Hironori Edamatsu

Profile Information

Affiliation: Faculty of Medicine, Juntendo University

Degree: 博士（理学）(Mar, 1999, 東京工業大学)

Researcher number: 70335438
ORCID ID: https://orcid.org/0000-0002-1335-4217
J-GLOBAL ID: 200901007773558321
researchmap Member ID: 1000275641

Research Areas

Life sciences / Pathobiochemistry /

Research History

Apr, 2023 - Present

Juntendo University
Apr, 2021 - Present

Juntendo University
Apr, 2020 - Mar, 2023

Juntendo University
Apr, 2016 - Mar, 2020

Graduate School of Medicine, Kobe University
Apr, 2007 - Mar, 2016

神戸大学大学院医学研究科助教
Apr, 2001 - Mar, 2007

Graduate School of Medicine, Kobe University
Feb, 2001 - Mar, 2001

School of Medicine, Kobe University
May, 1999 - Jan, 2001

Postdoctoral researcher, Department of Microbiology and Molecular Genetics, University of California, Los Angeles

Education

- Mar, 1999

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
- Mar, 1994

Tokyo Institute of Technology

Papers

Zinc ions negatively regulate proapoptotic signaling in cells expressing oncogenic mutant Ras

Hironori Edamatsu

BioMetals, 35(2) 349-362, Feb 25, 2022 Peer-reviewedLead authorCorresponding author
Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E. Bilasy, Tsuyoshi Miyakawa, Tohru Kataoka

Molecular Brain, 11(1) 27, May 10, 2018 Peer-reviewed
ブレオマイシン誘導肺線維症マウスモデルにおけるPLCεの役割

桂田雅大, 永野達也, 枝松裕紀, 梅澤佳乃子, 堂國良太, 安田裕一郎, 山本正嗣, 小林和幸, 片岡徹, 西村善博

日本呼吸器学会誌, 7(増刊) 231-231, Mar, 2018
Structural basis for intramolecular interaction of post-translationally modified H-Ras.GTP prepared by protein ligation

Haoliang Ke, Shigeyuki Matsumoto, Yosuke Murashima, Haruka Taniguchi-Tamura, Ryo Miyamoto, Yoko Yoshikawa, Chiemi Tsuda, Takashi Kumasaka, Eiichi Mizohata, Hironori Edamatsu …

FEBS LETTERS, 591(16) 2470-2481, Aug, 2017 Peer-reviewed
Phospholipase C epsilon Activates Nuclear Factor-kappa B Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor kappa B in Colon Epithelial Cells

Masahiro Wakita, Hironori Edamatsu, Mingzhen Li, Aki Emi, Sohei Kitazawa, Tohru Kataoka

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(24) 12586-12600, Jun, 2016 Peer-reviewed
Crucial role of Rapgef2 and Rapgef6, a family of guanine nucleotide exchange factors for Rap1 small GTPase, in formation of apical surface adherens junctions and neural progenitor development in the mouse cerebral cortex

Kazuhiro Maeta, Hironori Edamatsu, Kaori Nishihara, Junji Ikutomo, Shymaa E. Bilasy, Tohru Kataoka

eNeuro, 3(3) 1994-2008, 2016 Peer-reviewed
Phospholipase C epsilon, an Effector of Ras and Rap Small GTPases, Is Required for Airway Inflammatory Response in a Mouse Model of Bronchial Asthma

Tatsuya Nagano, Hironori Edamatsu, Kazuyuki Kobayashi, Nobuyuki Takenaka, Masatsugu Yamamoto, Naoto Sasaki, Yoshihiro Nishimura, Tohru Kataoka

PLOS ONE, 9(9) e108373, Sep, 2014 Peer-reviewed
Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis

Keisuke Okada, Hideaki Miyake, Kohei Yamaguchi, Koji Chiba, Kazuhiro Maeta, Shymaa E. Bilasy, Hironori Edamatsu, Tohru Kataoka, Masato Fujisawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 445(1) 89-94, Feb, 2014 Peer-reviewed
RA-GEF-2(Rapgef6)のマウス精子形成における役割

岡田桂輔, 山口耕平, 福田輝雄, 江夏徳寿, 李福平, 松下経, 千葉公嗣, 三宅秀明, 前田和宏, Bilasy Shymaa E. …

日本生殖医学会雑誌, 58(4) 371-371, Oct, 2013
マウス精子形成におけるRA-GEF-2の機能解析

岡田桂輔, 山口耕平, 江夏徳寿, 李福平, 松下経, 千葉公嗣, 三宅秀明, 前田和宏, Bilasy Shymaa E., 枝松裕紀 …

日本泌尿器科学会雑誌, 104(2) 474-474, Mar, 2013
マウス精子形成におけるRA-GEF-2のノックアウトマウスを用いた機能解析

Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato, Maeda Kazuhiro, EL-SHAWADFYMOHAMED BILASY SHYMAA, Edamatsu Hironori, Kataoka Tohru

