生島弘彬 (Hiroaki IKUSHIMA) - マイポータル

基本情報

所属: 東京大学医学部附属病院呼吸器内科助教

研究者番号: 80719154
ORCID iD: https://orcid.org/0000-0002-7053-2841
J-GLOBAL ID: 202301005171305357
researchmap会員ID: R000059213

学歴

- 2022年5月

University of London, Master of Science in Data Science
- 2012年3月

東京大学医学部医学科
- 2010年3月

東京大学大学院医学系研究科, 博士（医学）

委員歴

2026年3月 - 現在

日本臨床腫瘍学会, Best of ESMO 部会員
2025年12月 - 現在

日本癌治療学会, 妊娠期がん診療ガイドライン作成委員
2025年4月 - 現在

日本呼吸器内視鏡学会, 評議員

主要な論文

119

Clinical utility of comprehensive genomic profiling in detecting actionable EGFR exon 20 insertions undetected by companion diagnostics: a case report

Hideaki Motomura, Hiroaki Ikushima, Mizuki Fukuchi, Yutaro Ueki, Yu Ito, Yu Mikami, Masanori Kawakami, Akihisa Mitani, Keita Nakao, Masaaki Sato …

International Journal of Lung Cancer 1(3) 100043-100043 2026年9月査読有り責任著者
Isolated Subcarinal Lymph Node Recurrence 24 Years After Treatment for Primary Tracheal Adenoid Cystic Carcinoma

Yuhei Suzuki, Hiroaki Ikushima, Mitsuhiro Yamamoto, Yutaro Ueki, Aya Shinozaki‐Ushiku, Masanori Kawakami, Akihisa Mitani, Yosuke Masamoto, Hidenori Kage

Respirology Case Reports 14(6) e70648 2026年6月10日査読有り責任著者
MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Hiroaki Ikushima, Hidenori Kage

Cancer Science 117(8) 2085-2097 2026年5月26日査読有り筆頭著者責任著者
Clinicogenomic Landscape of MTAP -Deleted Thoracic Malignancies Across US and Japanese Nationwide Cohorts: Impact of Concurrent CDKN2A Alterations and Driver Mutations

Hiroaki Ikushima, Kousuke Watanabe, Aya Shinozaki-Ushiku, Katsutoshi Oda, Hidenori Kage

JCO Precision Oncology 10(5) e2600100 2026年5月22日査読有り筆頭著者責任著者
Molecular heterogeneity of ERBB2-altered cancers: A pan-cancer landscape across US and Japanese cohorts

Hiroaki Ikushima, Hideaki Motomura, Kousuke Watanabe, Aya Shinozaki-Ushiku, Katsutoshi Oda, Hidenori Kage

npj Precision Oncology 10 278 2026年4月29日査読有り筆頭著者責任著者
Precision medicine in the first-line treatment of EGFR-mutated non-small cell lung cancer: moving beyond “one-size-fits-all”

Hiroaki Ikushima, Hidenori Kage

Translational Lung Cancer Research 15(4) 114 2026年4月26日査読有り招待有り筆頭著者
Targeting KIFC1 to disrupt centrosome clustering and trigger anaphase catastrophe in small-cell lung cancer

Natsuki Nakagawa, Minemichi Toda, Akiko Kunita, Masafumi Horie, Masakatsu Tokunaga, Hiroaki Ikushima, Mirei Ka, Takahiro Iida, Manabu Shigeoka, Yukinobu Ito …

JCI Insight 11(7) e199352 2026年4月8日査読有り
Modeling the Pretest Probability of Identifying Druggable Mutations in Lung Cancer Using Nationwide Comprehensive Genomic Profiling Data

Hiroaki Ikushima, Kousuke Watanabe, Aya Shinozaki-Ushiku, Satoshi Kodera, Norihiko Takeda, Katsutoshi Oda, Hidenori Kage

JCO Clinical Cancer Informatics 10 e2500269 2026年3月19日査読有り筆頭著者責任著者
Long‐Term Follow‐Up of Pleuroparenchymal Fibroelastosis Associated With Crohn's Disease

