Hirofumi Kai

Last updated: Jul 31, 2019 at 15:25

Name	Hirofumi Kai
E-mail	hirokaigpo.kumamoto-u.ac.jp
Affiliation	Kumamoto University
Section	Faculty of Life Sciences

Published Papers

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A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH.

Ueda M, Okada M, Mizuguchi M, Kluve-Beckerman B, Kanenawa K, Isoguchi A, Misumi Y, Tasaki M, Ueda A, Kanai A, Sasaki R, Masuda T, Inoue Y, Nomura T, Shinriki S, Shuto T, Kai H, Yamashita T, Matsui H, Benson MD, Ando Y

The Journal of biological chemistry 294(29) 11259-11275 Jul 2019 [Refereed]

Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases.

Nakashima R, Kamei S, Nohara H, Fujikawa H, Maruta K, Kawakami T, Eto Y, Takahashi N, Suico MA, Takeo T, Nakagata N, Kai H, Shuto T

Journal of pharmacological sciences Mar 2019 [Refereed]

Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells.

Chaudhary N, Ueno-Shuto K, Ono T, Ohira Y, Watanabe K, Nasu A, Fujikawa H, Nakashima R, Takahashi N, Suico MA, Kai H, Shuto T

Biological & pharmaceutical bulletin 42(3) 489-495 Mar 2019 [Refereed]

Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation.

Kamei S, Maruta K, Fujikawa H, Nohara H, Ueno-Shuto K, Tasaki Y, Nakashima R, Kawakami T, Eto Y, Suico MA, Suzuki S, Gruenert DC, Li JD, Kai H, Shuto T

Biochemical and biophysical research communications 509(2) 521-528 Feb 2019 [Refereed]

Impact of hepatic HSP72 on insulin signaling.

Kitano S, Kondo T, Matsuyama R, Ono K, Goto R, Takaki Y, Hanatani S, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E

American journal of physiology. Endocrinology and metabolism 316(2) E305-E318 Feb 2019 [Refereed]

Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. var. cordiformis (Makino) Kitam.

Chaudhary N, Sasaki R, Shuto T, Watanabe M, Kawahara T, Suico MA, Yokoyama T, Mizuguchi M, Kai H, Devkota HP

Molecules (Basel, Switzerland) 24(3) Jan 2019 [Refereed]

Mild electrical stimulation with heat shock reduces inflammatory symptoms in the imiquimod-induced psoriasis mouse model.

Tsurekawa Y, Morita M, Suico MA, Moriuchi M, Nakano Y, Piruzyan M, Takada M, Fukami S, Shuto T, Kai H

Experimental dermatology 27(10) 1092-1097 Oct 2018 [Refereed]

Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants.

Elbashir SMI, Devkota HP, Wada M, Kishimoto N, Moriuchi M, Shuto T, Misumi S, Kai H, Watanabe T

BMC complementary and alternative medicine 18(1) 282 Oct 2018 [Refereed]

A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome.

Omachi K, Kamura M, Teramoto K, Kojima H, Yokota T, Kaseda S, Kuwazuru J, Fukuda R, Koyama K, Matsuyama S, Motomura K, Shuto T, Suico MA, Kai H

Cell chemical biology 25(5) 634-643.e4 May 2018 [Refereed]

Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family.

Kudo E, Taura M, Suico MA, Goto H, Kai H, Okada S

International journal of molecular medicine 41(4) 2366-2374 Apr 2018 [Refereed]

STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model.

Yokota T, Omachi K, Suico MA, Kamura M, Kojima H, Fukuda R, Motomura K, Teramoto K, Kaseda S, Kuwazuru J, Takeo T, Nakagata N, Shuto T, Kai H

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 33(2) 214-223 Feb 2018 [Refereed]

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.

Kamei S, Fujikawa H, Nohara H, Ueno-Shuto K, Maruta K, Nakashima R, Kawakami T, Matsumoto C, Sakaguchi Y, Ono T, Suico MA, Boucher RC, Gruenert DC, Takeo T, Nakagata N, Li JD, Kai H, Shuto T

EBioMedicine 27 304-316 Jan 2018 [Refereed]

Characterization of Non-amyloidogenic G101S Transthyretin.

