Hirokazu Kashiwagi

Profile Information

Affiliation: Osaka University

J-GLOBAL ID: 201801003861705614
researchmap Member ID: B000306377

Research Areas

Life sciences / Hematology and oncology /

Research History

Apr, 2021 - Present

Director, Hospital, Department of Blood Transfusion, Osaka University
Apr, 2021 - Present

Associate Professor, Osaka University Hospital
Apr, 2012 - Mar, 2021

Associate Professor, Osaka University Graduate School of Medicine Division of Medicine
Oct, 2010 - Mar, 2012

Assistant Professor, Osaka University Graduate School of Medicine Division of Medicine
Apr, 2007 - Sep, 2010

Assistant Professor, Osaka University Division of Internal Medicine
Apr, 2006 - Mar, 2007

Research Assistant, Osaka University Division of Internal Medicine

Education

- Mar, 1986

Faculty of Medicine, Osaka University

Papers

105

Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition

Hirokazu Kashiwagi, Masataka Kuwana, Mitsuru Murata, Naoki Shimada, Toshiro Takafuta, Jun Yamanouchi, Hisashi Kato, Takaaki Hato, Yoshiaki Tomiyama

International Journal of Hematology, Nov 13, 2023
非活性化変異β3(R734C)ノックインマウスは血小板機能異常を伴う巨大血小板性血小板減少症を呈する

中田継一, 芥田敬吾, 小池翠, 加藤恒, 冨山佳昭, 保仙直毅, 柏木浩和

日本血液学会学術集会, 85回 304-304, Oct, 2023
成人免疫性血小板減少症診断参照ガイド2023年版

柏木浩和, 桑名正隆, 村田満, 島田直毅, 高蓋寿朗, 山之内純, 加藤恒, 羽藤高明, 冨山佳昭, 厚生労働省難治性疾患政策研究事業血液凝固異常症等に関する研究班「ITP診断参照ガイド」作成委員会

臨床血液, 64(10) 1245-1257, Oct, 2023
FNAIT pathogenesis determined by serial analysis of three subsequent pregnancies of a woman with severe fetal and neonatal alloimmune thrombocytopenia (FNAIT) with anti-HPA-4b and anti-HPA-5b alloantibodies in the first sibling.

Tomoko Kiyokawa, Kazuya Mimura, Keisuke Nagamine, Kotarosumitomo Nakayama, Mikiko Horiuchi, Tamayo Morikawa, Mika Hosokawa, Mayumi Nakao, Masayuki Endo, Tadashi Kimura …

International journal of hematology, 118(1) 146-150, Jul, 2023
インテグリンαIIbβ3非活性化変異β3(R734C)ノックインマウスは巨大血小板性血小板減少症を示す

中田継一, 芥田敬吾, 小池翠, 加藤恒, 保仙直毅, 柏木浩和

日本血栓止血学会誌, 34(2) 255-255, May, 2023
[Acquired hemophilia A following BNT162b2 mRNA COVID-19 vaccination].

Ayami Senda, Hideaki Saito, Shinsuke Kusakabe, Koki Yoshida, Kumi Shibata, Shuhei Kida, Jun Toda, Akihisa Hino, Tomoaki Ueda, Jiro Fujita …

[Rinsho ketsueki] The Japanese journal of clinical hematology, 64(1) 35-41, 2023
多発性骨髄腫患者に対する抗CD38モノクローナル抗体製剤投与が直接抗グロブリン試験に与える影響

細川美香, 永峰啓丞, 青地寛, 中山小太郎純友, 櫻木美基子, 森川珠世, 中尾まゆみ, 清川知子, 加藤恒, 冨山佳昭 …

日本輸血細胞治療学会誌, 68(3) 412-421, Jun, 2022
硝子体出血の止血管理が困難であったGlanzmann血小板無力症の一例

小池翠, 加藤恒, 中田継一, 保仙直毅, 柏木浩和

日本血栓止血学会誌, 33(2) 262-262, May, 2022
同種造血幹細胞移植後ITPの診断における網状血小板比率、抗血小板自己抗体測定の意義

芥田敬吾, 福島健太郎, 中田継一, 林悟, 堤一仁, 日野彬央, 戸田淳, 草壁信輔, 上田智朗, 藤田二郎 …

日本血栓止血学会誌, 33(2) 288-288, May, 2022
Increased cleavage of von Willebrand factor by ADAMTS13 may contribute strongly to acquired von Willebrand syndrome development in patients with essential thrombocythemia.

