U-test with Bonferroni correction as a post-hoc procedure. Results Data from 15,293 hospitalized cases were analyzed. The initiation of antimicrobials differed slightly among days of the week, although this trend was clinically insignificant. Compared with the initiations, antimicrobial discontinuations were disproportionately biased among the weekdays, tending to occur on Mondays (p <0.001) about twice as often as on other days. Similarly, antimicrobials were unevenly discontinued on the day after holidays compared to other days (p <0.001), with an approximately 2-fold difference. The use of antimicrobials in the hospital was thus unequally terminated on weekdays. Conclusion To further promote antimicrobial stewardship, clinicians should be aware of the influence of behavioral, environmental, and social factors on antimicrobial prescription, which is seemingly beyond medical indications.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.0707-22
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36288987
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332975
ID情報
  • DOI : 10.2169/internalmedicine.0707-22
  • PubMed ID : 36288987
  • PubMed Central 記事ID : PMC10332975

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