Wakita Y, Sato T, Chosa K, Suico MA, Sasaki R, Kawano S, Hashimoto N, Teranishi Y, Imai Y, Morioka H, Shuto T, Kai H

Biological & pharmaceutical bulletin 41(4) 628-636 2018 [Refereed]

Taurine Inhibits TRPV-Dependent Activity to Overcome Oxidative Stress in Caenorhabditis elegans.

Moriuchi M, Nakano Y, Tsurekawa Y, Piruzyan M, Matsuyama S, Nohara H, Suico MA, Shuto T, Kai H

Biological & pharmaceutical bulletin 41(11) 1672-1677 2018 [Refereed]

6-Formylindolo[3,2-b]Carbazole Accelerates Skin Wound Healing via Activation of ERK, but Not Aryl Hydrocarbon Receptor.

Morino-Koga S, Uchi H, Mitoma C, Wu Z, Kiyomatsu M, Fuyuno Y, Nagae K, Yasumatsu M, Suico MA, Kai H, Furue M

The Journal of investigative dermatology 137(10) 2217-2226 Oct 2017 [Refereed]

Bromide supplementation exacerbated the renal dysfunction, injury and fibrosis in a mouse model of Alport syndrome.

Yokota T, Omachi K, Suico MA, Kojima H, Kamura M, Teramoto K, Kaseda S, Kuwazuru J, Shuto T, Kai H

PloS one 12(9) e0183959 Sep 2017 [Refereed]

STAT3 INHIBITION ATTENUATES THE PROGRESSIVE PHENOTYPES OF ALPORT SYNDROME MOUSE MODEL

Yokota Tsubasa, Omachi Kohei, Kamura Misato, Kojima Haruka, Teramoto Keisuke, Kaseda Shota, Kuwazuru Jun, Fukuda Ryosuke, Suico Mary Ann, Shuto Tsuyoshi, Kai Hirofumi

PEDIATRIC NEPHROLOGY 32(9) 1654 Sep 2017 [Refereed]

TARGETING THE TYPE IV COLLAGEN MISFOLDING IN HEREDITARY NEPHRITIS ALPORT SYNDROME

Omachi Kohei, Teramoto Keisuke, Kamura Misato, Kojima Haruka, Suico Mary Ann, Shuto Tsuyoshi, Kai Hirofumi

PEDIATRIC NEPHROLOGY 32(9) 1653 Sep 2017 [Refereed]

The Metabolic Roles of Heat Shock Protein 72 in Mice Model of Diabetes

Kondo Tatsuya, Kitano Sayaka, Goto Rieko, Ono Kaoru, Igata Motoyuki, Kawashima Junji, Motoshima Hiroyuki, Matsumura Takeshi, Kai Hirofumi, Araki Eiichi

DIABETES 66 A508 Jun 2017 [Refereed]

Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm.

Koga T, Shiraki N, Yano S, Suico MA, Morino-Koga S, Sato T, Shuto T, Kume S, Kai H

BMC biotechnology 17(1) 14 Feb 2017 [Refereed]

Long-term treatment with EGFR inhibitor erlotinib attenuates renal inflammatory cytokines but not nephropathy in Alport syndrome mouse model.

Omachi K, Miyakita R, Fukuda R, Kai Y, Suico MA, Yokota T, Kamura M, Shuto T, Kai H

Clinical and experimental nephrology 21(6) 952-960 Feb 2017 [Refereed]

Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases.

Shuto T, Kamei S, Nohara H, Fujikawa H, Tasaki Y, Sugahara T, Ono T, Matsumoto C, Sakaguchi Y, Maruta K, Nakashima R, Kawakami T, Suico MA, Kondo Y, Ishigami A, Takeo T, Tanaka KI, Watanabe H, Nakagata N, Uchimura K, Kitamura K, Li JD, Kai H

Scientific reports 6 39305 Dec 2016 [Refereed]

Roles and regulations of the ETS transcription factor ELF4/MEF.

Suico MA, Shuto T, Kai H

Journal of molecular cell biology 9(3) 168-177 Dec 2016 [Refereed]

Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.