日本生殖医学会雑誌, 57(4号) 327-327, Oct, 2012
マウス精子形成におけるRA-GEF-2のノックアウトマウスを用いた機能解析

Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato, Maeda Kazuhiro, EL-SHAWADFYMOHAMED BILASY SHYMAA, Edamatsu Hironori, Kataoka Tohru

日本内分泌学会雑誌, 88(2号) 735-735, Sep, 2012
PLC epsilon cooperates with the NF-kappa B pathway to augment TNF alpha-stimulated CCL2/MCP1 expression in human keratinocyte

Yuko Harada, Hironori Edamatsu, Tohru Kataoka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 414(1) 106-111, Oct, 2011 Peer-reviewed
Phospholipase C epsilon has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC

Masahiro Oka, Hironori Edamatsu, Makoto Kunisada, Lizhi Hu, Nobuyuki Takenaka, Masanobu Sakaguchi, Tohru Kataoka, Chikako Nishigori

LABORATORY INVESTIGATION, 91(5) 711-718, May, 2011 Peer-reviewed
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5

Takahiko Kobayashi, Junich Ishida, Manabu Musashi, Shuichi Ota, Takeshi Yoshida, Yuichi Shimizu, Makoto Chuma, Hiroshi Kawakami, Masahiro Asaka, Junji Tanaka …

INTERNATIONAL JOURNAL OF CANCER, 128(2) 304-318, Jan, 2011
Overexpression of phospholipase C epsilon in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration

Nobuyuki Takenaka, Hironori Edamatsu, Noboru Suzuki, Hiromitsu Saito, Yukiko Inoue, Masahiro Oka, Lizhi Hu, Tohru Kataoka

EUROPEAN JOURNAL OF IMMUNOLOGY, 41(1) 202-213, Jan, 2011
Enhancement of ultraviolet B-induced skin tumor development in phospholipase C epsilon-knockout mice is associated with decreased cell death

Masahiro Oka, Hironori Edamatsu, Makoto Kunisada, Lizhi Hu, Nobuyuki Takenaka, Siphora Dien, Masanobu Sakaguchi, Riko Kitazawa, Kazumi Norose, Tohru Kataoka …

CARCINOGENESIS, 31(10) 1897-1902, Oct, 2010
Crucial Role of Phospholipase C epsilon in Induction of Local Skin Inflammatory Reactions in the Elicitation Stage of Allergic Contact Hypersensitivity

Lizhi Hu, Hironori Edamatsu, Nobuyuki Takenaka, Shuzo Ikuta, Tohru Kataoka

JOURNAL OF IMMUNOLOGY, 184(2) 993-1002, Jan, 2010
Phospholipase C epsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis

Mingzhen Li, Hironori Edamatsu, Riko Kitazawa, Sohei Kitazawa, Tohru Kataoka

CARCINOGENESIS, 30(8) 1424-1432, Aug, 2009 Peer-reviewed
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester

Shuzo Ikuta, Hironori Edamatsu, Mingzhen Li, Lizhi Hu, Tohru Kataoka

CANCER RESEARCH, 68(1) 64-72, Jan, 2008 Peer-reviewed

Misc.

LOSS OF RA-GEF-2 (RAPGEF6) IN MOUSE CAUSES ALTERED LOCALIZATION OF N-CADHERIN AND CAN CAUSE MALE INFERTILITY

Keisuke Okada, Koji Chiba, Teruo Fukuda, Noritoshi Enatsu, Kei Matsushita, Hideaki Miyake, Kazuhiro Maeta, Hironori Edamatsu, Toru Kataoka, Masato Fujisawa

JOURNAL OF UROLOGY, 191(4) E741-E741, Apr, 2014
Crucial Role Of Phospholipase C epsilon In T Helper Type 2 Cell Mediated Airway Inflammation In Mice

T. Nagano, H. Edamatsu, K. Kobayashi, Y. Nishimura, T. Kataoka

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 189, 2014
Phospholipase Cε as a potential molecular target for anti-inflammatory therapy and cancer prevention

Edamatsu Hironori, Kataoka Tohru

Inflammation and regeneration., Vol. 31, No. 4, pp. 370-374, Sep, 2011 Peer-reviewed
OVEREXPRESSION OF PHOSPHOLIPASE C EPSILON IN KERATINOCYTES RESULTS IN IL-23 PRODUCTION LEADING TO SKIN INFLAMMATION ACCOMPANIED BY IL-22-PRODUCING T CELL INFILTRATION

