2011年11月
Investigating the embryo/larval toxic and genotoxic effects of gamma irradiation on zebrafish eggs
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
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- 巻
- 102
- 号
- 11
- 開始ページ
- 1039
- 終了ページ
- 1044
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jenvrad.2011.06.004
- 出版者・発行元
- ELSEVIER SCI LTD
Eggs/larval of freshwater fish (Danio rerio) were exposed to low dose rates of external gamma radiation (from 1 to 1000 mGy d(-1)) over a 20-day period, with the objective of testing the appropriateness of the 10 mGy d(-1) guideline suggested by the IAEA. The present study examines different endpoints, mortality and hatching time and success of embryos as well as the genotoxicity of gamma-irradiations (after 48 h). The 20-day embryo-larval bioassay showed an enhanced larval resistance to starvation after chronic exposure to gamma irradiation (from low 1 mGy d(-1) to high dose rate 1000 mGy d(-1)) and an acceleration in hatching time. Gamma irradiation led to increased genotoxic damage Ito zebrafish egg (40-50% DNA in tail in Comet assay) from the lowest dose rate (1 mGy d(-1)). Possible mechanisms of gamma radiotoxicity and implications for radioprotection are discussed. (C) 2011 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jenvrad.2011.06.004
- ISSN : 0265-931X
- eISSN : 1879-1700
- Web of Science ID : WOS:000295104600009