Hiroki Takeda

Profile Information

Affiliation: 助教, 大学院生命科学研究部（医）, 熊本大学

J-GLOBAL ID: 201901001939199073
researchmap Member ID: B000380675

Research Areas

Life sciences / Otorhinolaryngology /

Papers

Nestin-expressing cells are mitotically active in the mammalian inner ear.

Olivia Kalmanson, Hiroki Takeda, Sean R Anderson, Anna Dondzillo, Samuel Gubbels

Hearing research, 443 108962-108962, Mar 1, 2024 Peer-reviewed
Significance of Continuous Low-Dose Lenvatinib for the Treating of the Patients with Unresectable Thyroid Carcinoma.

Daizo Murakami, Kohei Nishimoto, Soshi Takao, Satoru Miyamaru, Tomoka Kadowaki, Haruki Saito, Hiroki Takeda, Momoko Ise, Koichi Suyama, Yorihisa Orita

Acta medica Okayama, 78(1) 63-70, Feb, 2024
Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment

Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata …

Clinical and Translational Medicine, 13(8) e1350, 2023 Peer-reviewed
Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann–Pick disease type C without hearing loss

Yusei Yamada, Toru Miwa, Masaki Nakashima, Aina Shirakawa, Akira Ishii, Nanami Namba, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama …

Biomedicine & Pharmacotherapy, 155 113698-113698, Nov, 2022 Peer-reviewed
当科における軟骨伝導補聴器装用症例

伊勢桃子, 竹田大樹, 折田頼尚

日本耳科学会総会・学術講演会抄録集, 31回 400-400, Oct, 2021
Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti.

Hiroki Takeda, Anna Dondzillo, Jessica A Randall, Samuel P Gubbels

Stem cell research & therapy, 12(1) 352-352, Jun 19, 2021 Peer-reviewedLead author
Optimal management of the unilateral recurrent laryngeal nerve involvement in patients with thyroid cancer

Satoru Miyamaru, Daizo Murakami, Kohei Nishimoto, Narihiro Kodama, Joji Tashiro, Yusuke Miyamoto, Haruki Saito, Hiroki Takeda, Momoko Ise, Yorihisa Orita

Cancers, 13(9), May 1, 2021 Peer-reviewed
Application of artificial intelligence using a convolutional neural network for detecting cholesteatoma in endoscopic enhanced images.

Toru Miwa, Ryosei Minoda, Tomoya Yamaguchi, Shin-Ichiro Kita, Kazuto Osaka, Hiroki Takeda, Shin-Ichi Kanemaru, Koichi Omori

Auris, nasus, larynx, Apr 3, 2021
Differential mode of cholesterol inclusion with 2-hydroxypropyl-cyclodextrins impacts safety margin in treating Niemann-Pick disease type C.

Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Shuichi Nakahara, Asami Nishiyama, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima …

British journal of pharmacology, 178(13) 2727-2746, Mar 29, 2021 Peer-reviewed
Sex difference in the efferent inner hair cell synapses of the aging murine cochlea.

Anna Dondzillo, Hiroki Takeda, Samuel P Gubbels

Hearing research, 404 108215-108215, Feb 21, 2021 Peer-reviewed
Cholesteatoma Imaging Using a Digital Image Enhancement System During Endoscopic Ear Surgery.

Toru Miwa, Hiroki Takeda, Ryosei Minoda

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 42(2) e244, Feb 1, 2021 Peer-reviewed
外耳道耳垢腺多形腺腫の一例

寺田夕希, 竹田大樹, 伊勢桃子, 折田頼尚

日本耳科学会総会・学術講演会抄録集, 30回 292-292, Nov, 2020
新生児マウス内耳に対するヒト幹細胞移植

竹田大樹, 寺田友希, 伊勢桃子, 折田頼尚

日本耳科学会総会・学術講演会抄録集, 30回 317-317, Nov, 2020
当科における先天性真珠腫の臨床検討

伊勢桃子, 熊井良彦, 竹田大樹, 折田頼尚

日本耳科学会総会・学術講演会抄録集, 30回 300-300, Nov, 2020
Efficient In Utero Gene Transfer to the Mammalian Inner Ears by the Synthetic Adeno-Associated Viral Vector Anc80L65

Chin-Ju Hu, Ying-Chang Lu, Yi-Hsiu Tsai, Haw-Yuan Cheng, Hiroki Takeda, Chun-Ying Huang, Ru Xiao, Chuan-Jen Hsu, Jin-Wu Tsai, Luk H. Vandenberghe …

Molecular Therapy - Methods & Clinical Development, 18 493-500, Sep, 2020 Peer-reviewed
Prenatal electroporation-mediated gene transfer restores Slc26a4 knock-out mouse hearing and vestibular function.