H. Edamatsu, N. Takenaka, T. Kataoka

INFLAMMATION RESEARCH, 60 61-61, Jun, 2011
ホスホリパーゼCεは炎症と血管形成の増大を通してApcMinマウスの腸腫瘍形成を促進する

枝松裕紀, 李明珍, 北澤理子, 北澤荘平, 片岡徹

日本生化学会大会プログラム・講演要旨集, 82回 4T8p-3, Sep, 2009
PLCεによる小腸腺腫における腫瘍細胞の増殖と生存の制御(Regulation of tumor cell proliferation and survival in intestinal tumorigenesis by PLCε)

李明珍, 枝松裕紀, 北澤荘平, 片岡徹

日本癌学会総会記事, 67回 397-397, Sep, 2008
Phospholipase C epsilon plays a crucial role in ultraviolet B-induced skin inflammation

M. Oka, T. Kamo, H. Edamatsu, M. Sakaguchi, M. Kunisada, T. Kataoka, C. Nishgori

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128 S206-S206, Apr, 2008
Apc1Min誘導性発癌におけるRas/RapエフェクターのホスホリパーゼCepsilonの関与(Involvement of the Ras/Rap effector, phospholipase Cepsilon, in Apc1Min-induced tumorigenesis)

李明珍, 枝松裕紀, 北澤荘平, 片岡徹

日本癌学会総会記事, 66回 83-83, Aug, 2007
Phospholipase Cepsilon guanine nucleotide exchange factor activity and activation of Rap1.

Hironori Edamatsu

Methods in enzymology, Vol. 407, No. -, pp. 281-290, Jan 1, 2006
Phospholipase Cepsilon guanine nucleotide exchange factor activity and activation of Rap1

SATOH, Takaya, EDAMATSU, Hironori, KATAOKA, Toru

Methods In Enzymology, none, 2005
Genetic ablation of phospholipase C-epsilon resulted in defective cardiac semilunar valve formation

S Minamisawa, M Tadano, H Edamatsu, U Yokoyama, Y Ishikawa, N Suzuki, H Saito, T Satoh, T Kataoka

CIRCULATION, 110(17) 93-93, Oct, 2004
PLCepsilonはマウス正常大動脈弁形成に必須である

南沢享, 多々野誠, 枝松裕紀, 横山詩子, 石川義弘, 片岡徹

日本小児循環器学会雑誌, 20(3) 267-267, May, 2004
Differential display of mRNAs regulated by G-protein signaling

H Edamatsu, Y Kaziro, H Itoh

G PROTEIN PATHWAYS: PT C, EFFECTOR MECHANISMS, 345 521-529, 2002
Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines

EDAMATSU H.

Oncogene, 19 3059-3068, 2000
Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-gamma-induced MAPK activation that is mediated by p21(ras)

T Nishiya, T Uehara, H Edamatsu, Y Kaziro, H Itoh, Y Nomura

FEBS LETTERS, 408(1) 33-38, May, 1997

Books and Other Publications

次世代がん戦略研究Update がん基盤生物学革新的シーズ育成に向けて / がん微小環境を制御するRas/Rap標的タンパク質PLCεの選択的阻害剤の開発

Edamatsu Hironori, Kataoka Tohru

南山堂, Oct, 2013
デブリン生化学-臨床の理解のために原著7版 / 第7章組換えDNAとバイオテクノロジー

Edamatsu Hironori (Role: Joint translator)

丸善出版, Dec, 2012
シグナル伝達生命システムの情報ネットワーク第2版 / シグナル伝達第2版

Edamatsu Hironori (Role: Joint translator)

メディカル・サイエンス・インターナショナル, Dec, 2011
シグナル伝達生命システムの情報ネットワーク / 第7章カルシウムとシグナル伝達、第8章カルシウムシグナリング

上代淑人, SATOH, Takaya, 水谷伸, EDAMATSU, Hironori, 清野真理, 北村俊雄, 小出寛 (Role: Joint translator)

メディカル・サイエンス・インターナショナル, May, 2004
シグナル伝達生命システムの情報ネットワーク / 2章第一メッセンジャー、3章受容体、4章GTP結合タンパク質とシグナル伝達

上代淑人, SATOH, Takaya, 水谷伸, EDAMATSU, Hironori, 清野真理, 北村俊雄, 小出寛 (Role: Joint translator)

