2018年9月
JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities
GENES TO CELLS
- ,
- ,
- ,
- ,
- ,
- 巻
- 23
- 号
- 9
- 開始ページ
- 767
- 終了ページ
- 777
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/gtc.12627
- 出版者・発行元
- WILEY
Obesity is a serious global health issue; however, the roles of genetics and epigenetics in the onset and progression of obesity are still not completely understood. The aim of this study was to determine the role of Kdm4b, which belongs to a subfamily of histone demethylases, in adipogenesis and fat metabolism in vivo. We established conditional Kdm4b knockout mice. Inactivation of Kdm4b in adipocytes (K4bKO) induced profound obesity in mice on a high fat diet (HFD). The HFD-fed K4bKO mice exhibited an increased volume of fat mass and higher expression levels of adipogenesis-related genes. In contrast, the genes involved in energy expenditure and mitochondrial functions were down-regulated. Supporting these findings, the energy expenditure of Kdm4b-deficient cells was markedly decreased. In addition, progression of glucose intolerance and hepatic steatosis with hepatocellular damages was observed. These data indicate that Kdm4b is a critical regulator of systemic metabolism via enhancing energy expenditure in adipocytes.
- リンク情報
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- DOI
- https://doi.org/10.1111/gtc.12627
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30073721
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000443940900003&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052485193&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85052485193&origin=inward
- ID情報
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- DOI : 10.1111/gtc.12627
- ISSN : 1356-9597
- eISSN : 1365-2443
- PubMed ID : 30073721
- SCOPUS ID : 85052485193
- Web of Science ID : WOS:000443940900003