2020年6月
Study of charged particle activation analysis (II): Determination of boron concentration in human blood samples
Applied Radiation and Isotopes
- 巻
- 164
- 号
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.apradiso.2020.109106
- 出版者・発行元
- Elsevier
Boron Neutron Capture Therapy (BNCT) is a radiotherapy for the treatment of intractable cancer. In BNCT precise determination of B concentration in whole blood sample before neutron irradiation of the patient, as well as accurate neutron dosimetry, is crucial for control of the neutron irradiation time. For this purpose ICP-AES and neutron induced prompt γ-ray analysis are generally used. In Ibaraki Neutron Medical Research Center (iNMRC), an intense proton beam will be accelerated up to 8 MeV, which can also be used for Charged Particle Activation Analysis (CPAA). Thus, in this study, we apply the CPAA utilizing the proton beam to non-destructive and accurate determination of B concentration in whole blood sample. A CPAA experiment is performed by utilizing an 8 MeV proton beam from the tandem accelerator of Nuclear Science Research Institute in Japan Atomic Energy Agency. The 478 keV γ-ray of Be produced by the B(p, α)Be reaction is used to quantify the B in human blood. The 478 keV γ-ray intensity is normalized by the intensities of the 847 keV and 1238 keV γ-rays of Co originating from Fe in blood. The normalization methods were found to be linear in the range of 3.27 μg B/g to 322 μg B/g with correlation coefficients of better than 0.9999.
- ID情報
-
- DOI : 10.1016/j.apradiso.2020.109106
- ISSN : 1872-9800