論文

査読有り 筆頭著者 責任著者 国際誌
2019年7月

Hyperadrenocorticism Caused by a Pituitary Ganglioglioma in a Dog.

Veterinary pathology
  • Hirokazu Ishino
  • ,
  • Susumu Takekoshi
  • ,
  • Takahiro Teshima
  • ,
  • Kazuyuki Uchida
  • ,
  • Iwao Sakonju
  • ,
  • Yasushi Hara

56
4
開始ページ
609
終了ページ
613
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0300985819829530

An 11-year-old castrated male Chihuahua dog was presented with complaints of polyuria, polydipsia, abdominal enlargement, and alopecia. Hyperadrenocorticism was diagnosed on the basis of clinical signs, blood tests, adrenocorticotropin-stimulation test results, and an elevated serum adrenocorticotropin concentration. Contrast-enhanced magnetic resonance imaging showed that the pituitary gland was enlarged, compatible with a pituitary macroadenoma. Pituitary-dependent hyperadrenocorticism was suspected, and transsphenoidal hypophysectomy was thus performed for complete resection of the tumor. After surgery, the serum adrenocorticotropin concentration normalized and the hyperadrenocorticism resolved. Histological and immunocytochemical analyses revealed a benign tumor composed of mature neuronal cells and glial cells, suggestive of a ganglioglioma with immunolabeling for adrenocorticotropin. Careful analysis of the resected tumor revealed no pituitary adenoma tissue. The clinical and histopathologic findings indicated that the ganglioglioma was directly responsible for the hyperadrenocorticism. This is the first case of hyperadrenocorticism caused by a ganglioglioma in a dog.

リンク情報
DOI
https://doi.org/10.1177/0300985819829530
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30774022
ID情報
  • DOI : 10.1177/0300985819829530
  • PubMed ID : 30774022

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