論文

国際誌
2016年

Analysis of Epileptic Discharges from Implanted Subdural Electrodes in Patients with Sturge-Weber Syndrome.

PloS one
  • Yasushi Iimura
  • ,
  • Hidenori Sugano
  • ,
  • Madoka Nakajima
  • ,
  • Takuma Higo
  • ,
  • Hiroharu Suzuki
  • ,
  • Hajime Nakanishi
  • ,
  • Hajime Arai

11
4
開始ページ
e0152992
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0152992
出版者・発行元
PUBLIC LIBRARY SCIENCE

OBJECTIVE: Almost two-thirds of patients with Sturge-Weber syndrome (SWS) have epilepsy, and half of them require surgery for it. However, it is well known that scalp electroencephalography (EEG) does not demonstrate unequivocal epileptic discharges in patients with SWS. Therefore, we analyzed interictal and ictal discharges from intracranial subdural EEG recordings in patients treated surgically for SWS to elucidate epileptogenicity in this disorder. METHODS: Five intractable epileptic patients with SWS who were implanted with subdural electrodes for presurgical evaluation were enrolled in this study. We examined the following seizure parameters: seizure onset zone (SOZ), propagation speed of seizure discharges, and seizure duration by visual inspection. Additionally, power spectrogram analysis on some frequency bands at SOZ was performed from 60 s before the visually detected seizure onset using the EEG Complex Demodulation Method (CDM). RESULTS: We obtained 21 seizures from five patients for evaluation, and all seizures initiated from the cortex under the leptomeningeal angioma. Most of the patients presented with motionless staring and respiratory distress as seizure symptoms. The average seizure propagation speed and duration were 3.1 ± 3.6 cm/min and 19.4 ± 33.6 min, respectively. Significant power spectrogram changes at the SOZ were detected at 10-30 Hz from 15 s before seizure onset, and at 30-80 Hz from 5 s before seizure onset. SIGNIFICANCE: In patients with SWS, seizures initiate from the cortex under the leptomeningeal angioma, and seizure propagation is slow and persists for a longer period. CDM indicated beta to low gamma-ranged seizure discharges starting from shortly before the visually detected seizure onset. Our ECoG findings indicate that ischemia is a principal mechanism underlying ictogenesis and epileptogenesis in SWS.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0152992
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27054715
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824532
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000373608000061&DestApp=WOS_CPL
ID情報
  • DOI : 10.1371/journal.pone.0152992
  • ISSN : 1932-6203
  • PubMed ID : 27054715
  • PubMed Central 記事ID : PMC4824532
  • Web of Science ID : WOS:000373608000061

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