論文

査読有り 国際誌
2019年1月

ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness.

Medicine and science in sports and exercise
  • Hiroshi Kumagai
  • ,
  • Eri Miyamoto-Mikami
  • ,
  • Kosuke Hirata
  • ,
  • Naoki Kikuchi
  • ,
  • Nobuhiro Kamiya
  • ,
  • Seigo Hoshikawa
  • ,
  • Hirofumi Zempo
  • ,
  • Hisashi Naito
  • ,
  • Naokazu Miyamoto
  • ,
  • Noriyuki Fuku

51
1
開始ページ
19
終了ページ
26
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1249/MSS.0000000000001750

PURPOSE: Muscle injury is the most common sports injury. Muscle stiffness, a risk factor for muscle injury, is lower in females than in males, implying that sex-related genetic polymorphisms influence muscle injury associated with muscle stiffness. The present study aimed to clarify the associations between two genetic polymorphisms (rs2234693 and rs9340799) in the estrogen receptor 1 gene (ESR1) and muscle injury or muscle stiffness. METHODS: In study 1, a questionnaire was used to assess the muscle injury history of 1311 Japanese top-level athletes. In study 2, stiffness of the hamstring muscles was assessed using ultrasound shear wave elastography in 261 physically active young adults. In both studies, rs2234693 C/T and rs9340799 G/A polymorphisms in the ESR1 were analyzed using the TaqMan SNP Genotyping Assay. RESULTS: In study 1, genotype frequencies for ESR1 rs2234693 C/T were significantly different between the injured and noninjured groups in a C-allele dominant (CC + CT vs TT: odds ratio, 0.62; 95% confidence interval, 0.43-0.91) and additive (CC vs CT vs TT: odds ratio, 0.70; 95% confidence interval, 0.53-0.91) model in all athletes. In study 2, hamstring muscle stiffness was lower in subjects with the CC + CT genotype than in those with the TT genotype; a significant linear trend (CC < CT < TT) was found (r = 0.135, P = 0.029). In contrast, no associations were observed between ESR1 rs9340799 G/A and muscle injury or stiffness. CONCLUSIONS: Our results suggest that the ESR1 rs2234693 C allele, in contrast to the T allele, provides protection against muscle injury by lowering muscle stiffness.

リンク情報
DOI
https://doi.org/10.1249/MSS.0000000000001750
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30113520
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310456
ID情報
  • DOI : 10.1249/MSS.0000000000001750
  • ISSN : 0195-9131
  • PubMed ID : 30113520
  • PubMed Central 記事ID : PMC6310456

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