Yuhei Suzuki, Hiroaki Ikushima, Yutaro Ueki, Takashi Maeda, Keiichiro Hida, Keishi Yoshida, Chihiro Takeuchi, Hirokazu Urushiyama, Masanori Kawakami, Akihisa Mitani …

Respirology Case Reports 14(3) e70555 2026年3月11日査読有り責任著者
Prediction model for ctDNA detectability in liquid comprehensive genomic profiling of advanced pancreatic cancer based on Japanese real-world data

Hiroaki Ikushima, Kousuke Watanabe, Aya Shinozaki-Ushiku, Kazunaga Ishigaki, Satoshi Kodera, Norihiko Takeda, Mitsuhiro Fujishiro, Katsutoshi Oda, Hidenori Kage

ESMO Open 11(2) 106069-106069 2026年2月査読有り筆頭著者責任著者
Lung Adenocarcinoma Expressing an EML4-ALK Fusion Transcript With Premature Stop Codons and Response to Alectinib: A Case Report.

Mami Ozaki, Hiroaki Ikushima, Masaki Suzuki, Akira Yokoyama, Kensuke Fukuda, Kousuke Watanabe, Aya Shinozaki-Ushiku, Motohiro Kato, Tetsuo Ushiku, Hiroyuki Aburatani …

Thoracic cancer 16(15) e70146 2025年8月査読有り責任著者
Central Airway Invasion of Lung Squamous Cell Carcinoma Causing Bronchomediastinal Fistula and Mediastinitis

Hana Miyasaka, Hiroaki Ikushima, Masanori Kawakami, Akihisa Mitani, Hidenori Kage

Respirology Case Reports 13(6) e70233 2025年6月9日査読有り責任著者
Pan-cancer clinical and molecular landscape of MTAP deletion in nationwide and international comprehensive genomic data

Hiroaki Ikushima, Kousuke Watanabe, Aya Shinozaki-Ushiku, Katsutoshi Oda, Hidenori Kage

ESMO Open 10(4) 104535 2025年4月査読有り筆頭著者責任著者
Clinical utility of comprehensive genomic profiling in non-small cell lung cancer: An analysis of a nation-wide database

Koki Fujii, Michiko Ueki, Momoko Morishita, Hiroaki Ikushima, Hideaki Isago, Kousuke Watanabe, Katsutoshi Oda, Hidenori Kage

Lung Cancer 200 108099-108099 2025年2月査読有り
Improvement in Survival in Patients With Advanced Non-small Cell Lung Cancer

KEISHI YOSHIDA, KAORU WATANABE, TAKU NISHIMURA, HIROAKI IKUSHIMA, SAYAKA OHARA, HIDEYUKI TAKESHIMA, TOSHIO SAKATANI, KAZUHIRO USUI

Anticancer Research 45(1) 295-305 2024年12月30日査読有り
A machine learning-based analysis of nationwide cancer comprehensive genomic profiling data across cancer types to identify features associated with recommendation of genome-matched therapy

Hiroaki Ikushima, Kousuke Watanabe, Aya Shinozaki-Ushiku, Katsutoshi Oda, Hidenori Kage

ESMO Open 9(12) 103998 2024年12月査読有り筆頭著者責任著者
Transdifferentiation of cervical squamous cell carcinoma with ERBB2 amplification to adenocarcinoma: whole genome sequence analysis and successful control by anti-HER2 therapy

Hiroaki Ikushima, Kiyoshi Yamaguchi, Yoichi Furukawa, Seiya Imoto, Hirotomo Koda, Takuro Mizukami, Teppei Morikawa, Keita Uchino

British Journal of Cancer Reports 1(1) 12 2023年9月4日査読有り筆頭著者責任著者
Identification of age-dependent features of human bronchi using explainable artificial intelligence

Hiroaki Ikushima, Kazuhiro Usui

European Respiratory Journal Open Research 9(5) 00362-2023 2023年8月17日査読有り筆頭著者責任著者
Successful control of intestinal bleeding from metastasis of pulmonary pleomorphic carcinoma with pembrolizumab.