Masayuki Kubo, Kazuya Sakai, Masaki Hayakawa, Hirokazu Kashiwagi, Hideo Yagi, Yoshinobu Seki, Atsushi Hasegawa, Haruyuki Tanaka, Itsuto Amano, Yoshiaki Tomiyama …

Journal of thrombosis and haemostasis : JTH, Mar 30, 2022 Peer-reviewed
Autoimmune-mediated thrombocytopenia after allogeneic hematopoietic stem cell transplantation: significance of detecting reticulated platelets and glycoprotein-specific platelet autoantibodies.

Keigo Akuta, Kentaro Fukushima, Keiichi Nakata, Satoru Hayashi, Jun Toda, Yasuhiro Shingai, Kazuhito Tsutsumi, Tomohisa Machida, Akihisa Hino, Shinsuke Kusakabe …

International journal of hematology, 115(3) 322-328, Mar, 2022 Peer-reviewedCorresponding author
当院における輸血直前入力漏れ0(ゼロ)に向けた取り組み手術支援システム改造と多職種連携

中尾まゆみ, 青地寛, 中山小太郎純友, 細川美香, 櫻木美基子, 森川珠世, 清川知子, 永峰啓丞, 加藤恒, 柏木浩和 …

日本輸血細胞治療学会誌, 68(1) 28-33, Feb, 2022
Development of an Automated Chemiluminescent Enzyme Immunoassay for Measuring Thrombopoietin in Human Plasma.

Yukihiro Nishikawa, Shiyo Nishida, Keiko Kuroda, Hirokazu Kashiwagi, Yoshiaki Tomiyama, Masataka Kuwana

Diagnostics (Basel, Switzerland), 12(2), Jan 26, 2022 Peer-reviewed
輸血副作用とHLA抗体 in 造血器腫瘍学(第 2 版) ―基礎と臨床の最新研究動向―

柏木浩和

日本臨牀 78 巻増刊号 3, 78(3) 267-272, Aug, 2020 InvitedLead authorCorresponding author
II. Pathophysiology and Treatment of Primary Immune Thrombocytopenia

Hirokazu Kashiwagi

Nihon Naika Gakkai Zasshi, 109(7) 1347-1354, Jul 10, 2020 InvitedLead authorCorresponding author
Reevaluation of platelet function in chronic immune thrombocytopenia: impacts of platelet size, platelet-associated anti-αIIbβ3 antibodies and thrombopoietin receptor agonists.

Nobuko Nishiura, Hirokazu Kashiwagi, Keigo Akuta, Satoru Hayashi, Hisashi Kato, Yuzuru Kanakura, Yoshiaki Tomiyama

British journal of haematology, 189(4) 760-771, May, 2020 Peer-reviewedCorresponding author
Risk factors for skin, mucosal, and organ bleeding in adults with primary ITP: a nationwide study in Japan.

Takaaki Hato, Naoki Shimada, Yoshiyuki Kurata, Masataka Kuwana, Kingo Fujimura, Hirokazu Kashiwagi, Toshiro Takafuta, Mitsuru Murata, Yoshiaki Tomiyama

Blood advances, 4(8) 1648-1655, Apr 28, 2020 Peer-reviewed
Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision.

Hirokazu Kashiwagi, Masataka Kuwana, Takaaki Hato, Toshiro Takafuta, Kingo Fujimura, Yoshiyuki Kurata, Mitsuru Murata, Yoshiaki Tomiyama

International journal of hematology, 111(3) 329-351, Mar, 2020 Peer-reviewedLead author
Knock-in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction.

Keigo Akuta, Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, Nobuko Nishiura, Fumiaki Banno, Koichi Kokame, Hisashi Kato, Yuzuru Kanakura, Toshiyuki Miyata …

Journal of thrombosis and haemostasis : JTH, 18(2) 497-509, Feb, 2020 Peer-reviewedCorresponding author
Secondary immune thrombocytopenic purpura with renal cell carcinoma.

Shigeaki Nakazawa, Masataka Kawamura, Kosuke Nakano, Norichika Ueda, Hidefumi Kishikawa, Hirokazu Kashiwagi, Motohide Uemura, Ryoichi Imamura, Kenji Nishimura, Norio Nonomura

IJU case reports, 2(5) 250-252, Sep, 2019 Peer-reviewed

Misc.

