2018年3月30日
Hippocampal ripples down-regulate synapses.
Science (New York, N.Y.)
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- 巻
- 359
- 号
- 6383
- 開始ページ
- 1524
- 終了ページ
- 1527
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.aao0702
The specific effects of sleep on synaptic plasticity remain unclear. We report that mouse hippocampal sharp-wave ripple oscillations serve as intrinsic events that trigger long-lasting synaptic depression. Silencing of sharp-wave ripples during slow-wave states prevented the spontaneous down-regulation of net synaptic weights and impaired the learning of new memories. The synaptic down-regulation was dependent on the N-methyl-d-aspartate receptor and selective for a specific input pathway. Thus, our findings are consistent with the role of slow-wave states in refining memory engrams by reducing recent memory-irrelevant neuronal activity and suggest a previously unrecognized function for sharp-wave ripples.
- ID情報
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- DOI : 10.1126/science.aao0702
- ISSN : 0036-8075
- PubMed ID : 29439023