Kondo T, Goto R, Ono K, Kitano S, Suico MA, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E

Scientific reports 6 35690 Oct 2016 [Refereed]

Activation of heat shock response improves glucose metabolism and inflammation in obese subjects with type 2 diabetes

Kondo Tatsuya, Goto Rieko, Ono Kaoru, Kitano Sayaka, Igata Motoyuki, Kawashima Junji, Motoshima Hiroyuki, Matsumura Takeshi, Kai Hirofumi, Araki Eiichi

DIABETES RESEARCH AND CLINICAL PRACTICE 120 S61 Oct 2016 [Refereed]

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.

Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC

Molecular therapy. Nucleic acids 5 e273 Jan 2016 [Refereed]

Podocyte p53 Limits the Severity of Experimental Alport Syndrome.

Fukuda R, Suico MA, Kai Y, Omachi K, Motomura K, Koga T, Komohara Y, Koyama K, Yokota T, Taura M, Shuto T, Kai H

Journal of the American Society of Nephrology : JASN 27(1) 144-157 Jan 2016 [Refereed]

The ETS Factor Myeloid Elf-1-Like Factor (MEF)/Elf4 Is Transcriptionally and Functionally Activated by Hypoxia.

Suico MA, Taura M, Kudo E, Gotoh K, Shuto T, Okada S, Kai H

Biological & pharmaceutical bulletin 39(4) 641-647 2016 [Refereed]

Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury.

Koga T, Suico MA, Shimasaki S, Watanabe E, Kai Y, Koyama K, Omachi K, Morino-Koga S, Sato T, Shuto T, Mori K, Hino S, Nakao M, Kai H

The Journal of biological chemistry 290(51) 30366-30374 Dec 2015 [Refereed]

Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione.

Yokoyama T, Takaki S, Chosa K, Sato T, Suico MA, Teranishi Y, Shuto T, Mizuguchi M, Kai H

Journal of pharmacological sciences 129(4) 240-243 Dec 2015 [Refereed]

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP.

Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H, Nishitoh H

Cell reports 13(5) 944-956 Nov 2015 [Refereed]

Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.

Susuki-Miyata S, Miyata M, Lee BC, Xu H, Kai H, Yan C, Li JD

Proceedings of the National Academy of Sciences of the United States of America 112(14) E1800-9 Apr 2015 [Refereed]

COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization.

Taura M, Kudo E, Kariya R, Goto H, Matsuda K, Hattori S, Vaeteewoottacharn K, McDonald F, Suico MA, Shuto T, Kai H, Okada S

Journal of virology 89(5) 2643-2658 Mar 2015 [Refereed]

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.

Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD

Nature communications 6 6062 Jan 2015 [Refereed]

Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.

Kondo T, Ono K, Kitano S, Matsuyama R, Goto R, Suico MA, Kawasaki S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E

EBioMedicine 1(1) 80-89 Nov 2014 [Refereed]

The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism.

Suico MA, Fukuda R, Miyakita R, Koyama K, Taura M, Shuto T, Kai H

The Journal of biological chemistry 289(38) 26143-26154 Sep 2014 [Refereed]

Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils.

Ueno-Shuto K, Kato K, Tasaki Y, Sato M, Sato K, Uchida Y, Sakai H, Ono T, Suico MA, Mitsutake K, Tokutomi N, Kai H, Shuto T

The Journal of biological chemistry 289(26) 18097-18109 Jun 2014 [Refereed]

Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter.

Suzuki S, Shuto T, Sato T, Kaneko M, Takada T, Suico MA, Cyr DM, Suzuki H, Kai H

Scientific reports 4 4258 Mar 2014 [Refereed]

HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-κB pathway.

Kariya R, Taura M, Suzu S, Kai H, Katano H, Okada S

Cancer letters 342(1) 52-59 Jan 2014 [Refereed]

Mild electrical stimulation increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway in C. elegans.

Matsuyama S, Moriuchi M, Suico MA, Yano S, Morino-Koga S, Shuto T, Yamanaka K, Kondo T, Araki E, Kai H

PloS one 9(12) e114690 2014 [Refereed]

Evaluation of three-dimensional cultured HepG2 cells in a nano culture plate system: an in vitro human model of acetaminophen hepatotoxicity.

Aritomi K, Ishitsuka Y, Tomishima Y, Shimizu D, Abe N, Shuto T, Irikura M, Kai H, Irie T

Journal of pharmacological sciences 124(2) 218-229 2014 [Refereed]

Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway.

Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S

Free radical biology & medicine 65 778-788 Dec 2013 [Refereed]

Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte.