Hiroaki Ikushima, Reina Asaga, Toshio Sakatani, Yoshio Masuda, Teppei Morikawa, Kazuhiro Usui

Medicine 101(42) e31220 2022年10月21日査読有り筆頭著者責任著者
Multiple cerebral infarctions in ROS1-rearranged lung adenocarcinoma.

Hiroaki Ikushima, Yoshihisa Hiraishi, Kanto Toriumi, Takahiro Ando, Hiroyuki Tamiya, Junichi Ishida, Yosuke Amano, Hidenori Kage, Goh Tanaka, Takahide Nagase

Respirology case reports 9(9) e0831 2021年9月査読有り筆頭著者
Histopathological heterogeneity in an atypical type A thymoma variant with pulmonary metastases.

Masahiro Yanagiya, Hajime Horiuchi, Noriko Hiyama, Jun Matsumoto, Hiroaki Ikushima, Toshio Sakatani, Kei Hara, Teppei Morikawa

Pathology international 71(6) 438-440 2021年6月査読有り
Cisplatin plus pemetrexed therapy and subsequent immune checkpoint inhibitor administration for malignant peritoneal mesothelioma without pleural lesions.

Hiroaki Ikushima, Toshio Sakatani, Sayaka Ohara, Hideyuki Takeshima, Hajime Horiuchi, Teppei Morikawa, Kazuhiro Usui

Medicine 99(22) e19956 2020年5月29日査読有り筆頭著者責任著者
Clinical Features of Patients with an Epidermal Growth Factor Receptor T790M Mutation Detected in Circulating Tumor DNA.

Hiroaki Ikushima, Toshio Sakatani, Kazuhiro Usui

Oncology 98(1) 23-28 2020年査読有り筆頭著者責任著者
Lung spindle cell carcinoma harbouring a constitutively active epidermal growth factor receptor mutation.

Hiroaki Ikushima, Toshio Sakatani, Yoshio Masuda, Teppei Morikawa, Kazuhiro Usui

Respirology case reports 7(2) e00395 2019年2月査読有り筆頭著者責任著者
Successful Treatment of Afatinib-Refractory Non-Small Cell Lung Cancer with Uncommon Complex EGFR Mutations Using Pembrolizumab.

Yuri Taniguchi, Momoko Yamamoto, Hiroaki Ikushima, Sayaka Ohara, Hideyuki Takeshima, Toshio Sakatani, Kazuhiro Usui

Case reports in oncology 12(2) 564-567 2019年査読有り
Severe pleuritis and pericarditis associated with very-late-onset systemic lupus erythematosus.

Hiroaki Ikushima, Akihiko Mitsutake, Takuto Hideyama, Tatsuya Sato, Junko Katsumata, Tomonari Seki, Risa Maekawa, Yukiko Kishida, Yasushi Shiio

Journal of general and family medicine 19(2) 53-56 2018年3月査読有り筆頭著者責任著者
Innate Immune Receptor Signaling and IRF Family of Transcription Factors: Good Deeds and Misdeeds in Oncogenesis

Hiroaki Ikushima, Hideyuki Yanai, Tadatsugu Taniguchi

Inflammation and Immunity in Cancer 85-101 2015年査読有り筆頭著者
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.

Shiho Chiba, Hiroaki Ikushima, Hiroshi Ueki, Hideyuki Yanai, Yoshitaka Kimura, Sho Hangai, Junko Nishio, Hideo Negishi, Tomohiko Tamura, Shinobu Saijo …

eLife 3 e04177 2014年8月22日査読有り筆頭著者
Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.

Hideyuki Yanai, Atsushi Matsuda, Jianbo An, Ryuji Koshiba, Junko Nishio, Hideo Negishi, Hiroaki Ikushima, Takashi Onoe, Hideki Ohdan, Nobuaki Yoshida …

Proceedings of the National Academy of Sciences of the United States of America 110(51) 20699-704 2013年12月17日査読有り
Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis.