硝子体出血の止血管理が困難であったGlanzmann血小板無力症の一例

小池翠, 加藤恒, 中田継一, 保仙直毅, 柏木浩和

日本血栓止血学会誌, 33(2) 262-262, May, 2022
Reference guide for management of adult idiopathic thrombocytopenic purpura (ITP): 2019 version

KASHIWAGI Hirokazu

Rinsho Ketsueki, 60(8) 877-896, Aug, 2019 Lead author
後天性血小板機能異常症

柏木浩和

日本血栓止血学会誌, 29(6) 620‐624(J‐STAGE), Dec, 2018 Invited
alpha IIb(R990W), a Gain-of Function Mutation of alpha IIb beta 3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Keigo Akuta, Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, Shigenori Honda, Yuzuru Kanakura …

BLOOD, 132, Nov, 2018
Platelet Integrin alpha IIb beta 3 Activation Kinetics in Inherited Platelet Functional Disorders similar to the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 alpha IIb beta 3 Activation By inside-out Signaling

Hisashi Kato, Nobuko Nishiura, Keigo Akuta, Hirokazu Kashiwagi, Koichi Kokame, Toshiyuki Miyata, Yuzuru Kanakura, Yoshiaki Tomiyama

BLOOD, 132, Nov, 2018
患者さんからよく尋ねられる内科診療のFAQ 第8章血液どれくらいまでなら運動してもいいですか?[28歳女性,慢性特発性血小板減少性紫斑病]

柏木浩和

内科, 120(3) 734‐736, Sep, 2017
やさしく考える抗血栓薬・止血薬こんなとき,どうする?2)出血症状が出たときはどうする?

柏木浩和

レジデントノート, 19(7) 1212‐1218-1218, Aug 1, 2017
出血症状が出たときはどうする? (特集やさしく考える抗血栓薬・止血薬 : 凝固・線溶の基本から、病態ごとの使い分けまで) -- (こんなとき,どうする?)

柏木浩和

レジデントノート, 19(7) 1212-1218, Aug, 2017
動脈・静脈疾患の基礎研究動向血小板機能と抗血小板薬

柏木浩和

日本臨床, 75 1055‐1061, Jul 20, 2017 Lead author
中鎖脂肪酸療法により心不全症状が改善したCD36欠損症の一例

平野賢一, 長井直子, 橋本千佳子, 鈴木朗, 山口知是, 李銘, 原康洋, 柏木浩和, 冨山佳昭, 長坂博範

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 49th 297 (WEB ONLY)-297, Jun 25, 2017
GPIIb/IIIaの著明な発現低下を認めた後天性血小板無力症

芥田敬吾, 芥田敬吾, 柏木浩和, 湯尻俊昭, 西浦伸子, 西浦伸子, 森川陽一郎, 森川陽一郎, 加藤恒, 本田繁則 …

日本血栓止血学会誌, 28(2), 2017
The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Yoichiro Morikawa, Hisashi Kato, Keigo Akuta, Hirokazu Kashiwagi, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

BLOOD, 128(22), Dec, 2016
後天性フォン・ヴィレブランド症候群に併発した小脳出血の1例

尾崎友彦, 中村元, 横田千里, 角野喜則, 村上知義, 浅井克則, 西田武生, 倉重隆明, 柏木浩和, 吉峰俊樹

Neurosurgical Emergency, 20(3) 456-456, Jan, 2016
Efficacy and safety of anagrelide for essential thrombocythemia

柏木浩和

血液内科 = Hematology, 71(4) 523-528, Oct, 2015
Clinical significance of IPF% or RP% measurement in distinguishing primary immune thrombocytopenia from aplastic thrombocytopenic disorders

M. Sakuragi, S. Hayashi, M. Maruyama, O. Kabutomori, T. Kiyokawa, K. Nagamine, H. Kato, H. Kashiwagi, Y. Kanakura, Y. Tomiyama

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13 868-869, Jun, 2015
Severe bleeding tendency and impaired platelet function in a patient with CalDAG-GEFI deficiency