Hiraoka N, Arai Y, Takahashi KA, Mazda O, Kishida T, Honjo K, Tsuchida S, Inoue H, Morino S, Suico MA, Kai H, Kubo T

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 31(6) 894-900 Jun 2013 [Refereed]

Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress.

Morino-Koga S, Yano S, Kondo T, Shimauchi Y, Matsuyama S, Okamoto Y, Suico MA, Koga T, Sato T, Shuto T, Arima H, Wada I, Araki E, Kai H

Journal of cellular physiology 228(2) 439-446 Feb 2013 [Refereed]

Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.

Komatsu K, Lee JY, Miyata M, Hyang Lim J, Jono H, Koga T, Xu H, Yan C, Kai H, Li JD

Nature communications 4 1684 2013 [Refereed]

α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.

Komori H, Watanabe H, Shuto T, Kodama A, Maeda H, Watanabe K, Kai H, Otagiri M, Maruyama T

The Journal of biological chemistry 287(36) 30688-30700 Aug 2012 [Refereed]

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

Sato T, Sako Y, Sho M, Momohara M, Suico MA, Shuto T, Nishitoh H, Okiyoneda T, Kokame K, Kaneko M, Taura M, Miyata M, Chosa K, Koga T, Morino-Koga S, Wada I, Kai H

Molecular cell 47(1) 99-110 Jul 2012 [Refereed]

Heat Treatment With Mild Electrical Stimulation Reduces Visceral Adiposity and Improves Insulin Resistance and Inflammatory Markers in Male Subjects With Type 2 Diabetes

Kondo Tatsuya, Matsuyama Rina, Miyagawa Katsutoshi, Goto Rieko, Kawashima Junji, Motoshima Hiroyuki, Kai Hirofumi, Araki Eiichi

DIABETES 61 A238-A239 Jun 2012 [Refereed]

Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.

Lee J, Komatsu K, Lee BC, Lim JH, Jono H, Xu H, Kai H, Zhang ZJ, Yan C, Li JD

The Journal of biological chemistry 287(27) 22799-22811 Jun 2012 [Refereed]

Hyperthermia with mild electrical stimulation protects pancreatic β-cells from cell stresses and apoptosis.

Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E

Diabetes 61(4) 838-847 Apr 2012 [Refereed]

Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells.

Taura M, Suico MA, Koyama K, Komatsu K, Miyakita R, Matsumoto C, Kudo E, Kariya R, Goto H, Kitajima S, Takahashi C, Shuto T, Nakao M, Okada S, Kai H

Molecular and cellular biology 32(8) 1581-1590 Apr 2012 [Refereed]

Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway.

Matsuno T, Kariya R, Yano S, Morino-Koga S, Taura M, Suico MA, Shimauchi Y, Matsuyama S, Okamoto Y, Shuto T, Kai H, Okada S

International journal of oncology 40(4) 1071-1078 Apr 2012 [Refereed]

Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome.

Koga T, Kai Y, Fukuda R, Morino-Koga S, Suico MA, Koyama K, Sato T, Shuto T, Kai H

PloS one 7(8) e43852 2012 [Refereed]

Synergism between interleukin (IL)-17 and Toll-like receptor 2 and 4 signals to induce IL-8 expression in cystic fibrosis airway epithelial cells.

Mizunoe S, Shuto T, Suzuki S, Matsumoto C, Watanabe K, Ueno-Shuto K, Suico MA, Onuki K, Gruenert DC, Kai H

Journal of pharmacological sciences 118(4) 512-520 2012 [Refereed]

Heat shock response regulates insulin sensitivity and glucose homeostasis: pathophysiological impact and therapeutic potential.

Kondo T, Koga S, Matsuyama R, Miyagawa K, Goto R, Kai H, Araki E

Current diabetes reviews 7(4) 264-269 Jul 2011 [Refereed]

Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.

Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T

Biochemical and biophysical research communications 408(1) 18-24 Apr 2011 [Refereed]

CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation.

Hashimoto Y, Shuto T, Mizunoe S, Tomita A, Koga T, Sato T, Takeya M, Suico MA, Niibori A, Sugahara T, Shimasaki S, Sugiyama T, Scholte B, Kai H

Laboratory investigation; a journal of technical methods and pathology 91(4) 509-518 Apr 2011 [Refereed]

Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1.