Hideo Negishi, Kosuke Matsuki, Nobuyasu Endo, Hana Sarashina, Shoji Miki, Atsushi Matsuda, Keiko Fukazawa, Naoko Taguchi-Atarashi, Hiroaki Ikushima, Hideyuki Yanai …

Proceedings of the National Academy of Sciences of the United States of America 110(49) 19884-9 2013年12月3日査読有り
Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.

Mitsuyoshi Motizuki, Kazunobu Isogaya, Kunio Miyake, Hiroaki Ikushima, Takeo Kubota, Kohei Miyazono, Masao Saitoh, Keiji Miyazawa

The Journal of Biological Chemistry 288(26) 18911-22 2013年6月28日査読有り
TGF-β in cancer stem cells

Hiroaki Ikushima, Kohei Miyazono

TGF-β in Human Disease 9784431544098 93-112 2013年1月1日
The IRF family transcription factors at the interface of innate and adaptive immune responses.

Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi

Cold Spring Harbor symposia on quantitative biology 78 105-16 2013年査読有り筆頭著者
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.

Ryohei Ishii, Kazunobu Isogaya, Azusa Seto, Daizo Koinuma, Yuji Watanabe, Fumio Arisaka, So-ichi Yaguchi, Hiroaki Ikushima, Naoshi Dohmae, Kohei Miyazono …

The EMBO Journal 31(11) 2541-52 2012年5月30日査読有り
TGF-β signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-β.

Hiroaki Ikushima, Kohei Miyazono

Cell and tissue research 347(1) 37-49 2012年1月査読有り筆頭著者
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein.

Hiroaki Ikushima, Tomoki Todo, Yasushi Ino, Masamichi Takahashi, Nobuhito Saito, Keiji Miyazawa, Kohei Miyazono

The Journal of Biological Chemistry 286(48) 41434-41441 2011年12月2日査読有り筆頭著者
Biology of transforming growth factor-β signaling.

Hiroaki Ikushima, Kohei Miyazono

Current pharmaceutical biotechnology 12(12) 2099-107 2011年12月査読有り筆頭著者
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.

Daizo Koinuma, Masahiko Shinozaki, Yoshiko Nagano, Hiroaki Ikushima, Kana Horiguchi, Kouichiro Goto, Tokuhiro Chano, Masao Saitoh, Takeshi Imamura, Kohei Miyazono …

The Journal of Biological Chemistry 286(37) 32502-12 2011年9月16日査読有り
TGFbeta signalling: a complex web in cancer progression.

Hiroaki Ikushima, Kohei Miyazono

Nature Reviews Cancer 10(6) 415-24 2010年6月査読有り筆頭著者
Cellular context-dependent "colors" of transforming growth factor-beta signaling.

Hiroaki Ikushima, Kohei Miyazono

Cancer Science 101(2) 306-12 2010年2月査読有り筆頭著者
Autocrine TGF-beta Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors (vol 5, pg 504, 2009)

Hiroaki Ikushima, Tomoki Todo, Yasushi Ino, Masamichi Takahashi, Keiji Miyazawa, Kohei Miyazono

CELL STEM CELL 5(6) 666-666 2009年12月査読有り筆頭著者
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.

Hiroaki Ikushima, Tomoki Todo, Yasushi Ino, Masamichi Takahashi, Keiji Miyazawa, Kohei Miyazono

Cell Stem Cell 5(5) 504-14 2009年11月6日査読有り筆頭著者
Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator.

Azusa Seto, Hiroaki Ikushima, Toshiyasu Suzuki, Yusuke Sato, Shuya Fukai, Keiko Yuki, Keiji Miyazawa, Kohei Miyazono, Ryuichiro Ishitani, Osamu Nureki

Acta crystallographica. Section F, Structural biology and crystallization communications 65(Pt 1) 21-4 2009年1月1日査読有り
An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling.

Hiroaki Ikushima, Akiyoshi Komuro, Kazunobu Isogaya, Masahiko Shinozaki, Ulf Hellman, Keiji Miyazawa, Kohei Miyazono

The EMBO Journal 27(22) 2955-65 2008年11月19日査読有り筆頭著者