Hiroki Takeda, Toru Miwa, Min Young Kim, Byung Yoon Choi, Yorihisa Orita, Ryosei Minoda

Scientific reports, 9(1) 17979-17979, Nov 29, 2019 Peer-reviewed
顔面神経麻痺、めまい、外耳道皮膚浸潤病変を呈した成人T細胞性白血病の1例

廣田薫瑠子, 熊井良彦, 竹田大樹, 伊勢桃子, 折田頼尚

日本耳科学会総会・学術講演会抄録集, 29回 211-211, Oct, 2019
顔面神経麻痺、めまい、外耳道皮膚浸潤病変を呈した成人T細胞性白血病の1例

廣田薫瑠子, 熊井良彦, 竹田大樹, 伊勢桃子, 折田頼尚

日本耳科学会総会・学術講演会抄録集, 29回 211-211, Oct, 2019
Engraftment of Human Pluripotent Stem Cell-derived Progenitors in the Inner Ear of Prenatal Mice.

Hiroki Takeda, Makoto Hosoya, Masato Fujioka, Chika Saegusa, Tsubasa Saeki, Toru Miwa, Hideyuki Okano, Ryosei Minoda

Scientific reports, 8(1) 1941-1941, Jan 31, 2018 Peer-reviewed
Challenges in Cell-Based Therapies for the Treatment of Hearing Loss.

Hiroki Takeda, Anna Dondzillo, Jessica A. Randall, Samuel P. Gubbels

Trends in Neurosciences, 41 823-837, 2018 Peer-reviewed

Misc.

Niemann-Pick病C型治療における2-hydroxypropyl-β-cyclodextrin脳室内投与療法の有効性および聴覚毒性評価を企図した逆向き橋渡し研究

白川愛奈, 山田侑世, 近藤悠希, 西山麻美, 河田達哉, 三輪徹, 竹田大樹, 折田頼尚, 竹尾透, 中潟直己 …

日本薬理学雑誌, 157(Supplement), 2022
Niemann-Pick病C型治療における2-hydroxypropyl-β-cyclodextrinの聴覚障害回避を目的とした至適投与条件の検討

白川愛奈, 山田侑世, 山田侑世, 近藤悠希, 西山麻美, 三輪徹, 竹田大樹, 折田頼尚, 竹尾透, 中潟直己 …

医療薬学フォーラム講演要旨集, 29th, 2021
めまい疾患のモデル動物遺伝子医療・再生医療への扉胎生期内耳をターゲットとした遺伝性内耳疾患に対する治療法開発の基礎研究

三輪徹, 竹田大樹, Choi Byung Yoon, 蓑田涼生

Equilibrium Research, 75(5) 348-348, Oct, 2016
NEPA21(NEPAGENE社)を用いた耳胞への遺伝子導入の条件検討

三輪徹, 竹田大樹, 山田卓生, 伊勢桃子, 蓑田涼生, 湯本英二

Otol Jpn, 25(4) 661-661, Sep 8, 2015
正円窓経由による内耳への蛋白質導入

竹田大樹, 蓑田涼生, 山田卓生, 伊勢桃子, 湯本英二

Otol Jpn, 24(4) 535-535, Sep 16, 2014
Arginine‐Rich Cell‐Penetrating Peptides(CPPs)を用いた蝸牛への蛋白質導入

竹田大樹, 蓑田涼生, 山田卓生, 伊勢桃子, 湯本英二

日本耳鼻咽喉科学会会報, 117(4) 508-508, Apr 20, 2014
Arginine‐Rich Cell‐Penetrating Peptides(CPPs)を用いた蝸牛への蛋白質導入

竹田大樹, 蓑田涼生, 山田卓生, 伊勢桃子, 湯本英二

Otol Jpn, 23(4) 508, Oct 25, 2013
早期声門癌に対するレーザー治療の検討

竹田大樹, 村上大造, 湯本英二

頭けい部癌, 39(2) 195, May 21, 2013

Research Projects

Cell transplantation for regeneration of the inner ear hair cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2024

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