Apr, 2015 - Mar, 2017
A new treatment strategy targeting to DNA repair pathway of castration resistant prostate cancer
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
- Grant number
- 15K20108
- Japan Grant Number (JGN)
- JP15K20108
- Grant amount
-
- (Total)
- 3,900,000 Japanese Yen
- (Direct funding)
- 3,000,000 Japanese Yen
- (Indirect funding)
- 900,000 Japanese Yen
In this study, we explored the efficacy of a PARP inhibitor for docetaxel resistant prostate cancer cell line: C4-2AT6. C4-2AT6 cells revealed combined administration of PARP inhibitor and docetaxel had a significant and synergistically high apoptosis inducing effect. In a castrated mice xenograft model, combined PARP inhibitor and docetaxel also showed high anti-tumor effect. These results suggested that inhibition of DNA repair pathway was able to overcome docetaxel resistance in human docetaxel resistant prostate cancer.
- Link information
- ID information
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- Grant number : 15K20108
- Japan Grant Number (JGN) : JP15K20108