H. Kato, Y. Nakazawa, H. Kashiwagi, S. Tadokoro, Y. Morikawa, D. Morita, Y. Kurokawa, Y. Kanakura, Y. Tomiyama

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13 225-225, Jun, 2015
alpha IIb( R990W), a Constitutive Activating Mutation of Integrin alpha IIb beta 3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, Fumiaki Banno, Hisashi Kato, Youichiro Morikawa, Seiji Tadokoro, Koichi Kokame, Shigenori Honda, Toshiyuki Miyata …

BLOOD, 124(21), Dec, 2014
Demonstration of novel gain-of-function mutations of aIIb beta 3: association with macrothrombocytopenia and Glanzmann thrombasthenia-like phenotype

H. Kashiwagi, S. Kunishima, K. Kiyomizu, Y. Amano, H. Shimada, M. Morishita, Y. Kanakura, Y. Tomiyama

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11 455-455, Jul, 2013
Pathophysiology of primary ITP

冨山佳昭, 清水一亘, 柏木浩和

臨床免疫・アレルギー科, 59(6) 649-657, Jun, 2013
Epitope analysis of anti-αIIbβ3 autoantibodies in primary ITP：Recognition of highly restricted regions in the β-propeller domain by platelet-associated anti-αIIbβ3 autoantibodies

KIYOMIZU Kazunobu, KASHIWAGI Hirokazu, TOMIYAMA Yoshiaki

Nihon Kessen Shiketsu Gakkaishi, 24(4) 392-395, 2013

Books and Other Publications

血小板機能異常症の診断と治療: EBM血液疾患の治療2015-2016（金倉譲、木崎昌弘、鈴木律朗、神田善伸編）

柏木浩和 (Role: Contributor)

中外医学社, Nov, 2014
Clinical practice for thrombosis and hemostasis abnormality

Yoshiaki Tomiyama

Nakayama Publisher, Nov, 2014
ITPの病態解析: Annual Review血液2014（高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編)

柏木浩和 (Role: Contributor)

中外医学社, Jan, 2014
特発性血小板減少性紫斑病（ITP)；専門医のための薬物療法Q&A (小松則夫，片山直之，冨山佳昭編）

柏木浩和, 冨山佳昭 (Role: Contributor)

中外医学社, Oct, 2011
造血器腫瘍治療これは困ったぞ、どうしよう？第2版（押味和夫監修, 木崎昌弘, 松村到編

柏木浩和 (Role: Contributor)

中外医学社, Oct, 2010

Professional Memberships

Research Projects

新規実験システムを用いた血小板インテグリンシグナル制御機構の解析とその応用

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

柏木浩和, 加藤恒
プロテオミクスが同定するインテグリンαIIbβ3活性化機構から新規抗血小板療法へ

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

加藤恒, 柏木浩和, 中田継一
Molecular mechanism of platelet integrin activation and association with vascular lesion

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Hirokazu Kashiwagi
Analysis of regulatory mechanism for platelet integrin activation kinetics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Hisashi Kato
Characteriziation of regulatory molecules of platelet integrin function and their clinical application

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Tomiyama Yoshiaki
Analysis of platelet integrin signaling and association with vascular diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

KASHIWAGI Hirokazu
Identification and characterization of integrin inside-out signaling molecules employing a newly developed expeimental system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Tomiyama Yoshiaki
Analysis of regulatory mechanism of sustained integrin alphaIIbbeta3 activation.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kato Hisashi, Tomiyama Yoshiaki, Ichii Michiko
Arterial thrombosis and platelet integrin activation.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Kashiwagi Hirokazu, TOMIYAMA Yoshiaki
Analysis of regulatory molecule in platelets for thrombosis employing CMK cell system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

TOMIYAMA Yoshiaki, KASHIWAGI Hirokazu, TODOKORO Seiji
Analysis of positive or negative regulatory mechanism for thrombus formation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

TOMIYAMA Yoshiaki, ORITANI Kennji, KASHIWAGI Hirokazu, SHIRAGA Masamichi
Analysis of inhibitory mechanism and antithrombotic effects of a novel anti-platelet function molecule, semaphorin 3A

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

KASHIWAGI Hirokazu, TOMIYAMA Yoshiaki
Analysis of regulatory mechanism for α_<IIb>β_3 function by employing newly developed experimental system.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

TOMIYAMA Yoshiaki, ORITANI Kennji, KASHIWAGI Hirokazu
Analysis of anti-platelet and anti-thrombotic effects of a neuron guidance molecule,semaphorin 3A

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

KASHIWAGI Hirokazu, TOMIYAMA Yoshiaki

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