Sugiyama T, Shuto T, Suzuki S, Sato T, Koga T, Suico MA, Kusuhara H, Sugiyama Y, Cyr DM, Kai H

Biochemical and biophysical research communications 404(3) 853-858 Jan 2011 [Refereed]

MEF/ELF4 transactivation by E2F1 is inhibited by p53.

Taura M, Suico MA, Fukuda R, Koga T, Shuto T, Sato T, Morino-Koga S, Okada S, Kai H

Nucleic acids research 39(1) 76-88 Jan 2011 [Refereed]

Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH kinase (PI-3K) / Akt pathway.

Yano S, Morino-Koga S, Kondo T, Suico MA, Koga T, Shimauchi Y, Matsuyama S, Shuto T, Sato T, Araki E, Kai H

Journal of pharmacological sciences 115(1) 94-98 2011 [Refereed]

Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells.

Shimasaki S, Koga T, Shuto T, Suico MA, Sato T, Watanabe K, Morino-Koga S, Taura M, Okada S, Mori K, Kai H

Biochemical and biophysical research communications 402(2) 235-240 Nov 2010 [Refereed]

An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice.

Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E

American journal of physiology. Endocrinology and metabolism 299(5) E764-71 Nov 2010 [Refereed]

Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma.

Ota K, Fujimori H, Ueda M, Jono H, Shinriki S, Ota T, Sueyoshi T, Taura M, Taguma A, Kai H, Shinohara M, Ando Y

International journal of oncology 37(4) 797-804 Oct 2010 [Refereed]

Curcumin decreases toll-like receptor-2 gene expression and function in human monocytes and neutrophils.

Shuto T, Ono T, Ohira Y, Shimasaki S, Mizunoe S, Watanabe K, Suico MA, Koga T, Sato T, Morino S, Sato K, Kai H

Biochemical and biophysical research communications 398(4) 647-652 Aug 2010 [Refereed]

The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site.

Miyata M, Sato T, Kugimiya M, Sho M, Nakamura T, Ikemizu S, Chirifu M, Mizuguchi M, Nabeshima Y, Suwa Y, Morioka H, Arimori T, Suico MA, Shuto T, Sako Y, Momohara M, Koga T, Morino-Koga S, Yamagata Y, Kai H

Biochemistry 49(29) 6104-6114 Jul 2010 [Refereed]

TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis.

Taura M, Fukuda R, Suico MA, Eguma A, Koga T, Shuto T, Sato T, Morino-Koga S, Kai H

Cancer science 101(7) 1610-1617 Jul 2010 [Refereed]

Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.

Kondo T, Sasaki K, Adachi H, Nakayama Y, Hatemura M, Matsuyama R, Tsuruzoe K, Furukawa N, Motoshima H, Morino Koga S, Yamashita Y, Miyamura N, Kai H, Araki E

Obesity research & clinical practice 4(2) e83-e162 Apr 2010 [Refereed]

The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.

Yoshida H, Takamura N, Shuto T, Ogata K, Tokunaga J, Kawai K, Kai H

Biochemical and biophysical research communications 394(3) 728-732 Apr 2010 [Refereed]

MUC1 expression by human airway epithelial cells mediates Pseudomonas aeruginosa adhesion.

Kato K, Lillehoj EP, Kai H, Kim KC

Frontiers in bioscience (Elite edition) 2 68-77 Jan 2010 [Refereed]

Ephedrae Herba, a Component of Japanese Herbal Medicine Mao-to, Efficiently Activates the Replication of Latent Human Immunodeficiency Virus Type 1 (HIV-1) in a Monocytic Cell Line

Murakami Toru, Harada Hideki, Suico Mary Ann, Shuto Tsuyoshi, Suzu Shinya, Kai Hirofumi, Okada Seiji

BIOLOGICAL & PHARMACEUTICAL BULLETIN 31(12) 2334-2337 Dec 2008 [Refereed]

p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines.

