1993年3月
CELL-DEPENDENT REQUIREMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIF PROTEIN FOR MATURATION OF VIRUS-PARTICLES
JOURNAL OF VIROLOGY
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- 巻
- 67
- 号
- 3
- 開始ページ
- 1663
- 終了ページ
- 1666
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- AMER SOC MICROBIOLOGY
A highly sensitive single-round infection assay using a bacterial chloramphenicol acetyltransferase was developed to analyze an early stage of human immunodeficiency virus type 1 replication. By a combination of transfection and single-round infection assay, a virus with a vif mutation, depending on host cells from which the virus was derived, was demonstrated to be defective at the early phase of infection cycle. Analysis of viral proteins synthesized in cells indicated that incorporation of the Env surface protein into virions of the vif mutant, again in a cell-dependent way, was greatly restricted. Taken together, it is concluded that the Vif protein acts through modulation of the Env protein in the virions, directly or indirectly, to enhance viral infectivity in a certain cell type.
- リンク情報
- ID情報
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- ISSN : 0022-538X
- PubMed ID : 8437236
- Web of Science ID : WOS:A1993KM61300062