論文

査読有り
2017年10月

Forward and backward evolutionary processes and allele frequency spectrum in a cancer cell population

THEORETICAL POPULATION BIOLOGY
  • Hisashi Ohtsuki
  • ,
  • Hideki Innan

117
開始ページ
43
終了ページ
50
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.tpb.2017.08.006
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

A cancer grows from a single cell, thereby constituting a large cell population. In this work, we are interested in how mutations accumulate in a cancer cell population. We provide a theoretical framework of the stochastic process in a cancer cell population and obtain near exact expressions of allele frequency spectrum or AFS (only continuous approximation is involved) from both forward and backward treatments under a simple setting; all cells undergo cell divisions and die at constant rates, b and d, respectively, such that the entire population grows exponentially. This setting means that once a parental cancer cell is established, in the following growth phase, all mutations are assumed to have no effect on b or d (i.e., neutral or passengers). Our theoretical results show that the difference from organismal population genetics is mainly in the coalescent time scale, and the mutation rate is defined per cell division, not per time unit (e.g., generation). Except for these two factors, the basic logic is very similar between organismal and cancer population genetics, indicating that a number of well established theories of organismal population genetics could be translated to cancer population genetics with simple modifications. (C) 2017 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1016/j.tpb.2017.08.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28866007
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000413176500003&DestApp=WOS_CPL