Taura M, Eguma A, Suico MA, Shuto T, Koga T, Komatsu K, Komune T, Sato T, Saya H, Li JD, Kai H

Molecular and cellular biology 28(21) 6557-6567 Nov 2008 [Refereed]

Mild Electrical Stimulation Increases Ubiquitinated Proteins and Hsp72 in A549 Cells via Attenuation of Proteasomal Degradation

Morino Saori, Suico Mary Ann, Kondo Tatsuya, Sekimoto Erika, Yano Shuichiro, Matsuda Tomoko, Matsuno Takashi, Shuto Tsuyoshi, Araki Eiichi, Kai Hirofumi

JOURNAL OF PHARMACOLOGICAL SCIENCES 108(2) 222-226 Oct 2008 [Refereed]

Role of conformational change in the C-terminus of beta2-microglobulin in dialysis-related amyloidosis.

Kim J, Motomiya Y, Ueda M, Nakamura M, Misumi Y, Saito S, Ikemizu S, Misumi S, Ota K, Shinriki S, Kai H, Ando Y

Annals of clinical biochemistry 45(Pt 5) 489-495 Sep 2008 [Refereed]

Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DeltaF508 CFTR.

Okiyoneda T, Niibori A, Harada K, Kohno T, Michalak M, Duszyk M, Wada I, Ikawa M, Shuto T, Suico MA, Kai H

Biochimica et biophysica acta 1783(9) 1585-1594 Sep 2008 [Refereed]

IFN-gamma down-regulates Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo.

Oba M, Yano S, Shuto T, Suico MA, Eguma A, Kai H

International journal of oncology 32(6) 1317-1324 Jun 2008 [Refereed]

Multi-elemental analysis of serum and amyloid fibrils in familial amyloid polyneuropathy patients.

Susuki S, Ando Y, Sato T, Nishiyama M, Miyata M, Suico MA, Shuto T, Kai H

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 15(2) 108-116 Jun 2008 [Refereed]

Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling.

Koga T, Lim JH, Jono H, Ha UH, Xu H, Ishinaga H, Morino S, Xu X, Yan C, Kai H, Li JD

The Journal of biological chemistry 283(18) 12546-12554 May 2008 [Refereed]

DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription.

Furuta T, Shuto T, Shimasaki S, Ohira Y, Suico MA, Gruenert DC, Kai H

BMC molecular biology 9 39 Apr 2008 [Refereed]

Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA.

Suwa Y, Nakamura T, Toma S, Ikemizu S, Kai H, Yamagata Y

Acta crystallographica. Section F, Structural biology and crystallization communications 64(Pt 3) 171-174 Mar 2008 [Refereed]

MUC1 mucin is a negative regulator of toll-like receptor signaling.

Ueno K, Koga T, Kato K, Golenbock DT, Gendler SJ, Kai H, Kim KC

American journal of respiratory cell and molecular biology 38(3) 263-268 Mar 2008 [Refereed]

Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes.

Iwakiri T, Okumura M, Matsunaga N, Ichihara E, Shiotsuki S, Nagata M, Kumagai Y, Kai H, Arimori K

European journal of pharmacology 580(1-2) 19-26 Feb 2008 [Refereed]

Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro.

Hidaka M, Nagata M, Kawano Y, Sekiya H, Kai H, Yamasaki K, Okumura M, Arimori K

Bioscience, biotechnology, and biochemistry 72(2) 406-411 Feb 2008 [Refereed]

Phosphatidic acid metabolism regulates the intracellular trafficking and retrotranslocation of CFTR.

Hashimoto Y, Okiyoneda T, Harada K, Ueno K, Sugahara T, Yamashita A, Shuto T, Suico MA, Kai H

Biochimica et biophysica acta 1783(1) 153-162 Jan 2008 [Refereed]

Hsp72 improves insulin resistance in type 2 diabetes mouse models

Morino Saori, Kondo Tatsuya, Sasaki Kazunari, Adachi Hironori, Sekimotol Erika, Yano Shuichiro, Matsuda Tomoko, Suico MaryAnn, Shuto Tsuvoshi, Araki Eiichi, Kai Hirofumi

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 60P 2008 [Refereed]

Heat shock suppresses human NK cell cytotoxicity via regulation of perforin.

Harada H, Murakami T, Tea SS, Takeuchi A, Koga T, Okada S, Suico MA, Shuto T, Kai H

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 23(8) 657-665 Dec 2007 [Refereed]

Increased responsiveness to TLR2 and TLR4 ligands during dimethylsulfoxide-induced neutrophil-like differentiation of HL-60 myeloid leukemia cells.

