2006年7月
Molecular mechanisms of hyperplasia induction by human papillomavirus E7
ONCOGENE
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- 巻
- 25
- 号
- 30
- 開始ページ
- 4155
- 終了ページ
- 4164
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/sj.onc.1209445
- 出版者・発行元
- NATURE PUBLISHING GROUP
Infections of human papillomavirus (HPV) induce a variety of benign tumors, such as warts and condylomas. During the process of aberrant cell proliferation, genetic mutations are accumulated in the cells, from which malignant tumor cells arise. The viral oncoproteins E6 and E7 are known to help disrupt the cell cycle checkpoint machinery and accelerate chromosomal instability, events which are critical in malignant conversion. However, the mechanisms involved in the hyperplasia caused by HPV infection have remained unknown. We analysed the effects of regulatory genes of HPV18, a typical high-risk-type HPV, on the formation of the epithelial organ by using an organotypic culture system, and found that E7 had potent activity to induce hyperplasia, to which the disruption of the pRb pathway was well correlated. However, analysis with the E7 variants indicated that other pocket proteins are also involved in the activity.
- リンク情報
- ID情報
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- DOI : 10.1038/sj.onc.1209445
- ISSN : 0950-9232
- PubMed ID : 16501608
- Web of Science ID : WOS:000239004800003