論文

査読有り 筆頭著者 責任著者
2021年2月5日

Expression of metalloproteinases and their inhibitors in degenerated and extruded intervertebral disks in chondrodystrophic dogs.

The Journal of veterinary medical science
  • Hirokazu Ishino
  • ,
  • Iwao Sakonju

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.20-0317

We analyzed the mRNA expression of matrix metalloproteinases (MMPs), metalloproteinases with thrombospondin motifs (ADAMTSs), and tissue inhibitors of metalloproteinases (TIMPs) in degenerated and herniated intervertebral disks (IVDs) in chondrodystrophic dogs. In degenerated IVDs, MMP3, 7, 13, and 14; ADAMTS4 and 5; and TIMP1-3 expression was significantly higher vs healthy controls (P<0.05). In herniated IVDs, MMP2, 3, 9, 13, and 14; ADAMTS4 and 5; and TIMP1 expression was significantly greater, and MMP7 expression was significantly lower vs degenerated IVDs (P<0.05). These results suggest that metalloproteinase may play a role in extracellular matrix degradation in IVD degeneration. Decreased MMP7 transcription may prevent proteoglycan degradation and reduces macrophage infiltration, which might affect the resorption process of herniated IVDs.

リンク情報
DOI
https://doi.org/10.1292/jvms.20-0317
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33551382
ID情報
  • DOI : 10.1292/jvms.20-0317
  • PubMed ID : 33551382

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