MISC

2014年

Size-tunable magnetofluorescent nanoparticles as in vivo imaging

Materials Research Society Symposium Proceedings
  • Keisuke Sato
  • ,
  • Kenji Hirakuri
  • ,
  • Kouki Fujioka
  • ,
  • Yoshinobu Manome
  • ,
  • Hiroaki Sukegawa
  • ,
  • Hideo Iwai
  • ,
  • Naoki Fukata

1660
開始ページ
7
終了ページ
12
記述言語
英語
掲載種別
DOI
10.1557/opl.2014.394
出版者・発行元
Materials Research Society

Magnetic/fluorescent (magnetofluorescent) materials have become one of the most important tools in the imaging modality in vivo using magnetic resonance imaging (MRI) and fluorescence imaging. We succeeded in fabricating magnetofluorescent nanoparticles (MFNPs) consisting of silicon/magnetite composite nanoparticles. Our unique synthetic approach can control simultaneously the magnetic and fluorescence behaviors by varying the particle size, demonstrating the superparamagnetic behavior and green fluorescence for the MFNPs having mean diameter of 3.0 nm, and the ferromagnetic behavior without fluorescence for the MFNPs having mean diameter more than 5.0 nm. More intriguingly, the MFNPs with superparamagnetism can detect green fluorescence even after the magnetic guidance of MFNPs by the commercial neodymium magnet. Additionally, the MFNPs having two magnetic behaviors also possess good biocompatibility.

リンク情報
DOI
https://doi.org/10.1557/opl.2014.394
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939177450&origin=inward

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