2010年6月
Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior
NEURON
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- ,
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- 巻
- 66
- 号
- 6
- 開始ページ
- 896
- 終了ページ
- 907
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2010.05.011
- 出版者・発行元
- CELL PRESS
In the basal ganglia, convergent input and dopaminergic modulation of the direct striatonigral and the indirect striatopallidal pathways are critical in rewarding and aversive learning and drug addiction. To explore how the basal ganglia information is processed and integrated through these two pathways, we developed a reversible neurotransmission blocking technique, in which transmission of each pathway was selectively blocked by specific expression of transmission-blocking tetanus toxin in a doxycycline-dependent manner. The results indicated that the coordinated modulation of these two pathways was necessary for dopamine-mediated acute psychostimulant actions. This modulation, however, shifted to the predominant roles of the direct pathway in reward learning and cocaine sensitization and the indirect pathway in aversive behavior. These two pathways thus have distinct roles: the direct pathway critical for distinguishing associative rewarding stimuli from nonassociative ones and the indirect pathway for rapid memory formation to avoid aversive stimuli.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.neuron.2010.05.011
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201002227586130754
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20620875
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279420800012&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.neuron.2010.05.011
- ISSN : 0896-6273
- J-Global ID : 201002227586130754
- PubMed ID : 20620875
- Web of Science ID : WOS:000279420800012