メディカル・サイエンス・インターナショナル, May, 2004

Presentations

rasシグナルによる亜鉛依存的ストレス応答に関連した遺伝子の網羅的発現解析

EDAMATSU HIRONORI

第18回日本亜鉛栄養治療研究会, Feb, 2019, 日本亜鉛栄養治療研究会
活性型変異体Hras発現細胞における亜鉛依存的遺伝子発現の解析

EDAMATSU HIRONORI

第41回日本分子生物学会年会, Nov, 2018, 日本分子生物学会
ブレオマイシン誘導肺線維症マウスモデルにおけるPLCεの役割

桂田雅大, NAGANO TATSUYA, EDAMATSU HIRONORI, UMEZAWA KANOKO, 堂國良太, 安田裕一郎, YAMAMOTO MASATSUGU, KOBAYASHI KAZUYUKI, KATAOKA TOHRU, NISHIMURA YOSHIHIRO

第58回日本呼吸器学会学術講演会, Apr, 2018
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε（ポスター発表）

Yoshikawa Yoko, Naoto Fujishima, Aki Emi, Ning Ma, Masayuki Isa, Edamatsu Hironori, Kataoka Tohru

2018 Keystone Symposia Conference, Feb, 2018, Keystone Symposia on Molecular and Cellular Biology
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε

Yoshikawa Yoko, Naoto Fujishima, Aki Emi, Ning Ma, Masayuki Isa, Edamatsu Hironori, Kataoka Tohru

2018 Keystone Symposia Conference, Feb, 2018
Structural basis for the intramolecular interaction to assemble the c-Raf-1 recognition site in posttranslationally modified H-Ras•GTP

Matsumoto Shigeyuki, 柯浩亮, 村嶋陽亮, Taniguchi Haruka, 宮本涼生, Yoshikawa Yoko, 津田智恵美, 熊坂崇, 溝端栄一, Edamatsu Hironori, Kataoka Tohru

2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会第90回日本生化学会大会）, Dec, 2017
Anti-Cancer and anti-inflammatory effect of specific inhibitors for Phospholipase Ce (PLCe)

藤島尚人, Yoshikawa Yoko, 衣斐亜希, 馬寧, 伊佐真幸, Edamatsu Hironori, Kataoka Tohru

2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会第90回日本生化学会大会）, Dec, 2017
A mouse model of acute lung injury implicates phospholipase Ce in neutrophilic inflammation through CXC chemokine production

Kanoko Umezawa, Nagano Tatsuya, Edamatsu Hironori, Haruka Nshimura, Daisuke Tamura, Kobayashi Kazuyuki, Kataoka Tohru, Nishimura Yoshihiro

ERS International Congress 2016, Sep, 2016
Sotase Aを利用した翻訳後脂質修飾型Rasの産生と構造物学研究

村嶋陽亮, 柯浩亮, Matsumoto Shigeyuki, Edamatsu Hironori, Kataoka Tohru

第14回次世代を担う若手のためのフィジカル・ファーマフォーラム, Aug, 2016
ピルビン酸キナーゼM2のリン酸化とアセチル化へのRasシグナル伝達系の影響

Edamatsu Hironori, Kataoka Tohru

第38回日本分子生物学会年会, Dec, 2015
Rap1活性化因子であるRapgef2の大脳皮質発生過程における脳室面の接着構造(接着帯）の制御における役割

Maeta Kazuhiro, Edamatsu Hironori, Kataoka Tohru

第38回日本分子生物学会年会, Dec, 2015
Role of Phospholipase Cε (PLCε) in Inflammation and Tumorigenesis

Edamatsu Hironori

University of Washington-Kobe University Joint Symposium on Cell Signaling, Sep, 2015, University of Washington and Kobe University Invited
マウス胎生期大脳皮質の放射状グリア細胞の局在決定におけるRap1活性化因子Rapgef2の重要な役割

Maeta Kazuhiro, Edamatsu Hironori, Kataoka Tohru

第37回日本分子生物学会年会, Nov, 2014, 日本分子生物学会
ホスホリパーゼCεを介したサイトカイン産生制御機構の解明

脇田将裕, Edamatsu Hironori, Kataoka Tohru

第37回日本分子生物学会年会, Nov, 2014, 日本分子生物学会
Rasにより活性化される細胞内シグナル伝達系制御への代謝産物と金属イオンの関与

Edamatsu Hironori, Kataoka Tohru

第37回日本分子生物学会年会, Nov, 2014, 日本分子生物学会
Crucial role of phospholipase Cε in T helper type 2 cell-mediated airway inflammation in mice.

