論文

国際誌
2018年11月

Serum 5-S -cysteinyldopa behavior in the early phase of nivolumab treatment of 12 melanoma patients

The Journal of Dermatology
  • Toshikazu Omodaka
  • ,
  • Akane Minagawa
  • ,
  • Hisashi Uhara
  • ,
  • Kazumasa Wakamatsu
  • ,
  • Tomonobu Koizumi
  • ,
  • Yoshiharu Yokokawa
  • ,
  • Hiroshi Koga
  • ,
  • Ryuhei Okuyama

45
11
開始ページ
1340
終了ページ
1344
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/1346-8138.14605
出版者・発行元
Wiley

Along with the expansion of therapeutic options for metastatic melanoma, the development of useful biomarkers is urgently required to predict and monitor treatment response. Serum 5-S-cysteinyldopa (5-S-CD) has been identified as a diagnostic marker of malignant melanoma, but its utility as a biomarker for emerging therapeutic agents remains unknown. We assessed serum 5-S-CD in 12 metastatic melanoma patients (median age, 76 years; six men and six women) who had been treated with nivolumab (Nivo) at Shinshu University Hospital between 2014 and 2016. Serum 5-S-CD and lactate dehydrogenase levels before and at 3-6 weeks of Nivo treatment were obtained and their changes were compared with clinical responses as defined by the Response Evaluation Criteria in Solid Tumors criteria (version 1.1). A decrease of 10 nmol/L or more of serum 5-S-CD was observed only in partial response patients (2/3 cases, 67%), while an increase of 10 nmol/L or more of serum 5-S-CD was witnessed only in progressive disease patients (4/8 cases, 50%). Serum 5-S-CD changes were within ±10 nmol/L in the remaining six patients (partial response, one; stable disease, one; progressive disease, four). The results of the four moderately affected progressive disease patients were suspected to have been influenced by small-sized metastatic lesions, a mixed response that included diminished and enlarged metastatic lesions, prior therapy to Nivo with BRAF inhibitors or radiation, or the development of brain metastasis. Serum 5-S-CD in the early phase of Nivo treatment may be helpful to predict therapeutic response in metastatic melanoma.

リンク情報
DOI
https://doi.org/10.1111/1346-8138.14605
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30144152
ID情報
  • DOI : 10.1111/1346-8138.14605
  • ISSN : 0385-2407
  • ORCIDのPut Code : 82173183
  • PubMed ID : 30144152

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