Shuto T, Furuta T, Cheung J, Gruenert DC, Ohira Y, Shimasaki S, Suico MA, Sato K, Kai H

Leukemia research 31(12) 1721-1728 Dec 2007 [Refereed]

Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans.

Chirifu M, Hayashi C, Nakamura T, Toma S, Shuto T, Kai H, Yamagata Y, Davis SJ, Ikemizu S

Nature immunology 8(9) 1001-1007 Sep 2007 [Refereed]

Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signaling.

Kato K, Lu W, Kai H, Kim KC

American journal of physiology. Lung cellular and molecular physiology 293(3) L686-92 Sep 2007 [Refereed]

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.

Huang Y, Mikami F, Jono H, Zhang W, Weng X, Koga T, Xu H, Yan C, Kai H, Li JD

Biochemical and biophysical research communications 359(3) 691-696 Aug 2007 [Refereed]

Crystal structure of IL-15/IL-15R alpha complex

Chirifu Mami, Hayashi Chiharu, Nakamura Teruya, Toma Sachiko, Shuto Tsuyoshi, Kai Hirofumi, Yamagata Yuriko, Davis Simon J., Ikemizu Shinji

CYTOKINE 39(1) 7 Jul 2007 [Refereed]

The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLD.

Sakai A, Koga T, Lim JH, Jono H, Harada K, Szymanski E, Xu H, Kai H, Li JD

The FEBS journal 274(14) 3655-3668 Jul 2007 [Refereed]

Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell.

Sato T, Susuki S, Suico MA, Miyata M, Ando Y, Mizuguchi M, Takeuchi M, Dobashi M, Shuto T, Kai H

The EMBO journal 26(10) 2501-2512 May 2007 [Refereed]

Curcumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticulin.

Harada K, Okiyoneda T, Hashimoto Y, Oyokawa K, Nakamura K, Suico MA, Shuto T, Kai H

Biochemical and biophysical research communications 353(2) 351-356 Feb 2007 [Refereed]

HGF increases the uptake of estradiol 17 beta -D-glucuronide through upregulation of Oatp1 protein level in primary cultured rat hepatocytes

Iwakiri Tomomi, Okumura Manabu, Ichihara Emi, Shiotsuki Satoshi, Nagata Masashi, Kumagai Yuki, Kai Hirofumi, Arimori Kazuhiko

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 70P 2007 [Refereed]

Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator.

Okiyoneda T, Niibori A, Harada K, Kohno T, Hashimoto Y, Kusuhara H, Takada T, Shuto T, Suico MA, Sugiyama Y, Kai H

Biochimica et biophysica acta 1763(10) 1017-1023 Oct 2006 [Refereed]

SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor.

Suico MA, Nakamura H, Lu Z, Saitoh H, Shuto T, Nakao M, Kai H

Biochemical and biophysical research communications 348(3) 880-888 Sep 2006 [Refereed]

Calreticulin facilitates the cell surface expression of ABCG5/G8.

Okiyoneda T, Kono T, Niibori A, Harada K, Kusuhara H, Takada T, Shuto T, Suico MA, Sugiyama Y, Kai H

Biochemical and biophysical research communications 347(1) 67-75 Aug 2006 [Refereed]

The transforming growth factor-beta-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation with NF-kappaB and MAPK phosphatase 1-dependent negative cross-talk with p38 MA

Mikami F, Lim JH, Ishinaga H, Ha UH, Gu H, Koga T, Jono H, Kai H, Li JD

The Journal of biological chemistry 281(31) 22397-22408 Aug 2006 [Refereed]

Calreticulin negatively regulates the cell surface expression of cystic fibrosis transmembrane conductance regulator.

Harada K, Okiyoneda T, Hashimoto Y, Ueno K, Nakamura K, Yamahira K, Sugahara T, Shuto T, Wada I, Suico MA, Kai H

The Journal of biological chemistry 281(18) 12841-12848 May 2006 [Refereed]

Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells.

Shuto T, Furuta T, Oba M, Xu H, Li JD, Cheung J, Gruenert DC, Uehara A, Suico MA, Okiyoneda T, Kai H

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20(6) 782-784 Apr 2006 [Refereed]

Misc

Plain Text

Cellular stress response pathways and diabetes mellitus

Eiichi Araki, Tatsuya Kondo, Hirofumi Kai

Diabetology International 6 239-242 Dec 2015