Nagano, T, Edamatsu Hironori, Kobayashi Kazuyuki, Nishimura Yoshihiro, Kataoka Tohru

ATS2014, May, 2014, American Thoracic Society
低分子量G蛋白質Rap1の活性化因子RA-GEF-1、RA-GEF-2はマウス胎児の大脳皮質の頂端部において細胞接着の維持に関与する

生友淳嗣, Maeda Kazuhiro, Edamatsu Hironori, Kataoka Tohru

第36回日本分子生物学会年会, Dec, 2013, 日本分子生物学会
RA‐GEF‐2(Rapgef6)のマウス精子形成における役割

岡田桂輔, Yamaguchi Kohei, 福田輝雄, 江夏徳寿, 李福平, Matsushita Kei, Chiba Koji, Miyake Hideaki, Maeda Kazuhiro, Shymaa E.Bilasy, Edamatsu Hironori, Kataoka Tohru, Fujisawa Masato

第58回日本生殖医学会学術講演会・総会, Nov, 2013, 日本生殖医学会学術講演会・総会
Crucial role of Rapgef2 and Rapgef6 in the proper development and distribution of neural progenitor cells in mouse brain

Kataoka Tohru, Maeda Kazuhiro, Edamatsu Hironori, 生友淳嗣

第86回日本生化学会大会, Sep, 2013, 日本生化学会
The Rap1 guanine nucleotide exchange factors, RA-GEF-1 and RA-GEF-2, are required for the proper distribution of neural progenitors in mice

Maeda Kazuhiro, 西原香, 藤川千恵, 坪谷一樹, Edamatsu Hironori, Kataoka Tohru

Neuro2013（第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会）, Jun, 2013, 日本神経科学会・日本神経化学会・日本神経回路学会

Teaching Experience

Oct, 2021 - Present

細胞の生物学 (順天堂大学)
Apr, 2020 - Present

自然科学総合実習 (順天堂大学)
Apr, 2020 - Present

Cell Biology (Juntendo University)
- Mar, 2020

生理学 (神戸大学)
- Mar, 2020

Physiology (Kobe University)

Research Projects

自然科学系の実験実習はどこまでデジタルコンテンツ化できるのか、そのノウハウの探求

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

松本顕, 石原量, 和田麻理, 矢田雅哉, 枝松裕紀
Regulation of oncogenic RAS-induced endoplasmic reticulum stress response by zinc signaling

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
亜鉛欠乏症への亜鉛要求性タンパク質恒常性維持シグナル伝達機構破綻の関与

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2023

枝松裕紀
Structural study on the role of post-translational lipid modifications of the small G protein Ras

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

KATAOKA TOHRU
Role of inflammation and phospholipase Cepsilon in tumor development

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

EDAMATSU Hironori
Elucidation of a novel signaling pathway responsible for the roles of phospholipase Cepsilon in augmentation of inflammation and carcinogenesis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

KATAOKA TOHRU, SHIMA Fumi, EDAMATSU Hironori
Role of phospholipase C epsilon in ultraviolet-induced skin carcinogenesis, skin inflammation, cataract, and psoriasis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

OKA Masahiro, EDAMATSU Hironori
Study of the mechanism by which phospholipase C・regulates T-cell-mediated inflammation

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

EDAMATSU Hironori
Analysis of the function of Rap1-activating factors which mediate the cross-talks between different species of small G proteins

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

KATAOKA Tohru, SATOH Takaya, SHIMA FUMI, EDAMATSU Hironori, HIRASHIMA Masanori
Study of the mechanism by which phospholipase C・ regulates proinflammatory cytokine production

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2008 - 2009

EDAMATSU Hironori
Mechanism of cell growth regulation by small G proteins

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

KATAOKA Tohru, SHIMA Fumi, EDAMATSU Hironori
Ras標的蛋白質ホスホリパーゼCεが制御する癌化シグナルの解明

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2006 - 2007

枝松裕紀
Elucidation of the in vivo function of the Ras/Rap effector phospholipase Cε

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2006

KATAOKA Tohru, SATOH Takaya, SHIMA Fumi, EDAMATSU Hironori
細胞の癌化におけるRas標的蛋白質PLCεの役割

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2004 - 2005

枝松裕紀
Analysis of the Regulatory Mechanism and Function of a Novel Class of Phospholipase C, PLCε

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2004

KATAOKA Tohru, SATOH Takaya, SHIMA Fumi, EDAMATSU Hironori
低分子量G蛋白質による細胞増殖の制御機構

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2000 - 2004

片岡徹, 島扶美, 枝松裕紀, 苅谷研一
Analysis of the Function of a Novel Class of Mammalian Phospholipase C, PLCε

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2002

KATAOKA Tohru, EDAMATSU Hironori, SHIMA Fumi, SATOH Takaya

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